Abstract
The interactions of anesthetic and adjuvant drugs with neuromuscular blocking agents (muscle relaxants; m.r.)* has great clinical significance. Because of this, the understanding of the biochemical and pharmacological basis of these interactions is essential for the safe conduet of anesthesia. Limitations of space do not allow the in-depth coverage of this important topic. For this reason the ensuing discussion will be primarily concerned with those aspects of the interactions of m.r. and anesthetic and adjuvant drugs which have practical clinical importance. The species differences in the interaction of different types of m.r. with each other and with anesthetic and adjuvant drugs will only be considered when this become necessary for the clarification of conflicting clinical-pharmacological observations.
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References
ADAMSON, R.H., MARSHALL, F.N., LONG, J.P.: Neuromuscular blocking properties of various polypeptide antibiotics. Proc.Soc.Exp.Biol. Med. 105, 494 (1960).
BAART, N., SHANOR, S.P., VAN HEES, G. R., ERDOS,E. G., FOLDES, F. F.: Inhibitory effect of local anesthetics and their halogenated analogs on human plasma and red cell Cholinesterase. Fed.Proc. 15, 395 (1956).
BARAKA, A.: Irreversible tubocurarine neuromuscular block in the human. Br.J.Anaesth. 39, 891 (1967).
BENZ, H.E., LUNN, J.N., FOLDES,F.F.: “Recurarization” by intraperitoneal antibiotics. Br.Med.J. 2, 241 (1961).
Boere, L.A.: Recurarization nach Chinidinsulfat. Anaesthesist 13, 368 (1964).
BRAZIL, O.V., CORRADO, A.P.: The curariform action of streptomycin. J.Pharmacol.Exp.Ther. 120, 452 (1957).
CASTILLO, J.C., BEER, E.J., de: The neuromuscular blocking action of succinylcholine (diacetylcholine). J.Pharmavol.Exp.Ther. 99, 458 (1950).
CORRADO, A.P.: Respiratory depression due to antibiotics: calcium in treatment. Anesth.Anaig. 42, 1 (1963).
CRAIG, H.J.L.: The protective effect if thiopentone against muscular pains and stiffness which follows the use of suxamethonium. Br.J.Anaesth. 36, 612 (1964).
DOENICKE, A., KRUMEY, I., KUGLER, J., KLEMPA, J.: Experimental studies of the breakdown of epontol: determination of propanidid in human serum. Br.J.Anaesth. 40, 415 (1968).
DRETCHEN, K., GHONEIM, M.M., LONG, J.P.: The interaction of diazepam with myoneural blocking agents. Anesthesiology 34, 463 (1971).
ECKENHOFF, J.E.: The use of controlled hypotension for surgical procedures. Surg.Clin.North Am. 35, 1579 (1955).
ELLIS, C.H., WNUCK, A.L., DEBEER, E.J., FOLDES,F.F.: Modifying actions of procaine on myoneural blocking actions of succinylcholine, decamethonium and d-tubocurarine in dogs and cats. Am.J.Physiol. 174, 277 (1953).
ELLIS, R.F.: The neuromuscular interaction of propanidid with suxamethonium and tubocurarine. Br.J.Anaesth. 40, 818 (1968).
FELDMAN, S.A., CRAWLEY, B.E.: Interaction of diazepam with muscle relaxant drugs. Br.Med.J. 2, 336 (1970).
FELDMAN, S.A., CRAWLEY, B.E.: Diazepam and muscle relaxants. Br. Med.J. 1, 691 (1970).
FOLDES, F.F.: Muscle Relaxants In Anesthesiology. Ch.C.Thomas, Springfield, III. 1957, pp.40-44.
FOLDES,F.F.: Factors which alter the effects of muscle relaxants. Anesthesiology 20, 464 (1959).
FOLDES, F.F.: The Choice and mode of administration of relaxants. In Clinical Anesthesia: Muscle Relaxants. F.F. Foldes (Ed.). F.A. Davis Co. Philadelphia, Pa. 1966. 2, 1.
FOLDES, F.F.: Gegenwärtige Auffassungen über den Wirkungsmechanismus der Neuromuskulären Blocker. Acta Anaesthesiol. Scand. (Suppl. XXV) p. 207–218, 1966.
FOLDES, F.F.: Presynaptic aspects of neuromuscular transmission and block. Anaesthesist 20, 6 (1971).
FOLDES, F.F., AMBRUS, J.L., BACK, N., BARDOS, T.J., FOLDES, V.M.: Relationship between the antiCholinesterase activity and side effect liability of AB-132 in man. Fed.Proc. 21, 335 (1962).
FOLDES, F.F., ERDOS, E.G., ZSIGMOND, E.K., ZWARTZ, J.A.: Reactivation of neostigmine inhibited human plasma Cholinesterase. J.Pharmacol. Exper.Ther. 129, 394 (1960).
FOLDES, F.F., FOLDES, V.M., McNALL,P.G.: The use of echothiophate in myasthenia gravis. Clin.Pharmacol.Ther. 7, 620 (1966).
FOLDES, F.F., FOLDES, V.M., SMITH, J.C., ZSIGMOND, E.K.: The relation between plasma Cholinesterase and prolonged apnea caused by succinylcholine. Anes thesiology 24, 208 (1963).
FOLDES, F.F., HILLMER, N.R., MOLLOY, R.E., MONTE, A.P.: Potentiation of the neuromuscular effect of succinylcholine by hexafluorenium. Anesthesiology 21, 50 (1960).
FOLDES, F.F., KLONYMUS, D.H., MAISEL, W., SCIAMMAS,F., PAN,T.: Studies of pancuronium in conscious and anesthetized man. Anesthesiology 35, 496 (1971).
FOLDES, F.F., LUNN, J.N., BENZ, H.G.: Respiratory depression from drug combinations. J.A.M.A. 183, 672 (1963).
Foldes, F.F., Machaj, T.S., Hunt, R.D., McNall,P.G., Carberry,P.C: Synthetic muscle relaxants in anesthesia. J.A.M.A. 150, 1559 (1952).
FOLDES, F.F., RENDELL-BAKER, L., BURCH, J.H.: Causes and prevention of prolonged apnea with succinylcholine. Anesth.Anaig. 35 609 (1956).
FOLDES, F.F., RHODES, Jr.D.H.: The role of plasma Cholinesterase in anesthesiology. Anesth.Anaig. 32, 305 (1953).
FOLDES, F.F., SOKOLL, M., WOLFSON,B.: Combined use of halothane and neuromuscular blocking agents for the production of surgical relaxation. Anesth.Anaig. 40, 629 (1961).
FOLDES, F.F., WNUCK, A.L., HODGES, R.J.H., THESLEFF,S., DE BEER,E.J.: The mode of action of depolarizing relaxants. Anesth.Anaig. 36, 23 (1957).
FOLDES, F.F., WOLFSON, B., TORRES-KAY, M., MONTE,A.: The neuromuscular activity of hexamethylene-1,6-bis-carabaminoylcholine bromide (Imbretil) in man. Anesthesiology 20, 767 (1959).
FURUKAWA, T.: Properties of procaine end.plate potential. Jap.J. Physiol. 7, 199 (1957).
HANGUAT, M.: Reciprocal antagonistic effects of curaremimetic and acetylcholinomimetic drugs. In Proceedings of the World Congress of Anesthesiologists. Scheveningen, The Nehterlands, Sept.5-10, 1955, pp. 287–293.
HARRAH, M.D., WAY, W.L., KATZUNG, B.G.: The interaction of d-tubocurarine with antiarrhythmic drugs. Anesthesiology 33, 406 (1970).
HARVEY, A.M.: Actions of procaine on neuromuscular transmission. Bull.Johns Hopkins Hosp. 65, 223 (1939).
HUNTER, A.R.: Diazepam as a muscle relaxant during general anesthesia. Br.J.Anaesth. 39, 633 (1967).
JENDEN, D.J., KAMIJO, K., TAYLOR, D.B.: Action of decamethonium on isolated rabbit lumbrical muscle. J.Pharmacol.Exp.Ther. 111, 229 (1954).
JONES, W.P.G.: Calcium treatment for ineffective respiration resulting from administration of neomycin. J.A.M.A. 170, 943 (1959).
JÖRGENSEN, H.: Premedicinering med diazepam. Nord.Med. 72 1395 (1964).
KALOW, W.: Familial incidence of low pseudoCholinesterase level. Lancet 2, 576 (1956).
KATZ, B., THESLEFF, S.: A study of the desensitization produced by acetylcholine at the motor end-plate. J.Physiol. 138, 63 (1957).
KATZ, R.L.: Neuromuscular effects of diethyl ether and its interaction with succinylcholine and d-tubocurarine. Anesthesiology 27, 52 (1966).
KATZ, R.L.: Modification of the action of paneuronium by succinylcholine and halothane. Anesthesiology 35, 602 (1971).
KATZ, R.L., GISSEN, A.J.: Neuromuscular and electromyographic effects of halothane and its interaction with d-tubocurarine in man. Anesthesiology 28, 564 (1967).
KATZ, R.L., KATZ, G.J.: Complications associated with the use of muscle relaxants. In Clinical Anesthesia: Muscle Relaxants. F.F. FOLDES (Ed.) F.A. Davis Co. Philadelphia, Pa. 1966, 2, 121.
KLUPP,H., KRAUPP,O.: Über die Freisetzung von Kalium aus den Muskelrelaxantien. Arch.Pharm. 98, 340 (1954).
KOELLE, G.B.: Neuromuscular blocking agents. In the Pharmacological Basis of Therapeutics, 3rd ed., L.S. GOODMAN and A. GILMAN (Eds.) Macmillan Co. New York 1965, pp. 596–613.
LEBOWITZ, M.H., BLITT, C.D., WALTS,L.F.: Depression of twitch response to Stimulation of the ulnar nerve during ethrane anesthesia in man. Anesthesiology 33, 52 (1970).
LEOPOLD, J.H., KRISHNA, N.: Local use of antiCholinesterase agents in ocular therapy. In Cholinesterase and AntiCholinesterase Agents (Koelle,G.B. ed) Handb.exp.Pharmak. Suppl. 15, pp. 374–427. Berlin: Springer-Verlag 1963.
MAYRHOFER,O.: Die Nebenwirkungen des Succinylcholins und ihre Verhütung. In Proceedings of the International Symposium on Curare and Curare-like Agents. Venice, Italy, Sept. 12-15, 1958, pp. 376-379.
MILLER, R.D., EGER, E.I., WAY, W.L.: Comparative neuromuscular effects of forane and halothane alone in combination with d-tubocurarine in man. Anesthesiology 35, 38 (1971).
MULLETT, R.D., KEATS, A.S.: Apnea and respiratory insufficiency after intraperitoneal administration of kanamycin. Surgery 49, 530 (1961).
NGAI, S.H., HANKS, E.C., FAHRIE, S.E.: Effects of anesthetics on neuromuscular transmission and somatic reflexes. Anesthesiology 26, 162 (1965).
PANTUCK, E.J.: Ecothiopate iodide eye drops and prolonged response to suxamethonium. Br. J.Anaesth. 38, 406 (1966).
PARADA, J.F., MOLINA, F.J.: Intravenous procaine anesthesia, an Argentine technique. In Proc.First European Cong. Anaesth. Vienna, Austria, 2, 152 (1962).
PATON, W.D.M., ZAIMIS, E.J.: Pharmacological actions of polymethylenebistri-methyl-ammonium salte. Br.J.Pharmacol. 4, 381 (1949).
PIDGEN, J.E.: Respiratory arrest thought to be due to intraperitoneal neomycin. Surgery 40, 571 (1956).
Pittinger, C.B.: Anatagonists of muscle relaxants. In Clinical Anesthesia Muscle Relaxants. F.F. FOLDES (Ed.) F.A. Davis Co., Philadelphia, Pa., 1966, 2, 95.
PITTINGER, C.B., ERYASA, Y. and ADAMSON,R.: Antibiotic-induced paralysis. Anesth.Anaig. 49, 487 (1970).
PITTINGER, C.B., LONG, J.P. and MILLER, J.R.: The neuromuscular blocking action of neomycin. Anesth.Anaig. 37, 276 (1958).
Riker, W.F.Jr., WESCOE,W.C.: Studies on the interrelatioship of certain cholinergic Compounds. J.Pharmacol.Exp.Ther. 100, 454 (1950).
SABAWALA, P.B. and DILLON, J.B.: The action of some antibiotics on the human intercostal nerve-muscle complex. Anesthesiology 20, 659 (1959).
SALGADO, A.S.: Potentiation of succinylcholine by procaine. Anesthesiology 22, 897 (1961).
SCHMIDT, J.L., VICK, N.A. and SADOVE, M.S.: The effect of quinidine on the action of muscle relaxants. J.A.M.A. 183, 669 (1963).
SHANES, A.M.: Electrochemical aspects of physiological and pharmacological action in excitable cells: resting cell and its alteration by extrinsic factors. PharmacolRev. 10, 59 (1958).
STOVNER, J., ENDRESEN, R.: Diazepam in intravenous anesthesia. Lancet 2, 1298 (1965).
STOVNER, J., ENDRESEN, R.: Intravenous anesthesia with diazepam. Acta Anaesthesiol.Scand. (Suppl.) 24, 223 (1965).
THESLEFF, S.: The mode of neuromuscular block caused by acetylcholine, nicotine, decamethonium and succinylcholine. Acta Physiol. Scand. 34, 218 (1955).
TIMMERMAN, J.C., LONG, J.P., PITTINGER, C.B.: Neuromuscular blocking properties of various antibiotic agents. Toxic. Appl. Pharmacol. 1, 299 (1959).
TORDA, T.A., BURKHART, J., TOH, W.: The interaction of propanidid with suxamethonium and decamethonium. Anaesthesia 27, 159 (1972).
TORDA, T.A.G., FOLDES, F.F., BAILEY, R.J., KLONYMUS, D.H., KUWABARA, S.: The interactions of neuromuscular blocking agents in man: the role of hexafluorenium. Anesthesiology 28, 1010 (1967).
USUBIAGA, J.E., WIKINSKI, J.A.: Uso da procaina intravenosa em anestesia general. Rev.Brasil.Anest. 14, 400 (1964).
USUBIAGA, J.E. WIKINSKI, J.A., MORALES, R.L., USUBIAGA, L.E.J.: Interaction of intravenously administered procaine, lidocaine and succinylcholine in anesthetized subjects. Anesth.Anaig. 46, 39 (1967).
WALTS, L.F., DILLON, J.B.: The influenae of the anesthetic agent on the action of curare in man. Anest.Anaig. 49, 17 (1970).
WANG, R.I.H., ROSS, C.A.: Prolonged apnea following succinylcholine in cancer patients receiving AB-132. Anesthesiology 24, 363 (1963)
WAY, W.L., KATZUNG, B.G., LARSON, C.P.: Recurarization with quinidine. J.A.M.A. 200, 153 (1967).
WESCOE, W.C., RIKER, W.F.Jr.: The pharmacology of anticurare agents. Ann.N.Y.Acad.Sci. 54, 438 (1951).
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Foldes, F., Forbat, F. (1975). The Interactions Of Neuromuscular Blocking Agents With Anesthetic And Adjuvant Drugs. In: Bergmann, H., Blauhut, B. (eds) Anaesthesie und ZNS, Technische Gefahren der Anaesthesie, Medikamentöse Wechselwirkungen, Massivtransfusion. Anaesthesiology and Resuscitation/Anaesthesiologie und Wiederbelebung/Anesthésiologie et Réanimation, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66266-9_37
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