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Abstract

Many RNA and DNA tumor viruses induce neoplastic transformation in vitro, but few of these are leukemia viruses acting on hematopoietic target cells. The virus of avian myeloblastosis (AMV) is such an agent, capable of producing morphological changes in hematopoietic tissues grown in vitro, and thus provides an excellent model to study leukemia induction at the cellular level.

This work was supported by the Veterans Administration (MRIS 5855), by the Anna Fuller Fund, and by Grant CA-10697 of the National Cancer Institute.

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References

  • Baluda, M. A.: Properties of cells infected with avian myeloblastosis virus. Cold Spring Harbor Symp. Quant. Biol. 27, 415–425 (1962)

    PubMed  CAS  Google Scholar 

  • Baluda, M. A.: The role of the bursa-dependent lymphoid tissue in oncogenesis by avian myeloblastosis virus. Virology 32, 428–437 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Baluda, M. A., Goetz, I. E.: Morphological conversion of cell cultures by avian myeloblastosis virus. Virology 15, 185–199 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Baluda, M. A., Jamieson, P. P.: In vivo infectivity studies with avian myeloblastosis virus. Virology 14, 33–45 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Baluda, M. A., Moscovici, C., Goetz, I. E.: Specificity of the in vitro inductive effect of avian myeloblastosis virus. N. C. I. Monograph 17, 449–458 (1964)

    Google Scholar 

  • Beard, J. W.: Avian virus growths and their etiological agents. Adv. Cancer Res. 7, 1–127 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Beaudreau, G. S., Becker, C.: Virus of avian myeloblastosis. X. Photometric micro-determination of adenosine triphosphatase activity. J. Nat. Cancer Inst. 20 (2), 339–349(1958)

    PubMed  CAS  Google Scholar 

  • Beaudreau, G. S., Becker, C., Bonar, R. A., Wallbank, A. M., Beard, D., Beard, J.W.: Virus of avian myeloblastosis. XIV. Neoplastic response of normal chicken bone marrow treated with the virus in tissue culture. J. Nat. Cancer Inst. 24, 395–415 (1960)

    PubMed  CAS  Google Scholar 

  • Bradley, T. R., Metcalf, D.: The growth of mouse bone marrow cells in vitro. Aust. J. Exp. Biol. Med. Sci. 44, 287–299 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Burmester, B. R.: Transmission of tumor-inducing avian viruses under natural conditions. Texas Reports Biol. and Med. 15, 540–558 (1957)

    CAS  Google Scholar 

  • Crittenden, L. B., Okazaki, W., Reamer, R. H.: Genetic resistance to Rous sarcoma virus in embryo cell cultures and embryos. Virology 20, 541–544 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Crittenden, L. B., Stone, H. A., Reamer, R. H., Okazaki, W.: Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses. J. Virol. 1, 898–904 (1967)

    PubMed  CAS  Google Scholar 

  • Crittenden, L. B., Wendel, E. J., Motta, J. V.: Interaction of genes controlling resistance to RSV (RAV-0). Virology 52, 373–384 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Davis, B. D., Dulbecco, R., Eisen, H. N., Ginsberg, H. S., Wood, W. B., Jr., McCarty, M.: Microbiology, 2nd ed., pp. 1042–1045, Ch. 44. New York: Harper and Row 1973

    Google Scholar 

  • de-Thé, G.: Localization and origin of the adenosinetriphosphatase activity of avian myeloblastosis virus. A Review. N.C.I. Monograph 17, 651–671 (1964)

    Google Scholar 

  • Dodge, W. H., Moscovici, C.: Colony formation by chicken hematopoietic cells and virus-induced myeloblasts. J. Cell Physiol. 81, 371–386 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Dodge, W. H., Silva, R. F., Moscovici, C.: The origin of chicken hematopoietic colonies as assayed in semi-solid agar. J. Cell Physiol. 85, 25–30 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Doljanski, L., Pikovski, M.: Agent of fowl leukosis in tissue cultures. Cancer Res. 2, 626–631 (1942)

    Google Scholar 

  • Dougherty, R. M., Rasmussen, R.: Properties of a strain of Rous sarcoma virus that infects mammals. N.C.I. Monograph 17, 337–350 (1964)

    Google Scholar 

  • Duff, R. G., Vogt, P. K.: Characteristics of two new avian tumor virus subgroups. Virology 39, 18–30 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Eckert, E. A., Beard, D., Beard, J. W.: Dose-response relations in experimental transmission of avian erythromyeloblastic leukosis. I. Host response to the virus. J. Nat. Cancer Inst. 12, 447–463 (1951)

    PubMed  CAS  Google Scholar 

  • Eckert, E. A., Beard, D., Beard, J. W.: Dose-response relations in experimental transmission of avian erythromyeloblastic leukosis. III. Titration of virus. J. Nat. Cancer Inst. 14, 1055–1066 (1954)

    PubMed  CAS  Google Scholar 

  • Ellerman, V., Bang, O.: Experimentelle Leukämie bei Hühnern. Centre F. Bakteriol. Parasitenk. Abt. 1 46, 595–609 (1908)

    Google Scholar 

  • Fujita, D. J., Chen, Y. C., Friis, R. R., Vogt, P. K.: RNA tumor viruses of pheasants: Characterization of avian leukosis subgroups F and G. Virology 60, 558–571 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Gazzolo, L., Moscovici, M. G., Moscovici, C.: Replication of avian sarcoma viruses in chicken macrophages. Virology 58, 514–525 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Gordon, S., Cohn, Z. A.: The macrophage. Int. Rev. Cytol. 36, 171–214 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Graf, T.: A plaque assay for RNA tumor viruses. Virology 50, 567–578 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Graf, T.: Two types of target cells for transformation with avian myelocytomatosis virus. Virology 54, 398–413 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Greenwood, A. W., Blyth, J. S. S., Carr, J. C.: Indications of the heritable nature of nonsusceptibility to Rous sarcoma in fowls. Brit. J. Cancer 2, 135–142 (1948)

    Article  PubMed  CAS  Google Scholar 

  • Hall, W. J., Bean, C. W., Pollard, M.: Transmission of fowl leukosis through chick embryos and young chicks. Amer. J. Vet. Res. 2, 272–279 (1941)

    Google Scholar 

  • Hanafusa, H.: Nature of the defectiveness of Rous sarcoma virus. Nat. Cancer Inst. Monogr. 17, 543–556 (1964)

    Google Scholar 

  • Hanafusa, H.: Analysis of the defectiveness of Rous sarcoma virus. III. Determining influence of a new helper virus on the host range and susceptibility to interference of RSV. Virology 25, 248–255 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Hanafusa, H.: Virus production by Rous sarcoma cells. Curr. Top. Microbiol. Immunol. 51, 114–123 (1970)

    PubMed  CAS  Google Scholar 

  • Hanafusa, H., Hanafusa, T.: Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals. Proc. Nat. Acad. Sci. 55, 532–538 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Hanafusa, T., Hanafusa, H.: Isolation of leukosis-type virus from pheasant embryo cells: Possible presence of viral genes in cells. Virology 51, 247–251 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Hanafusa, T., Hanafusa, H., Miyamoto, T.: Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses. Proc. Nat. Acad. Sci. 67, 1797–1803 (1970a)

    Article  PubMed  CAS  Google Scholar 

  • Hanafusa, T., Miyamoto, T., Hanafusa, H.: A type of chick embryo cell that fails to support formation of infectious RSV. Virology 40, 55–64 (1970b)

    Article  PubMed  CAS  Google Scholar 

  • Ichikawa, Y.: Differentiation of a cell line of myeloid leukemia. J. Cell Physiol. 74, 223–234 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Ichikawa, Y.: Further studies on the differentiation of a cell line of myeloid leukemia. J. Cell Physiol. 76, 175–184 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Ichikawa, Y., Pluznik, D. H., Sachs, L.: In vitro control of the development of macrophage and granulocyte colonies. Proc. Nat. Acad. Sci. 56, 488–495 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Johnson, E. P.: Fowl leukosis-manifestations, transmission, and etiological relationship of various forms. Virginia Agricultural Experiment Station Technical Bulletin 76, 3–21 (1941)

    Google Scholar 

  • Kawai, S., Hanafusa, H.: Genetic recombination with avian tumor virus. Virology 49, 37–44 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Lagerlöf, B.: In vitro and in vivo investigations of fowl erythroleukemia. Acta Path. Microb. Scand. 49, Supplement No. 138 (1960)

    Google Scholar 

  • Metcalf, D.: Human leukaemia: Recent tissue culture studies on the nature of myeloid leukaemia. Brit. J. Cancer 27, 191–202 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Metcalf, D., Moore, M. A. S.: Haemopoietic cells. Amsterdam-London: North-Holland 1971

    Google Scholar 

  • Mommaerts, E. B., Sharp, D. G., Eckert, E. A., Beard, D., Beard, J. W.: Virus of avian erythromyeloblastic leukosis. I. Relation of specific plasma particles to dephosphorylation of adenosine triphosphate. J. Nat. Cancer Inst. 14, 1011–1025 (1954)

    PubMed  CAS  Google Scholar 

  • Moscovici, C.: A quantitative assay for avian myeloblastosis virus. Proc. Soc. Exp. Biol. Med. 125, 1213–1215 (1967)

    PubMed  CAS  Google Scholar 

  • Moscovici, C., MacIntyre, E. H.: Effect of avian myeloblastosis virus in the Japanese quail. J. Bact. 92, 1141–1149 (1966)

    PubMed  CAS  Google Scholar 

  • Moscovici, C., Moscovici, M. G.: Tissue culture of avian hematopoietic cells. In “Methods in Cell Biology”. Vol. VII, D. M. Prescott (ed.). pp. 313–328. New York-London: Academic Press 1973

    Google Scholar 

  • Moscovici, C., Moscovici, M. G., Zanetti, M.: Transformation of chick fibroblast cultures with avian myeloblastosis virus. J. Cell Physiol. 73, 105–108 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Moscovici, C., Vogt, P. K.: Effects of genetic cellular resistance on cell transformation and virus replication in chicken hematopoietic cell cultures infected with avian myeloblastosis virus (BAI-A). Virology 35, 487–497 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Moscovici, C., Zanetti, M.: Studies on single foci of hematopoietic cells transformed by avian myeloblastosis virus. Virology 42, 61–67 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Oberling, C., Guerin, M., Guerin, P.: Influence de la quinine et de ses derivés sur la leucémie transmissible des poules. C. R. Soc. Biol. 116, 799–802 (1934)

    CAS  Google Scholar 

  • Olson, C., Jr.: Transmissible fowl leukosis. A review of the literature. Mass. Agr. Exp. Sta. Bull. 370 (1940)

    Google Scholar 

  • Payne, L. N., Biggs, P. M.: Genetic resistance of fowl to MH2 reticuloendothelioma virus. J. Gen. Virol. 7, 177–185 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Pike. B. L., Robinson, W. A.: Human bone marrow colony growth in agar gel. J. Cell Physiol. 76, 77–84 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Ponten, J.: Spontaneous and virus induced transformation in cell culture. Virology Monographs 8, 1–253. Berlin-Heidelberg-New York: Springer 1971

    CAS  Google Scholar 

  • Reed, L. H., Muench, H.: A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27, 493–497 (1938)

    Google Scholar 

  • Romanoff, A. L.: The avian embryo. New York: Macmillan 1960

    Google Scholar 

  • Rubin, H.: The immunological basis for non-infective Rous sarcomas. Cold Spring Harbor Symp. Quant Biol. 27, 441–452 (1962)

    PubMed  CAS  Google Scholar 

  • Rubin, H.: Genetic control of cellular susceptibility to pseudotypes of Rous sarcoma virus. Virology 26, 270–276 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Silva, R. F., Dodge, W. H., Moscovici, C.: The role of humoral factors in the regression of leukemia in chickens as measured by in vitro colony formation. J. Cell Physiol. 83, 187–191 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Silva, R. F., Moscovici, C.: Spontaneous regression of leukemia in chickens infected with avian myeloblastosis virus. Proc. Soc. Exp. Biol. Med. 143, 604–611 (1973)

    PubMed  CAS  Google Scholar 

  • Smith, R. E., Moscovici, C.: The oncogenic effects of nontransforming viruses from avian myeloblastosis virus. Cancer Res. 29, 1356–1366 (1969)

    PubMed  CAS  Google Scholar 

  • Stenkvist, B. L., Ponten, J.: Growth curves, histology and virus titers in Rous sarcomas. A comparison between progressively growing and regressing tumours. Acta Pathol. Microbiol. Scand. 58, 273–282 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Temin, H.: Mechanism of cell transformation by RNA tumor viruses. Ann. Rev. Microb. 25, 609–648 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Temin, H., Rubin, H.: Characteristics of an assay of Rous sarcoma virus and Rous sarcoma cells in tissue culture. Virology 6, 669–688 (1958)

    Article  PubMed  CAS  Google Scholar 

  • Vigier, P.: RNA oncogenic viruses: Structure, replication, and oncogenicity. Prog. Med. Virol. 12, 240–283 (1970)

    PubMed  CAS  Google Scholar 

  • Vogt, P. K.: The infection of chicken fibroblast cultures by avian myeloblastosis virus. In “Viruses, Nucleic Acids, and Cancer”, pp. 374–386. Baltimore, Md.: Williams and Wilkins 1963

    Google Scholar 

  • Vogt, P. K.: Avian tumor viruses. Adv. Virus Res. 11, 293–385 (1965a)

    Article  PubMed  CAS  Google Scholar 

  • Vogt, P. K.: A heterogeneity of Rous sarcoma virus revealed by selectively resistant chick embryo cells. Virology 25, 237–267 (1965b)

    Article  PubMed  CAS  Google Scholar 

  • Vogt, P. K.: A virus released by “nonproducing” Rous sarcoma cells. Proc. Nat. Acad. Sci. 58, 801–808 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Vogt, P. K.: Focus assay of Rous sarcoma virus. In “Fundamental Techniques in Virology”, K. Habel and N. P. Salzman (eds.), pp. 198–211. New York: Academic Press 1969

    Google Scholar 

  • Vogt, P. K.: Envelope classification of avian RNA tumor viruses. In “Proc. IVth Int. Symp. Comp. Leuk. Research”, Cherry Hill, N. J., Bibl. Hemat. No. 36, 1 53–167 (1970)

    Google Scholar 

  • Vogt, P. K.: Genetically stable reassortaient of markers during mixed infection with avian tumor viruses. Virology 46, 947–952 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Vogt, P. K., Ishizaki, R.: Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens. Virology 26, 664–672 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Vogt, P. K., Ishizaki, R.: Criteria for the classification of avian tumor viruses. In “Viruses Inducing Cancer”, W. J. Burdette (ed.), pp. 71–90. Salt Lake City, Utah: Univ. of Utah Press, 1966a

    Google Scholar 

  • Vogt, P. K., Ishizaki, R.: Patterns of viral interference in the avian leukosis and sarcoma complex. Virology 30, 368–374 (1966b)

    Article  PubMed  CAS  Google Scholar 

  • Vogt, P. K., Rubin, H.: Studies on the assay and multiplication of avian myeloblastosis virus. Virology 19, 92–104 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Walter, W. G., Burmester, B. R., Cunningham, H.: Studies on the transmission and pathology of a viral-induced avian nephroblastoma (embryonal nephroma). Avian Dis. 6, 455–477 (1962)

    Article  Google Scholar 

  • Waters. N. F., Burmester, B. R.: Mode of inheritance of resistance to Rous sarcoma virus. J. Nat. Cancer Inst. 27, 655–662 (1961)

    PubMed  CAS  Google Scholar 

  • Weiss, R. A.: Spontaneous virus production from “non-virus producing” Rous sarcoma cells. Virology 32, 719–722 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Weiss, R. A.: The host range of Bryan strain Rous sarcoma virus synthesized in the absence of helper virus. J. Gen. Virol. 5, 529–539 (1969)

    Article  Google Scholar 

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Moscovici, C. (1975). Leukemic Transformation with Avian Myeloblastosis Virus: Present Status. In: Arber, W., et al. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66193-8_2

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