Inhibitors of DNA Synthesis in RNA Tumor Viruses: Biological Implications and Their Mode of Action

  • P. Chandra
  • Linda K. Steel
  • U. Ebener
  • M. Woltersdorf
  • H. Laube
  • G. Will
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 4)


More than four years have passed since University of Wisconsin Virologist HOWARD M. TEMIN disclosed at the 10th International Congress of Cancer that he and his coworkers had found preliminary evidence for an enzyme that permits ribonucleic acid (RNA) to dictate the synthesis of deoxyribonucleic acid (DNA). Independently the same phenomenon was observed by DAVID BALTIMORE (1970b) of the Massachussetts Institute of Technology. Although perhaps not as fundamental a concept as the α-helical structure of DNA, the RNA-dependent DNA polymerase (reverse transcriptase) is a concept that is shedding light on several unexplained biological phenomena and has already inspired biochemists, molecular biologists, virologists and even biophysicists to look into the mystic of this process. Thus, TEMIN’s discovery of “backward” transcription has set off an explosive and still unforseeable burst of activity in numerous laboratories.


Pyrrole Ring Rous Sarcoma Virus FEBS Letter Formyl Group Avian Myeloblastosis Virus 
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© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • P. Chandra
  • Linda K. Steel
  • U. Ebener
  • M. Woltersdorf
  • H. Laube
  • G. Will

There are no affiliations available

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