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Bile Acid Metabolism

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Book cover Hypolipidemic Agents

Abstract

Bile acids which are formed from cholesterol in the liver via a series of reactions initiated by 7α-hydroxylation of cholesterol (Danielsson and Einarsson, 1969) have several functions in the animal organism. Within the intestinal lumen the biliary bile acids facilitate formation of the micellar phase which appears to be obligatory for absorption of cholesterol and plays an essential role in the absorption of fat-soluble vitamins and hydrolysis products of triglycerides during fat digestion. Decrease of the intestinal bile acid concentration below a certain level (critical micellar concentration) prevents formation of the micellar phase, resulting in lipid malabsorption. Within the intestinal mucosa the bile acids seem to promote esterification of cholesterol and fatty acids and to inhibit cholesterol synthesis.

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  1. T. A. Miettinen
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  1. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, PA, 19104, USA

    David Kritchevsky Ph. D.

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Miettinen, T.A. (1975). Bile Acid Metabolism. In: Kritchevsky, D. (eds) Hypolipidemic Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 41. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66190-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-66190-7_3

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