Effect of Adalat (Nifedipine) on Left Ventricular Hemodynamics in Angina Pectoris (Comparative Study with Propranolol)

  • A. Kurita
  • M. Kanazawa
  • H. Hamamoto
  • G. Mabuchi
Conference paper


Recently in Japan there have been several papers published concerning the mechanism of action of nifedipine in animal experiments [7, 8] and its efficacy in angina pectoris in clinical studies [11]. Kimura et al. [10] studied its efficacy in treating angina pectoris by sequential analysis (Armitage); they concluded that it was almost as effective as isosorbide dinitrate and propranolol.


Angina Pectoris Venous Return Isosorbide Dinitrate Exercise Period Ischemic Heart Disease Patient 
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  1. 1.
    Benzing,G., Stockert, J., Nave, E., et al. : Evaluation of canine left ventricular contractility. Cardiovasc. Dis. 8, 313 (1974).Google Scholar
  2. 2.
    BRUCE, L., ROBINSON, P. H.: Medical management of angina pectoris. Circulation 41, 1132 (1972). Effect of Adalat on Left Ventricular Hemodynamics in Angina Pectoris 231Google Scholar
  3. 3.
    CONTI,C.R., GRABER,J.D., GUNDEL,W.D., et al. : Effect of pacing induced tachycardia on myocardial force-velocity relationships in man. Circulation (Abstr.) 46, 47 (Suppl. 111) (1970).Google Scholar
  4. 4.
    DWYER,E.M., WIENER,L., COX,J.W.: Effects of beta-adrenergic blockade (propranolol) on left ventricular hemodynamics and the electrocardiogram during exercise-induced angina pectoris. Circulation 38,250 (1968).PubMedGoogle Scholar
  5. 5.
    GAASCH,W.A., QUINONES,M.A., WAISSER,E., et al. : Alterations in the left ventricular contractile state during isometric exercise in patients with coronary artery disease. Amer. J. Cardiol. (Abstr.) 29,264 (1972).CrossRefGoogle Scholar
  6. 6.
    GRÜN,G., FLECKENSTEIN,A.: Die elektromechanische Entkoppelung der glatten Gefäß-muskulatur als Grundprinzip der Coronardilatation durch 4-(2’-nitrophenyl)-2,6-dimethyl-l,4-dihydropyridin-3,5-dicarbonsäure-dimethylester (BAY a 1040, Nifedipine). Arzneim.-Forsch. (Drug Res.) 22, 334 (1972).Google Scholar
  7. 7.
    HASHOMOTO,K., TAIRA,N.,CHIBA,S., et al. : Cardiohemodynamic effects of BAY a 1040 in the dog. Arzneim.-Forsch. (Drug Res.) 22,15 (1972).Google Scholar
  8. 8.
    HAYASE,S., HIRAKAWA,S.,HOSOKAWA,S., et al. : Basic and clinical studies on BAY a 1040 with special reference to its influence on the coronary systemic resistance and capacitance blood vessels. Jap. Heart J. 35,903 (1971).Google Scholar
  9. 9.
    KHAJA,P., PARKER,J.O., LEDWICH,J.J.: Assessment of ventricular function in coronary artery disease by means of atrial pacing and exercise. Amer. J. Cardiol. 26, 107 (1970).CrossRefPubMedGoogle Scholar
  10. 10.
    KIMURA,E., MABUCHI,G., KIKUCHI,H.: The clinical effect of 4-(2’-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-l,4-diphydropyridine (BAY a 1040) on angina pectoris evaluated by sequential analysis. Arzneim.-Forsch. (Drug Res.) 22,365 (1972).Google Scholar
  11. 11.
    KOBAYASHI,T., ITO,Y., TAWARA,I.: Clinical experience with a new coronary-active substance (BAY a 1040). Arzneim.-Forsch. (Drug Res.) 22,380 (1972).Google Scholar
  12. 12.
    MASON, D.T.: Usefulness and limitation of the rate of rise of intraventricular pressure (dp/dt) in the evaluation of myocardial contractility in man. Amer. J. Cardiol. 23, 516 (1969).CrossRefPubMedGoogle Scholar
  13. 13.
    PARKER, J. O., GIORGI,S.D., WEST,R.O.: A hemodynamic study of acute coronary insufficiency precipitated by exercise. With observations on the effects of nitroglycerin. Amer. J. Cardiol. 17,470(1966).CrossRefPubMedGoogle Scholar
  14. 14.
    PARKER,J. O., WEST,R.O., GIORGI,S.D.: The hemodynamic response to exercise in patients with healed myocardial infarction without angina. With observations on the effects of nitroglycerin. Circulation 36,734 (1967).PubMedGoogle Scholar
  15. 15.
    PARKER, J. O., WEST,R.O., GIORGI,S.D.: Hemodynamic effects of propranolol in coronary heart disease. Amer. J. Cardiol. 21, 11 (1968).CrossRefPubMedGoogle Scholar
  16. 16.
    QUINONES,M.A., GAASCH,W.H., WAISSER,E., et al. : An analysis of left ventricular response to isometric exercise. Amer. Heart J. 88,29 (1974).CrossRefPubMedGoogle Scholar
  17. 17.
    WIENER,C., DWYER,E.M.,JR., COX,J.W.: Left ventricular hemodynamics in exerciseinduced angina pectoris. Circulation 38,240 (1969).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • A. Kurita
    • 1
  • M. Kanazawa
    • 2
  • H. Hamamoto
    • 2
  • G. Mabuchi
    • 2
  1. 1.Cedars Sinai Medical CenterLos AngelesUSA
  2. 2.Nippon Medical SchoolTokyoJapan

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