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Animal Models for Atherosclerosis Research

  • Chapter
Hypolipidemic Agents

Abstract

Human atherosclerosis is a complex, progressive disease process of multiple etiology. There are a number of initiating factors, at least as many augmenting factors and the extent of their interaction is undoubtedly different for every individual. The extent of atherosclerotic involvement in any specific individual is not easily assessed and is essentially masked until it precipitates a clinical event. Thus, research in this field must be carried out using appropriate animal models.

Supported in part by USPHS grants HL 03299, HL 05209 and a Research Career Award HL 0734 from the National Heart and Lung Institute.

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References

  • Altscxul, R.: Selected Studies on Arteriosclerosis. Springfield, Illinois. C. C. Thomas 1950.

    Google Scholar 

  • Anirscxxow, N.: Über die Veränderungen der Kaninchenaorta bei experimenteller Cholesterinsteatose. Beitr. Path. Anat. 56, 379–404 (1913).

    Google Scholar 

  • Anitschkow, N.: Experimental arteriosclerosis in animals. In: Cowdry, E. V. (Ed.): Arteriosclerosis: A Survey of the Problem, pp. 271–322. New York: MacMillan Co. 1933.

    Google Scholar 

  • Armstrong, M. L., Megan, M. B.: Lipid depletion in atheromatous coronary arteries in rhesus monkeys after regression diets. Circulation Res. 30, 675–680 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Armstrong, M. L., Warner, E. D.: Morphology and distribution of diet induced atherosclerosis in rhesus monkeys. Arch. Path. 92, 395–101 (1971).

    PubMed  CAS  Google Scholar 

  • Armstrong, M. L., Warner, E. D., Connor, W. E.: Regression of coronary atheromatosis in rhesus monkeys. Circulation. Res. 27, 59–67 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Aubert, D., Ferrand, J. C., Lacaze, B., Pepin, O., Panak, E., Podesta, M.: Athérogénèse expérimentale chez le rat Wistar. Atherosclerosis 20, 263–280 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Brohon, J., Chomette, G., Sterne, J.: Technique accéléree de production d’une athérosclérose expérimentale chez la lapin. Paroi Arterielle 2, 18–27 (1974).

    Google Scholar 

  • Bullock, B. C., Clarkson, T.B., Lehner, N. D. M., Lofland, H.B. Jr., St. Clair, R. W.: Atherosclerosis in Cebus albifrons monkeys. III. Clinical and pathological studies. Exp. molec. Path. 10, 39–62 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Clarkson, T.B.: Atherosclerosis—spontaneous and induced. Advanc. Lipid Res. 1, 211–252 (1963).

    CAS  Google Scholar 

  • Clarkson, T. B., King, J. S., Jr., Lofland, H. B., Feldner, M. A., Bullock, B. C.: Pathologic characteristics and composition of diet aggravated atherosclerotic plaques during “regression”. Exp. molec. Path. 19, 267–283 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Clarkson, T. B., Prichard, R. W., Netsky, M. G., Lofland, H.B.: Atherosclerosis in pigeons: Its spontaneous occurence and resemblance to human atherosclerosis. Arch. Path. 68, 143–147 (1959).

    CAS  Google Scholar 

  • Constantinides, P.: Experimental Atherosclerosis. Amsterdam: Elsevier Publ. Co. 1965.

    Google Scholar 

  • Daoud, A.S., Jarmolych, J., Fritz, K., Augustyn, J.: Regression of advanced atherosclerosis in swine (morphologic studies). Circulation 49, 92 (1974).

    Google Scholar 

  • Depalma, R. G., Insull, W., Bellon, E. M., Roth, W. T., Robinson, A. V.: Animal models for the study of progression and regression of atherosclerosis. Surgery 72, 268–278 (1972).

    PubMed  CAS  Google Scholar 

  • Diluzio, N.R., O’neal, R. M.: The rapid development of arterial lesions in dogs fed an “Infarct-producing” diet. Exp. molec. Path. 1, 122–132 (1962).

    Article  CAS  Google Scholar 

  • Downie, H. G., Mustard, J. F., Rowsell, H. C.: Swine atherosclerosis: The relationship of lipids and blood coagulation to its development. Ann. N. Y. Acad. Sci. 104, 539–562 (1963).

    Article  CAS  Google Scholar 

  • Dreizen, S., Levy, B.M., Bernick, S.: Diet-induced atherosclerosis in the marmoset. Proc. Soc. exp. Biol. (N.Y.) 143, 1218–1223 (1973).

    Article  CAS  Google Scholar 

  • Eggen, D. A., Strong, J.P., Newman, W. P. III, Catsulis, C., Malcom, G.T., Kokatnur, M. G.: Regression of diet-induced fatty streaks in rhesus monkeys. Lab. Invest. 31, 294–301 (1974).

    PubMed  CAS  Google Scholar 

  • Fillios, L. C., Mann, G. V.: The importance of sex in the variability of the cholesteremic response of rabbits fed cholesterol. Circulation Res. 4, 406–412 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Gillman, J., Gilbert, C.: Atherosis in the baboon (Papio ursinus) its pathogenesis and etiology. Exp. Med. Surg. 15, 181–221 (1957).

    PubMed  CAS  Google Scholar 

  • Giordano, A.R., Spraragen, S. C., Hamel, H.: A model for the rapid production of atheromatous lesions in rabbits. Lab. Invest. 22, 94–99 (1970).

    PubMed  CAS  Google Scholar 

  • Gottlieb, H., Lalich, J.J.: The occurence of arteriosclerosis in the aorta of swine. Amer. J. Path. 30, 851–855 (1954).

    PubMed  CAS  PubMed Central  Google Scholar 

  • Gresham, G.A., Howard, A.N., Mcqueen, J., Bowyer, D.E.: Atherosclerosis in primates. Brit. J. exp. Path. 46, 94–103 (1965).

    PubMed  CAS  PubMed Central  Google Scholar 

  • Gupta, P.P., Tandon, H. D., Ramalingaswami, V.: Further observations on the reversibility of experimentally induced atherosclerosis in rabbits. J. Path. 105, 229–238 (1971).

    Article  PubMed  CAS  Google Scholar 

  • >Guski, H., Weiss, R.: Zur Frage der spontanen Rückbildungsfähigkeit der experimentellen Atheromatose. Exp. Path. 6, 214–224 (1972).

    CAS  Google Scholar 

  • Hartroft, W.S., Ridout, J.H., Sellars, E.A., Best, C.H.: Atheromatous changes in aorta, carotid and coronary arteries of choline-deficient rats. Proc. Soc. exp. Biol. (N.Y.) 81, 384–393 (1952).

    Article  CAS  Google Scholar 

  • Hartroft, W. S., Thomas, W.A.: Induction of experimental atherosclerosis in various animals. In: Sandler, M., Bourne, G.H.: (Eds.): Atherosclerosis and its Origin, pp. 439–457. New York: Academic Press, Inc. 1963.

    Google Scholar 

  • Hirsch, R.L., Itellner, A.: The pathogenesis of hyperlipemia induced by means of surface-active agents. II. Failure of exchange of cholesterol between plasma and the liver in rabbits given Triton WR-1339. J. exp. Med. 104, 15 24 (1956).

    Google Scholar 

  • Ignatowski, A.: Über die Wirkung des tierschen Eiweißes auf die Aorta and die parenchymatosen Organe der Kaninchen. Arch. Path. Anat. Physiol. 198, 248–270 (1909).

    Article  Google Scholar 

  • Katz, L. N., Stamler, J.: Experimental Atherosclerosis. Springfield, Ill.: C. C. Thomas 1953.

    Google Scholar 

  • Kellner, A., Correll, J. W., Ladd, A.T.: Sustained hyperlipemia induced in rabbits by means of intravenously injected surface-active agents. J. exp. Med. 93, 373–383 (1951).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Koletsky, S.: Obese spontaneously hypertensive rats.-A model for study of atherosclerosis. Exp. molec. Path. 19, 53–60 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D.: Experimental atherosclerosis in rabbits fed cholesterol-free diets. J. Atheroscler. Res. 4, 103–105 (1964a).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D.: Experimental Atherosclerosis. In: Paoletti, R. (Ed.) Lipid Pharmacology, pp. 63–130. New York: Academic Press, Inc. 1964b.

    Chapter  Google Scholar 

  • Kritchevsky, D.: Role of cholesterol vehicle in experimental atherosclerosis. Amer. J. clin. Nutr. 23, 1105–1110 (1970).

    PubMed  CAS  Google Scholar 

  • Kritchevsky, D.: Laboratory models for atherosclerosis. Advanc. Drug Res. 9, 41–53 (1974).

    CAS  Google Scholar 

  • Kritchevsky, D., Davidson, L. M., Shapiro, I. L., Kim, H. K., Kitagawa, M., Malhotra, S., Nair, P. P., Clarkson, T. B., Bersohn, I., Winter, P.A.D.: Lipid metabolism and experimental atherosclerosis in baboons: Influence of cholesterol-free, semi-synthetic diets. Amer. J. clin. Nutr. 27, 29–50 (1974a).

    CAS  Google Scholar 

  • Kritchevsky, D., Davidson, L. M., Vanderwatt, J. J., Winter, P. A. D., Bersohn, I.: Hyper Chlesterolaemia and atherosclerosis induced in vervet monkeys by cholesterol-free, semisynthetic diets. S. Afr. Med. J. 48, 2413–2414 (1974b).

    CAS  Google Scholar 

  • Kritchevsky, D., Kim, H. K., Tepper, S.A.: Effect of colestipol (U-26, 597A) on experimental atherosclerosis in rabbits. Proc. Soc. exp. Biol. (N.Y.) 142, 185–188 (1973c).

    Article  CAS  Google Scholar 

  • Kritchevsky, D., Langan, J., Markowitz, J., Berry, J. F., Turner, D.A.: Cholesterol vehicle in experimental atherosclerosis. III. Effects of absence or presence of fatty vehicle. J. Amer. Oil chem. Soc. 38, 74–76 (1961a).

    Article  CAS  Google Scholar 

  • Kritchevsky, D., Moyer, A. W., Tesar, W.C., Logan, J. B., Brown, R. A., Davies, M. C., Cox, H. R.: Effect of cholesterol vehicle in experimental atherosclerosis. Amer. J. Physiol. 178, 30–32 (1954).

    PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Moyer, A. W., Tesar, W.C., Mcandless, R. F. J., Logan, J.B., Brown, R. A., Englert, M. E.: Cholesterol vehicle in experimental atherosclerosis. II. Influence of unsaturation. Amer. J. Physiol. 185, 279–280 (1956).

    PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Moynihan, J. L., Langan, J., Tepper, S.A., Sachs, M. L.: Effects of d- and l-thyroxine and of d- and l-3,5,3′-triiodothyronine on development and regression of experimental atherosclerosis in rabbits. J. Atheroscler. Res. 1, 211–221 (1961b).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Sallata, P., Tepper, S. A.: Experimental atherosclerosis in rabbits fed cholesterol-free diets. 2. Influence of various carbohydrates. J. Atheroscler. Res. 8, 697–703 (1968a).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Sallata, P., Tepper, S.A.: Influence of ethyl p-chlorophenoxy-isobutyrate (CPIB) upon establishment and progression of experimental atherosclerosis in rabbits. J. Atheroscler. Res. 8, 755–761 (1968c).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A.: Factors affecting atherosclerosis in rabbits fed cholesterol-free diets. Life Sci. 4, 1467–1471 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A.: Influence of D- and l-thyroxine on pre-established atheroma in rabbits: Effect of mode of administration. J. Atheroscler. Res. 7, 103–110 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A.: Experimental atherosclerosis in rabbits fed cholesterol-free diets: Influence of chow components. J. Atheroscler. Res. 8, 357–369 (1968b).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A.: Cholesterol vehicle in experimental atherosclerosis. 14. Diet and rate of appearance of atheromata. Nutrition Reports Int. 8, 163–168 (1973a).

    CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A., Kitagawa, M.: Experimental atherosclerosis in rabbits fed cholesterol-free diets. 3. Comparison of fructose and lactose with other carbohydrates. Nutrition Reports Int. 7, 193–202 (1973b).

    CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A., Langan, J.: Cholesterol vehicle in experimental atherosclerosis. IV. Influence of heated fat and fatty acids. J. Atheroscler. Res. 2, 115–122 (1962).

    Article  CAS  Google Scholar 

  • Kritchevsky, D., Tepper, S.A., Vesselinovitch, D., Wissler, R. W.: Cholesterol vehicle in experimental atherosclerosis. 11. Peanut oil. Atherosclerosis 14, 53–64 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Laird, C. W., Fox, R. R., Schultz, H. S., Mitchell, B. P., Blau, E. M.: Strain variations in rabbits: biochemical indicators of thyroid functions. Life Sci. 9, 203–214 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Lambert, G. F., Miller, J. P., Olsen, R. T., Frost, D. V.: Hypercholesteremia and atherosclerosis induced in rabbits by purified high fat rations devoid of cholesterol. Proc. Soc. exp. Biol. (N.Y.) 97, 544–549 (1958).

    Article  CAS  Google Scholar 

  • Lee, K.T., Jarmolych, J., Kim, D. N., Grant, C., Krasney, J. A., Thomas, W. A., Bruno, A. M.: Production of advanced atherosclerosis, myocardial infarction and “sudden death” in swine. Exp. molec. Path. 15, 170–190 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Lindsay, S., Nichols, C.W., Jr.: Arteriosclerosis in the pigeon: Naturally occurring disease of the coronary arteries and aorta. Exp. Med. Surg. 29, 42–60 (1971).

    PubMed  CAS  Google Scholar 

  • Lofland, H.B., Clarkson, T. B.: Biochemical study of spontaneous atherosclerosis in pigeons. Circulation Res. 7, 234–237 (1959).

    Article  PubMed  Google Scholar 

  • Lofland, H. B., St. Clair, R. W., Macnintch, J. E., Prichard, R. W.: Atherosclerosis in new world primates: Biochemical studies. Arch. Path. 83, 211–214 (1967).

    PubMed  CAS  Google Scholar 

  • Mahley, R. W., Weisgraber, K. H., Innerarity, T.: Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and non-atherogenic hyperlipidemia. Circulation Res. 35, 722–733 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Malinow, M. R., Maruffo, C. A., Perley, A.M.: Experimental atherosclerosis in squirrel monkeys (Saimiri sciurea). J. Path. Bact. 92, 491–510 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Malmros, H., Sternby, N.H.: Induction of atherosclerosis in dogs by a thiouracil-free semisynthetic diet containing cholesterol and hydrogenated coconut oil. Prog. Biochem. Pharmacol. 4, 482–487 (1968).

    CAS  Google Scholar 

  • Malmros, H., Wigand, G.: Atherosclerosis and deficiency of essential fatty acids. Lancet 11, 749–751 1959.

    Article  Google Scholar 

  • Mann, G. V., Andrus, S.B.: Xanthomatosis and atherosclerosis produced by diet in an adult rhesus monkey. J. Lab. clin. Med. 48, 533–550 (1956).

    PubMed  CAS  Google Scholar 

  • Mann, G.V., Andrus, S.B., Mcnally, A., Stare, F.J.: Experimental atherosclerosis in cebus monkeys. J. exp. Med. 98, 195–218 (1953).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Manning, P.J., Corwin, L.A., Jr., Middleton, C. C.: Familial hyperlipoproteinemia and thyroid dysfunction in beagles. Exp. molec. Path. 19, 378–388 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Marquie, G., Agid, R.: Influence de la race sur la sensibilité du Lapin à l’athérome expérimental. Experientia 28, 1068–1069 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Mccombs, H.L, Zook, B.C., Mcgandy, R.B.: Fine structure of spontaneous atherosclerosis of the aorta in the squirrel monkey. Amer. J. Path. 55, 235–252 (1969).

    PubMed  CAS  PubMed Central  Google Scholar 

  • Middleton, C. C., Clarkson, T.B., Lofland, H. B., Prichard, R. W.: Diet and atherosclerosis of squirrel monkeys. Arch. Path. 83, 145–153 (1967).

    PubMed  CAS  Google Scholar 

  • Moore, J. H.: The effect of the type of roughage in the diet on plasma cholesterol levels and aortic atherosis in rabbits. Brit. J. Nutr. 21, 207–215 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Morin, R. J., Bernick, S., Alfin-Slater, R. B.: Effects of essential fatty acid deficiency and supplementation on atheroma formation and regression. J. Atheroscler. Res. 4, 387–396 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Nam, S. C., Lee, W. M., Jarmolych, J., Lee, K. T., Thomas, W. A.: Rapid production of advanced atherosclerosis in swine by a combination of endothelial injury and cholesterol feeding. Exp. molec. Path. 18, 369–379 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Olson, R.E.: Atherosclerosis—a primary hepatic or vascular disorder? Perspect. Biol. Med. 2, 84–121 (1958).

    PubMed  CAS  Google Scholar 

  • Parwaresch, M.R., Mader, C., Hill, W., Wiswedel, K.: Ein Kombiniertes Verfahren zur Erzeugung von Arteriosklerose bei Kaninchen in Kurzzeitversuchen. Res. exp. Med. 160, 269–291 (1973).

    Article  CAS  Google Scholar 

  • Patek, P.R., Bernick, S., Ershoff, B.H., Wells, A.: Introduction of atherosclerosis by cholesterol feeding in the hypophysectomnized rat. Amer. J. Path. 42, 137–150 (1963).

    PubMed  CAS  PubMed Central  Google Scholar 

  • Prichard, R. W., Clarkson, T. B., Lofland, Jr., H. B., Goodman, H. O., Herndon, C. N., Net-Sky, M. G.: Studies on the atherosclerotic pigeon. J. Amer. med. Ass. 179, 49–52 (1962).

    Article  CAS  Google Scholar 

  • Pucak, G. J., Lehner, N. D. M., Clarkson, T. B., Bullock, B. C., Lofland, H. B.: Spider monkeys (Ateles sp.) as animal models for atherosclerosis research. Exp. molec. Path. 18, 32–49 (1973).

    CAS  Google Scholar 

  • Rinehart, J. F., Greenberg, L.D.: Pathogenesis of experimental arteriosclerosis in pyridoxine deficiency; with notes on similarities to human arteriosclerosis. Arch. Path. 51, 12–18 (1951).

    CAS  Google Scholar 

  • Roberts, D.C.K., West, C.E., Redgrave, T.G., Smith, J.B.: Plasma cholesterol concentration in normal and cholesterol-fed rabbits. Its variation and heritability. Atherosclerosis 19, 369–380 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Roberts, J. C. Jr., Straus, R.: Comparative atherosclerosis. New York: Hoeber Medical Division, Harper and Row (1965).

    Google Scholar 

  • Scebat, L., Renais, J., Lenegre, J.: Athérosclérose expérimentale du lapin. Etude preliminaire. Rev. Atherosclerose 3, 14–26 (1961).

    CAS  Google Scholar 

  • Skold, B. H., Getty, R.: Spontaneous atherosclerosis in swine. J. Amer. Vet. med. Ass. 139, 655–660 (1961).

    Google Scholar 

  • Srinivasan, S. R., Dalferes, E. R., Jr., Ruiz, H., Pargaonkar, P. S., Radhakrishnamurthy, B., Berenson, G. S.: Rapid serum lipoprotein changes in spider monkeys on short-term feeding of high cholesterol-high saturated fat diet. Proc. Soc. exp. Biol. (N.Y.) 141, 154–160 (1972).

    Article  CAS  Google Scholar 

  • Stamler, J., Pick, R., Katz, L.N.: Saturated and unsaturated fats. Effects on cholesterolemia and atherogenesis in chicks on high-cholesterol diets. Circulation Res. 7, 398–402 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Steiner, A., Kendall, F. E.: Atherosclerosis and arteriosclerosis in dogs following ingestion of cholesterol and thiouracil. Arch. Path. 42, 433–444 (1946).

    PubMed  CAS  Google Scholar 

  • Steiner, A., Kendall, F.E., Bevans, M.: Production of arteriosclerosis in dogs by cholesterol and thiouracil feeding. Amer. Heart J. 38, 34–42 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Strong, J. P., Mcgill, H.C. Jr.: Diet and experimental atherosclerosis in baboons. Amer. J. Path. 50, 669–690 (1967).

    PubMed  CAS  PubMed Central  Google Scholar 

  • Taylor, C. B., Cox, G. E., Manalo-Estrella, P., Southworth, J., Patton, D. E., Cathcart, C.: Atherosclerosis in rhesus monkeys. II. Arterial lesions associated with hypercholesteremia induced by dietary fat and cholesterol. Arch. Path. 74, 16–34 (1962).

    PubMed  CAS  Google Scholar 

  • Taylor, C. B., Manalo-Estrella, P., Cox, G. E.: Atherosclerosis in rhesus monkeys. V. Marked diet-induced hypercholesteremia with xanthomatosis and severe atherosclerosis. Arch. Path. 76, 239–249 (1963).

    PubMed  CAS  Google Scholar 

  • Vesselinovitch, D., Wissler, R. W., Fisher-Dzoga, K., Hughes, R., Dubien, L.: Regression of atherosclerosis in rabbits. 1. Treatment with low-fat diet, hyperoxia and hypolipidemic agents. Atherosclerosis 19, 259–275 (1974a).

    Article  CAS  Google Scholar 

  • Vesselinovitch, D., Getz, G.S., Hughes, R. H., Wissler, R. W.: Atherosclerosis in the rhesus monkey fed three food fats. Atherosclerosis 20, 303–321 (1974b).

    Article  CAS  Google Scholar 

  • Vles, R. O., Buller, J., Gottenbos, J. J., Thomasson, H. J.: Influence of type of dietary fat on cholesterol-induced atherosclerosis in the rabbit. J. Atheroscler. Res. 4, 170–183 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Wagner, W.D., Clarkson, T.B., Feldner, M.A., Prichard, R.W.: The development of pigeon strains with selected atherosclerosis characteristics. Exp. molec. Path. 19, 301–319 (1973).

    Google Scholar 

  • Wang, C.J., Schaefer, L.E., Drachman, S.R., Adlersberg, D.: Plasma lipid partition of the normal and cholesterol fed rabbit. J. Mt. Sinai Hosp. 21, 19–25 (1954).

    CAS  Google Scholar 

  • Wilson, R. B., Newberne, P. M., Conner, M. W.: An improved semisynthetic atherogenic diet for rabbits. Arch. Path. 96, 355–359 (1973).

    PubMed  CAS  Google Scholar 

  • Wissler, R. W., Eilert, M. L., Schroeder, M. A., Cohen, L.: Production of lipomatous and atheromatous arterial lesions in the albino rat. Arch. Path. 57, 333–351 (1954).

    CAS  Google Scholar 

  • Wissler, R. W., Frazier, L. E., Hughes, R. H., Rasmussen, R. A.: Atherogenesis in the cebus monkey. I. A comparison of three food fats under controlled dietary conditions. Arch. Path. 74, 312–322 (1962).

    PubMed  CAS  Google Scholar 

  • Wissler, R. W., Vesselinovitch, D.: Comparative pathogenic patterns in atherosclerosis. Advanc. Lipid Res. 6, 181–206 (1968).

    CAS  Google Scholar 

  • Wissler, R. W., Vesselinovitch, D.: Differences between human and animal atherosclerosis. In: Schettler, G., Weizel, A. (Eds.): Atherosclerosis III, pp. 319–325. Berlin-Heidelberg-New York: Springer 1974.

    Chapter  Google Scholar 

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  1. D. Kritchevsky
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  1. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, PA, 19104, USA

    David Kritchevsky Ph. D.

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Kritchevsky, D. (1975). Animal Models for Atherosclerosis Research. In: Kritchevsky, D. (eds) Hypolipidemic Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 41. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66190-7_6

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