Abstract
It is some 12 years since screening for teratogenicity became an important part of the toxicity tests on new substances, especially medicines. Yet tests in use until now are not generally regarded as satisfactory, and the degree of protection they afford to mankind is unknown.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Becker, B. A.: The statistics of teratology. Teratology 9, 261–262 (1974).
Brent, R. L.: Drug testing for teratogenicity: its implications, limitations and application to man. pp. 31–43 in Klingberg, M. A., Abramovici, A. and Chemke, J. (Eds.): Drugs and Fetal Development. New York: Plenum Press 1972.
Cahen, R L.: Evaluation of the teratogenicity of drugs. Clin. Pharmacol. Ther. 5, 480–514 (1964).
Healy, M. J. R.: Animal litters as experimental units. Appl. Statist. 21, 155–159 (1972).
Kalter, H: Choice of the number of sampling units in teratology. Teratology 9, 257–258 (1974).
Li, C. C: Introduction to Experimental Statistics. Ch. 30: Multiple measurements (pp. 403 to 415). New York: McGraw-Hill 1964.
Marriott, F. H. C: The Interpretation of Multiple Observations. New York: Academic Press 1974.
Palmer, A. K.: Problems associated with the screening of drugs for possible teratogenic activity. Ch. 2 (pp. 16–33) in Woollam, D. H. M. and Morris, G. M. (Eds.): Experimental Embryology and Teratology 1. London: Elek Science (1974 a).
Palmer, A. K.: Statistical analysis and choice of sample units. Teratology 10, 301–302 (1974 b).
Snedecor, G. W., Cochran, W. G.: Statistical Methods. 6th Ed., pp. 324–329. Ames, Iowa: Iowa State University Press 1967.
Sokal, R. R., Rohlf, F. J.: Biometry. Ch. 13: Assumptions of the analysis of variance (pp. 367–402). San Francisco: Freeman 1969.
Staples, R. E., Haseman, J. K.: Selection of appropriate experimental units in teratology. Teratology 9, 259–260 (1974).
Tuchmann-Duplessis, H.: Design and interpretation of teratogenic tests, pp.56–87 in Robson, J. M., Sullivan, F. M. and Smith, R. L. (Eds.): A Symposium on Embryopathie Activity of Drugs. London: Churchill 1965.
Tuchmann-Duplessis, H.: Teratogenic drug screening. Present procedures and requirements. Teratology 5, 271–285 (1972).
Weil, C. S.: Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction, teratogenesis or carcinogenesis. Fd. Cosmet. Toxicol. 8, 177–182 (1970).
Weil, C. S.: Choice of the number of sampling units in teratology. Teratology 10, 301 (1974).
W.H.O.: Principles for the testing of drugs for teratogenicity. Wld. Hlth Org. techn. Rep. Sen, 364 (1967).
Wilson, J. G.: Environment and Birth Defects. Ch. 9: Collection and interpretation of results (pp. 173–193). New York: Academic Press 1973.
Wilson, J. G.: Factors determining the teratogenicity of drugs, pp.205–217 in Elliott, H. W., Okun, R. and George, R. (Eds.): Ann. Rev. Pharmacol. 14. Palo Alto, Calif.: Annual Reviews Inc (1974).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Atkinson, R.M. (1975). Screening Medicines for Teratogenicity: Problems of Interpretation. In: Berry, C.L., Poswillo, D.E. (eds) Teratology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66172-3_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-66172-3_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66174-7
Online ISBN: 978-3-642-66172-3
eBook Packages: Springer Book Archive