Abstract
Already in 1943 MARTINI, GUALTIEROTTI and MARZORATI (18) observed an anesthetic effect of repetitive electrical current application to the cat’s spinal cord. There has been renewed interest in this phenomenon recently, when electrical stimulation of the spinal cord (e.g. the dorsal columns) and of peripheral nerves was used in man for the relief from chronic pain (c.f. the clinical reports to this meeting). What is the neurophysiological basis of this beneficial therapeutic method?
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Beck, P.W., Handwerker, H.O., Zimmermann, M.: Nervous outflow from the cat’s foot during noxious radiant heat stimulation. Brain Res. 67, 373–386 (1974).
Bessou, P., Perl, E.R.: Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurophysiol. 32, 1025–1043 (1969).
Burgess, E.R., Perl, E.R.: Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J. Physiol. 190, 541–562 (1967).
Burke, R.E., Rudomin, P., Vycklicky, L., Zajac III, F.E.: Primary afferent depolarization and flexion reflexes produced by radiant heat stimulation of the skin. J. Physiol. 213, 185–214 (1971).
Cannon, W.B., Rosenblueth, A.: The supersensitivity of denervated structures. New York: MacMillan 1949.
Cass, D.T., Sutton, T.J., Mark, R.F.: Competition between nerves for functional connexions with Axolotl muscles. Nature 243, 201–203 (1973).
Christensen, B.N., Perl, E.R.: Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn. J. Neurophysiol. 33, 293–307 (1970).
Goldberger, M.E., Murray, M.: Restitution of function and collateral sprouting in the cat spinal cord: the de-afferented animal. J. Comp. Neurol. 158, 37–54 (1974).
Gregor, M., Zimmermann, M.: Characteristics of spinal neurones responding to cutaneous myelinated and unmyelinated fibres. J. Physiol. 221, 555–576 (1972).
Gregor, M., Zimmermann, M.: Dorsal root potentials produced by afferent volleys in cutaneous Group III fibres. J. Physiol. 232, 413–425 (1973).
Guth, L.: Axonal regeneration and functional plasticity in the central nervous system. Exp. Neurol. 45, 606–654 (1974).
Handwerker, H.O., Iggo, A., Zimmermann, M.: Segmental and supraspinal actions on dorsal horn neurons responding to nocuous and non-nocuous skin stimuli. Pain 1, (in press).
Hassler, R.: Die zentralen Systeme des Schmerzes. Acta Neuro-chirurgica, Vol. 7, 354–423 (1960).
HEES, J. Van, Gybels, J.M.: Pain related to single afferent C fibers from human skin. Brain Res. 48, 397–400 (1972).
Kjerulf, T.D., Loeser, J.D.: Neuronal hyperactivity following deaf ferentation of the lateral cuneate nucleus. Exp. Neurol. 39, 70–85 (1973).
Loeser, J.D., Ward, A.A., Jr.: Some effects of deafferentation on neurons of the cat spinal cord. Arch. Neurol. 17, 629–636 (1967).
Lømo, T., Rosenthal, J.: Control of ACh sensitivity by muscle activity in the rat. J. Physiol. 221, 493–513 (1972).
Martini, E., Gualtierotti, T., Marzorati, A.: Die RĂ¼ckenmarkelektronarkose. PflĂ¼gers Arch. ges. Physiol. 246, 585–596 (1943).
Melzack, R., Wall, P.D.: Pain mechanisms: A new theory. Science 150, 971–979 (1965).
Nathan, P.W., RĂ¼deg, P.: Testing the gate-control theory of pain in man. J. Neurol. Neurosurg. Psychiat. 37, 1366–1372 (1974).
Nyquist, J.K., Greenhoot, J.H.: A single neuron analysis of mesencephalic reticular formation responses to high intensity cutaneous input in cat. Brain Res. 70, 157–164 (1974).
Oliveras, J.L., Besson, J.M., Guilbaud, G., Liebeskind, J.C.: Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat. Exp. Brain Res. 20, 32–44 (1974).
Rang, H.P., Ritchie, J.M.: On the electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations. J. Physiol. 196, 183–221 (1968).
Selzer, M., Spencer, W.A.: Convergence of visceral and cutaneous afferent pathways in the lumbar spinal cord. Brain Res. 14, 331–348 (1969).
Selzer, M., Spencer, W.A.: Interactions between visceral and cutaneous afferents in the spinal cord: reciprocal primary afferent fibre depolarization. Brain Res. 14, 349–366 (1969).
Stavraky, G.W.: Supersensitivity following lesions of the nervous system. Toronto: Univ. of Toronto Press 1961.
Torebjörk, H.E., Hallin, R.G.: Identification of the afferent C units in intact human skin nerves. Brain Res. 67, 387–404 (1974).
Wall, P.D., Gutnick, M.: Properties of afferent nerve impulses originating from a neuroma. Nature 248, 740–743 (1974).
Zimmermann, M.: Dorsal root potentials after C-fiber stimulation. Science 160, 896–898 (1968).
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Zimmermann, M. (1975). Neurophysiological Models for Nociception, Pain, and Pain Therapy. In: Penzholz, H., Brock, M., Hamer, J. (eds) Brain Hypoxia. Advances in Neurosurgery, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66239-3_28
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DOI: https://doi.org/10.1007/978-3-642-66239-3_28
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