Abstract
For a number of years there have been reports in literature on nephrotoxicity of methoxyflurane. Besides some clinical observations as, for instance, long persisting polyuria following methoxyflurane administration (3, 7), there are also hypotheses put forward referring the changes in the kidney function to the effect of the drug or its metabolites on the mechanism of urine condensation. A decreased sodium reabsorption in HENLE’s loop due to the disturbances in metabolism caused by the action of methoxyflurane or its metabolites might consequently give changes in the concentration of this ion in medullar part of the kidney thus secondarily disturbing the water absorption (5).
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© 1975 Springer-Verlag Berlin Heidelberg
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Knapowski, J., Jurczyk, W., Szulc, R. (1975). Effect of Methoxyflurane on Active Transport of Sodium in Isolated Epithelial Membrane. In: Bergmann, H., Blauhut, B. (eds) Intensivtherapie. Anaesthesiology and Resuscitation Anaesthesiologie und Wiederbelebung Anesthésiologie et Réanimation, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66246-1_31
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DOI: https://doi.org/10.1007/978-3-642-66246-1_31
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