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Regulation of Bacteriophage T4 Gene Expression

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Progress in Molecular and Subcellular Biology

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 4))

Abstract

The lytic process of coliphage T4 begins with adsorption of the virion to the bacterial cell wall and subsequent injection of the viral DNA into the host (COHEN, 1963, 1968; MATHEWS, 1971). Synthesis of bacterial proteins stops within seconds (BENZER, 1953; BILEZIKIAN, KAEMPFER, and MAGASANIK, 1967; HAYWARD and GREEN, 1965; KAEMPFER and MAGASANIK, 1967; KENNELL, 1970; LEVIN and BURTON, 1961; ROUVIERE et al., 1968; SHER and MALLETTE, 1954). Bacterial DNA and RNA continue to be synthesized for several minutes, but at much-reduced rates (ADESNIK and LEVINTHAL, 1970; COHEN, 1963, 1968; KENNELL, 1968; LANDY and SPIEGELMAN, 1968; MATHEWS, 1971; NOMURA, HALL, and SPIEGELMAN, 1960; VOLKIN and ASTRACHAN, 1956). Transcription of the viral DNA begins immediately (OLESON, PISPA, and BUCHANAN, 1969) and the first viral proteins are completed less than one minute after infection (HOSODA and LEVINTHAL, 1968). Replication of the viral chromosome starts 5 min after infection but viral DNA replication does not reach its maximum rate until 10 min (COHEN, 1963, 1968; MATHEWS, 1971). Intracellular progeny viruses first appear 20 or so min after infection and their number increases steadily until 30 to 35 min, at which time the infected cell lyses (COHEN, 1963, 1968; MATHEWS, 1971).

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  1. Heman J. Witmer
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Witmer, H.J. (1976). Regulation of Bacteriophage T4 Gene Expression. In: Hahn, F.E. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66249-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-66249-2_2

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