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Progress in Molecular and Subcellular Biology pp 227–248Cite as

Adenosine as a Physiological Regulator of Coronary Blood Flow

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 4))

Abstract

Coronary blood flow rate depends uniquely on myocardial oxygen consumption rate, as first demonstrated by ECKENHOFF et al. (1947) and confirmed by ALLELA et al. (1955) and RAYFORD et al. (1965). The energy to support the constant work of the heart comes from aerobic metabolism; fatty acids are the primary fuel, their oxidation accounting for about 70 percent of the oxygen the heart consumes (NEELY and MORGAN, 1974). Indeed, cardiac energy production is almost exclusively aerobic. Even maximally accelerated anerobic metabolism can furnish only 10–15 percent of the energy required to sustain cardiac performance.

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  1. Ray A. Olsson
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  2. Randolph E. Patterson
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Fred E. Hahn

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Olsson, R.A., Patterson, R.E. (1976). Adenosine as a Physiological Regulator of Coronary Blood Flow. In: Hahn, F.E. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66249-2_7

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