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Hypolipidemic Agents pp 151–189Cite as

Mechanisms of Hyperlipidemia

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Abstract

Hyperlipidemia represents a spectrum of metabolic disorders, the manifestation of which includes an elevation of plasma cholesterol, triglyceride, or both above accepted normal limits. Primary lipid disorders are hereditary in nature, however, a number of plasma lipid disorders are secondary to an endocrine or nutritional imbalance or other disease processes. Although we allude to elevated cholesterol and/or triglycerides in plasma as criteria of defective lipid metabolism, a true understanding of the metabolic defects must reside in our understanding of the metabolism of the complex macromolecules which transport combinations of these lipids—i.e., the plasma lipoproteins. In the last decade we have learned a great deal about the synthesis, transport and catabolism of the various components of the lipoproteins. A completely integrated metabolic map is far from complete and in this review we will attempt to present a series of logical concepts which are supported by experimental data derived from experiments in man and other animals. At times we may indulge in speculation about possible mechanisms in areas where data are contradictory or missing. Unfortunately, few mechanisms seem fixed at the present time; instead they represent hypotheses based on limited data.

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Authors
  1. J. M. Felts
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  2. L. L. Rudel
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Editors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, PA, 19104, USA

    David Kritchevsky Ph. D.

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Felts, J.M., Rudel, L.L. (1975). Mechanisms of Hyperlipidemia. In: Kritchevsky, D. (eds) Hypolipidemic Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 41. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66190-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-66190-7_4

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