Cell Death and Chemical Teratogenesis of the Heart
There are 20000 babies born with congenital heart defects each year in the United States (Overall, 1972). Of these defects 10% have a genetic etiology (Vernant etal., 1968; Doyle and Rutkowski, 1970; Emanuel, 1970; Campbell, 1973; Neill, 1973) and 10% may be of viral origin (Goerttler, 1970a), with rubella cardiopathies accounting for 2.8% (Jackson, 1968; Vernant etal., 1968). 80% of all congenital heart defects remain etiologically unexplained (Goerttler, 1970a). This vast majority of heart anomalies results from the interaction of many genes with environmental factors (Doyle and Rutkowski, 1970).
KeywordsChick Embryo Congenital Heart Defect Endocardial Cushion Atrioventricular Canal Heart Malformation
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