Interaction of Hemodynamics with the Cell Death Zones

Abstract

In the preceding chapter we saw how the changes in the form of different parts of the embryonic heart, especially of the bulbar complex, are accompanied by marked modifications of the intensity and localization of cell death suggesting its morphogenetic role. These parallel variations could be interpreted also as a simple time coincidence unless some proof of their mutual causal relationship were forthcoming. Of an equally great importance is the search for the causative agent of the described degenerations. Our previous training, experimental and reading experience led us to postulate the biomechanical action of heart hemodynamics as the potential cause of cell death in the bulbar and atrioventricular cushions. This postulation allows us to test two hypotheses in a common experimental situation: first the causal relationship between cell death and heart bulb morphogenesis, and second the causal relationships between cell death and hemodynamics.