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Teratological Investigations in Laboratory Primates: Why, When and How to Use Them

  • Chapter
Teratology

Abstract

The value of using laboratory animals to predict the teratogenicity of drugs or chemicals in man is not yet certain. Nonetheless a great deal of time and money is devoted annually to exercises of this kind. For reasons of economy and availability laboratory rodents and lagomorphs are the most favoured species for this work, and the susceptibility of these lower mammals to the teratogenic effects of a large number of compounds in common use is undisputed. A dilemma arises when attempts are made to assess whether evidence of teratogenicity in rats, mice, hamsters and rabbits has any special relevance to similar situations in man. Many attempts have been made to resolve these problems of extrapolation (WHO, 1967); it has been argued, for example, that on the basis of phylogenetic similarity, simian primates should be employed for the screening of compounds that may be teratogenic in man. While such reasoning may appear logical, there is little reliable data, from scientific investigations, to confirm or deny this suggestion (Tuchmann-Duplessis, 1972).

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Authors
  1. D. E. Poswillo
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  2. I. R. Phillips
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Editor information

Editors and Affiliations

  1. Guy’s Hospital Medical School, SEI 9RT, London, England

    C. L. Berry M. D., Ph. D. (Lond), M. R. C. Path. (University Reader in Pathology, Hon., Consultant Pathologist) (University Reader in Pathology, Hon., Consultant Pathologist)

  2. Guy’s Hospital, SEI 9RT, London, England

    C. L. Berry M. D., Ph. D. (Lond), M. R. C. Path. (University Reader in Pathology, Hon., Consultant Pathologist) (University Reader in Pathology, Hon., Consultant Pathologist)

  3. Royal College of Surgeons of England, Lincoln’s Inn Fields, London, England

    D. E. Poswillo D. Sc., F. D. S. R. C. S., F. D. S. R. C. S., M. R. C. Path. (Professor of Teratology, Consultant Oral and Maxillo-facial Surgeon) (Professor of Teratology, Consultant Oral and Maxillo-facial Surgeon)

  4. Queen Victoria Hospital, East Grinstead, England

    D. E. Poswillo D. Sc., F. D. S. R. C. S., F. D. S. R. C. S., M. R. C. Path. (Professor of Teratology, Consultant Oral and Maxillo-facial Surgeon) (Professor of Teratology, Consultant Oral and Maxillo-facial Surgeon)

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© 1975 Springer-Verlag Berlin · Heidelberg

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Poswillo, D.E., Phillips, I.R. (1975). Teratological Investigations in Laboratory Primates: Why, When and How to Use Them. In: Berry, C.L., Poswillo, D.E. (eds) Teratology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66172-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-66172-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66174-7

  • Online ISBN: 978-3-642-66172-3

  • eBook Packages: Springer Book Archive

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