Pankreas pp 265-516 | Cite as

Diagnostische Verfahren

Part of the Handbuch der inneren Medizin book series (INNEREN, volume 3 / 6)

Zusammenfassung

Das mit seinem größten Umfang unmittelbar vor der Wirbelsäule und dem Gefäßband in Höhe von L1—L2 tief im Mittelpunkt der Bauchhöhle gelegene Pankreas ist ein total retroperitoneales Organ von geringer Röntgendichte. Es ist schwierig zu untersuchen aufgrund seiner tiefen Lage, seinem zu geringen Absorptionsvermögen für Röntgenstrahlen sowie des Fehlens einer selektiven Sekretion eines Stoffes, der als Träger eines Kontrastmittels dienen könnte und die Durchführung einer venösen Parenchymatographie erlauben würde. Die Verbindung mehrerer Techniken miteinander macht es jedoch möglich, das Pankreas genau so gut zu untersuchen wie andere parenchymatöse Organe.

References

  1. Aakhus, T., Hofsli, M., Vestad, E.: Angiography in acute pancreatitis. Acta radiol. (Stockh.) 8, 119(1969).Google Scholar
  2. Abrams, R.M., Beranbaum, E.R., Beranbaum, S.L., Ngo, N.L.: Angiographic studies of benign and malignant cystadenoma of the pancreas. Radiology 89, 1028 (1967).PubMedGoogle Scholar
  3. Almén, T.: A steering device for selective angiography and some vascular and enzymatic reactions observed in its clinical application. Acta Radiol. (Stockh.) Suppl. 260 (1966).Google Scholar
  4. Baum, S., Roy, R., Finkelstein, A.K., Blakemore, W.S.: Clinical application of selective celiac and superior mesenteric arteriography. Radiology 84, 279 (1965).PubMedGoogle Scholar
  5. Bayindir, S.: Der Wert der kombinierten perkutanen transhepatischen Cholangiographie und Zöliakographie bei der Diagnostik des tumorbedingten Verschlußikterus. Fortschr. Röntgenstr. 109, 16(1968).Google Scholar
  6. Bennet, J., Chérigié, E., Caroli, J., Doyon,D., Economopoulos, P., Plessier, J., Stoopen, M.: La pancréatographie après stimulation par sécrétine intra-artérielle (A propos de 33 cas). Ann. Radiol. 10, 617(1967).PubMedGoogle Scholar
  7. Bieber, W.P., Albo, R.J.: Cystadenoma of the pancreas: Its arteriographic diagnosis. Radiology 80, 776(1963).PubMedGoogle Scholar
  8. Bismuth, H., Chaston, B., Matin, E., Hernandez, C., Hepp, I.: Les hémorragies digestives provenant des canaux pancréatiques (les hémo-wirsunguies). Arch. Mal. Appar. dig. 59, 735 (1970).Google Scholar
  9. Boijsen, E.: Selective pancreatic angiography. Brit. J. Radiol. 39, 481 (1966).PubMedGoogle Scholar
  10. Boijsen, E.: Angiographic diagnosis of pancreatic disease. T. Gastroent. 12, 219 (1969).PubMedGoogle Scholar
  11. Boijsen, E.: L’angiographie dans les pancréatopathies. Acta gastro-ent. belg. 33, 391 (1970).Google Scholar
  12. Boijsen, E.: Pancreatic angiography. In Abrams, H.L.: Angiography, 2nd ed., p. 953–981. Boston: Little, Brown and Company (Inc) 1971 a.Google Scholar
  13. Boijsen, E.: Superselective technique and pharmacoangiography in splanchnic arteriography. J. belg. Radiol. 54, 603 (1971b).PubMedGoogle Scholar
  14. Boijsen, E., Göthlin, J., Hallböök, T., Sandblom, Ph.: Preoperative angiographic diagnosis of bleeding aneurysms of abdominal visceral arteries. Radiology 93, 781 (1969).PubMedGoogle Scholar
  15. Boijsen, E., Olin, T.: Zöliakographie und Angiographie der Arteria mesenterica superior. In: Schinz, H.R., Glauner, R., Rüttimann, A. (Hrsg.): Ergebnisse der medizinischen Strahlenforschung, Bd. 1. p. 113–142. Stuttgart: G. Thieme Verlag 1964.Google Scholar
  16. Boijsen, E., Redman, H.: Effect of bradykinin on celiac and superior mesenteric angiography. Invest. Radiol. 1, 422 (1966).PubMedGoogle Scholar
  17. Boijsen, E., Redman, H.: Effect of epinephrine on celiac and superior mesenteric angiography. Invest. Radiol. 2, 184 (1967).PubMedGoogle Scholar
  18. Boijsen, E., Reuter, S.R.: Combined percutaneous transhepatic cholangiography and angiography in the evaluation of obstructive jaundice. Amer. J. Roentgenol. 99, 153 (1967).PubMedGoogle Scholar
  19. Boijsen, E., Samuelsson, L.: Angiographic diagnosis of tumors arising from the pancreatic islets. Acta Radiol. (Stockh.) 10, 161 (1969).Google Scholar
  20. Boijsen, E., Thylén, U.: Angiography in diagnosis. Clin. Gastroenterology 1, 85 (1972a).Google Scholar
  21. Boijsen, E., Tylén, U.: Vascular changes in chronic pancreatitis. Acta Radiol. (Stockh.) 12, 34 (1972b).Google Scholar
  22. Boijsen, E., Wallace, S., Kanter, I.E.: Angiography in tumours of the stomach. Acta Radiol. (Stockh.) 4, 306(1966)Google Scholar
  23. Bookstein, J.J.: Personal communication (1971).Google Scholar
  24. Bookstein, J.J., Reuter, S.R., Martel, W.: Angiographic evaluation of pancreatic carcinoma. Radiology 93, 757(1969).PubMedGoogle Scholar
  25. Böttger, E., Ochsenschläger, A., Asmar, F., Hasselbach, D.: Zum Aussagewert der hypotonen Duodenographie in der Diagnostik und Differentialdiagnostik der Duodenal-und Pankreaserkran-kungen. Fortschr. Röntgenstr. 116, 509 (1972).Google Scholar
  26. Buranasiri, S., Baum, S.: The significance of the venous phase of celiac and superior mesenteric arteriography in evaluating pancreatic carcinoma. Radiology 102, 11 (1972).PubMedGoogle Scholar
  27. Bücheler, E., Boldt, L., Frommhold, H., Käufer, C.: Die angiographische Diagnostik der Pankreas-tumoren und der Pankreatitis. Fortschr. Röntgenstr. 115, 726 (1971).Google Scholar
  28. Cen, M., Rosenbusch, G.: Zöliakographie mit Adrenalin (Möglichkeiten der Pharmakoangiographie in der Pankreasdiagnostik). Fortschr. Röntgenstr. 111, 82 (1969).Google Scholar
  29. Couinaud, C., Jouan, Prot, Chalut, Schneider: Hémo-lymphangiome de la tete du pancréas. Mem. Acad. Chir. 92, 152 (1966).PubMedGoogle Scholar
  30. Eaton, S.B., Fleischli, D.J., Pollard, J.J., Nebesar, R.A., Potsaid, M.S.: Comparison of current radiologic approaches to the diagnosis of pancreatic disease. New Engl. J. Med. 279, 389 (1968).PubMedGoogle Scholar
  31. Eisenberg, H.: Personal communication (1972).Google Scholar
  32. Fontaine, J.-L., Piétri, J., Babin, S.: De l’utilité de l’angiographie sélective d’urgence pour le diagnostic des hémopéritoines. Presse méd. 75, 655 (1967).PubMedGoogle Scholar
  33. Fredens, M., Egeblad, M., Holst-Nielsen, F.: The value of selective angiography in the diagnosis of tumours in pancreas and liver. Radiology 93, 765 (1969).PubMedGoogle Scholar
  34. Gambill, E.E.: Pancreatitis associated with pancreatic carcinoma: a study of 26 cases. Proc. Mayo Clin. 46, 174 (1971).PubMedGoogle Scholar
  35. Guien, C., Piétri, H., Sarles, H., Legre, J.: L’exploration tomographique des viscères abdominaux par pneumopéritoine et rétropneumopéritoine associés. J. Radiol. Électrol. 47, 321 (1966).PubMedGoogle Scholar
  36. Hepp, J., Hernandez, C., Moreaux, J., Bismuth, H.: L’arteriographie dans les affections chirurgicales du foie, du pancréas et de la rate. Paris: Masson et Cie. 1968.Google Scholar
  37. Hernandez, C., Ecarlat, B., Bismuth, V.J.: L’arterioportographie des affections pancréatique. J. Radiol. Électrol. 48, 327 (1967).PubMedGoogle Scholar
  38. Kadell, B.M., Riley, J.M.: Major arterial involvement by pancreatic pseudocysts. Amer. J. Roentgenol. 99, 632 (1967).PubMedGoogle Scholar
  39. Kahn, P.C., O’Halloran, J.F., Paul, R.E., Jr.: Improved portography by delayed postepinephrine celiac and mesenteric arteriography. Radiology 92, 86 (1969).PubMedGoogle Scholar
  40. Lechner, G., Pokieser, H.: Ergebnisse angiographischer Untersuchungen bei Pankreatitis. Fortschr. Röntgenstr. 114, 49(1971).Google Scholar
  41. Liotta, P., Jacquemet, P., Lamounette, J.: La technique de duodénographie hypotonique. Arch. Mal. Appar. dig. 46, 64 (1957).PubMedGoogle Scholar
  42. Lunderquist, A.: Angiography in carcinoma of the pancreas. Acta Radiol. (Stockh.) Suppl. 235 (1965).Google Scholar
  43. Marions, O., Wiechel, K.L.: Radiological investigation in jaundice. Läkartidning. 70, 951 (1973) (Swedish).Google Scholar
  44. Meaney, Th.F., Buonocore, E.: Arteriographic manifestations of pancreatic neoplasms. Amer. J. Roentgenol. 95, 720 (1965).PubMedGoogle Scholar
  45. Nebesar, R.A., Pollard, J.J.: Advances in abdominal angiography. Postgrad. Med. 37, 504 (1965).PubMedGoogle Scholar
  46. Nebesar, R.A., Pollard, J.J.: A critical evaluation of selective celiac and superior mesenteric angiography in the diagnosis of pancreatic diseases, particularly malignant tumors: facts and “artefacts”. Radiology 89, 1017 (1967).PubMedGoogle Scholar
  47. Oi, I., Kobayashi, S., Kondo, T.: Endoscopic pancreato-cholangiography. Endoscopy 2, 321 (1970).Google Scholar
  48. Olsson, O.: Angiography in tumors of the pancreas. In McLaren, J.N.: Modern trends in diagnostic radiology – 4. London: Butterworths 1970.Google Scholar
  49. Olsson, O.: Angiography in the diagnosis of duodenal lesions. II. Benign tumors, ulceration and inflammatory and vascular lesions. Acta Radiol. (Stockh.) 12, 164 (1972).Google Scholar
  50. Oscarson, J., Stormby, N., Sundgren, R.: Selective angiography in fine-needle aspiration cytodiag-nosis of gastric and pancreatic tumours. Acta Radiol. (Stockh.) 12, 737 (1972).Google Scholar
  51. Paul, R.E., Jr., Miller, H.H., Kahn, P.C., Callow, A.D., Edwards, T.L., Jr., Patterson, J.F.: Pancreatic angiography, with application of subselective angiography of the celiac and superior mesenteric artery of the diagnosis of carcinoma of the pancreas. New Engl. J. Med. 272, 283 (1965).PubMedGoogle Scholar
  52. Pokieser, H.: Angiographie der abdominellen Organe. In: Glauner, R., Rüttimann, A., Thurn, P., Viamonte, M., Vogler, E. (Hrsg.): Ergebnisse der medizinischen Radiologie, Bd. IV. p. 1–82. Stuttgart: G. Thieme Verlag 1972.Google Scholar
  53. Portsmann, W., Münster, W., Lucas, D., Romaniuk, P.-A.: Problematik der Pankreasarteriogra-phie. Radiol. Diagn. (Berlin) 12, 196 (1971).Google Scholar
  54. Reuter, S.R.: Superselective pancreatic angiography. Radiology 92, 74 (1969).PubMedGoogle Scholar
  55. Reuter, S.R., Redman, H.C., Joseph, R.R.: Angiographic findings in pancreatitis. Amer. J. Roentgenol. 107, 56 (1969).PubMedGoogle Scholar
  56. Rösch, J., Bret, J.: Arteriography of pancreas. Amer. J. Roentgenol. 94, 182 (1965).Google Scholar
  57. Rösch, J., Grollman, J.H., Jr.: Superselective arteriography in the diagnosis of abdominal pathology: technical considerations. Radiology 92, 1008 (1969).PubMedGoogle Scholar
  58. Rosenbusch, G., Cen, M., Diehlmann, W.: Indirekte Portographie mit Bradykinin bei Zustand nach Splenektomie (Möglichkeiten der Pharmakoangiographie). Fortschr. Röntgenstr. 111, 805 (1969).Google Scholar
  59. Rubinstein, Z.J., Bank, S., Marks, I.N., Psillos, C.P.: Hypotonic duodenography in chronic pancreatitis. Brit. J. Radiol. 44, 142 (1971).PubMedGoogle Scholar
  60. Sammons, B.P., Neal, M.P., Jr., Armstrong, R.H., Jr., Hager, H.G.: Ten years experience with celiac and upper abdominal superior mesenteric arteriography. Amer. J. Roentgenol. 101, 345 (1967).PubMedGoogle Scholar
  61. Sarles, H., Gerolami-Santandrea, A.: Chronic Pancreatitis. Clinics in Gastroenterology 1, 167 (1972).Google Scholar
  62. Seldinger, S.: Percutaneous transhepatic cholangiography. Acta Radiol. (Stockh.) Suppl. 253 (1966).Google Scholar
  63. Suzuki, T., Kawebe, K., Nakayasu, A., Takeda, H., Kobayashi, K., Kabuto, N., Honjo, L.: Selective arteriography in cancer of the pancreas at a resectable stage. Amer. J. Surg. 122, 402 (1971).PubMedGoogle Scholar
  64. Tavernier, J., Delorme, G., Lafitte, J., Tessier, J., Bellet, M.: Apports de l’angiographie coeliaque et mésentérique a la radiographie pancréatique. J. Radiol. Électrol. 50, 867 (1969).PubMedGoogle Scholar
  65. Taylor, D.A., Macken, K.L., Fiore, A.S.: Angiographie visualization of the secretin-stimulated pancreas. Radiology 87, 525 (1966).PubMedGoogle Scholar
  66. Trapnell, J.: The natural history and management of acute pancreatitis. Clinics in Gastroenterology 1, 147(1972).Google Scholar
  67. Tylén, U.: Angiographic in inflammatory and malignant diseases of the pancreas. Diss. Studentliteratur, Lund (1972).Google Scholar
  68. Tylén, U.: The accuracy of angiography in the diagnosis of carcinoma of the pancreas. Acta Radiol. (Stockh.) 14, 447 (1973 a).Google Scholar
  69. Tylén, U.: Angiographic differentiation between inflammatory disease and carcinoma of the pancreas. Acta Radiol. (Stockh.) 14, 257 (1973 b).Google Scholar
  70. Tylén, U., Arnesjö, B.: Angiographic diagnosis of inflammatory disease of the pancreas. Acta Radiol. (Stockh.) 14, 215 (1973).Google Scholar
  71. Tylén, U., Dencker, H.: Roentgenologic diagnosis of pancreatic abscess. Acta Radiol. (Stockh.) 14, 9 (1973).Google Scholar
  72. Udén, R.: Effect of secretin in celiac and superior mesenteric angiography. Acta Radiol. (Stockh.) 8, 497 (1969).Google Scholar
  73. van Voorthuisen, A.E.: Disappointing results in angiographic exploration of the pancreas. J. belg. Radiol. 54, 621 (1971).PubMedGoogle Scholar
  74. Weiss, H.D., Anacker, H., Wiesner, W.: Die Technik der Duodenoskopie mit retrograder Pancrea-tiko-und Cholangiographie. Fortschr. Röntgenstr. 116, 517 (1972).Google Scholar
  75. Wenz, W.: Die Angiographie in der chirurgischen Diagnostik der Bauchorgane. Arch. klin. Chir. 222, 127 (1968).Google Scholar
  76. Wiechel, K.L.: Transhepatic cholangiography. Acta chir. scand. Suppl. 330 (1964).Google Scholar

Liteatur

  1. Anacker, H.: Die pathologischen Veränderungen des Pankreasgangsystems im Röntgenbild. Röfo 96, 455–470(1962).Google Scholar
  2. Becker, V.: Bauchspeicheldrüse, S. 100. Berlin-Heidelberg-New York: Springer-Verlag 1973.Google Scholar
  3. Belohlavek, D.: Laparoskopische Pankreoskopie. VI. Kongreß der Dtsch. Ges. f. Endoskopie, 1973.Google Scholar
  4. Classen, M., Koch, H., Frühmorgen, P., Grabner, W., Demling, L.: Results of Retrograde Pancreaticography. Acta Gastroent. Japon. 7, 131–133 (1972).Google Scholar
  5. Classen, M., Hellwig, H., Rösch, W.: Anatomy of the Pancreatic Duct. A Duodenoscopic-Radio-logical Study. Endoscopy 5, 14–17 (1973).Google Scholar
  6. Cotton, P.B.: Cannulation of the papilla of Vater by endoscopy and retrograde cholangiopancreatography (ERCP). Gut 13, 1014–1025 (1972).PubMedGoogle Scholar
  7. Kasugai, T., Kuno, N., Aoki, L., et al.: Fiberduodenoscopy: analyses of 353 examinations. Gastrointest. Endosc. 18, 9–16 (1971).PubMedGoogle Scholar
  8. Koch, H., Kozu, T., Bauerle, H., Classen, M., Demling, L.: Technik der Duodensokopie: Duodenoskopie: Fortschr. der Endoskopie 3. Stuttgart-New York: Sehattauer 1972.Google Scholar
  9. Koch, H., Classen, M.: Radiologisch-endoskopische Diagnostik der Pankreatitis. Röntgenberichte 2, 31 (1973).Google Scholar
  10. Look, D., Henning, H., Lüders, C.J.: Darstellung und Biopsie des Pankreaskopfes bei der Laparoskopie. Z. Gastroent. 10, 209 (1972).Google Scholar
  11. Meyer-Burg, J.: Die laparoskopische Inspektion, Palpation und Biopsie des Pankreas. Leber Magen Darm 2, 93 (1972).PubMedGoogle Scholar
  12. Ogoshi, K., Niwa, M., Hara, Y., Nebel, O.T.: Endoscopic pancreatocholangiography in the evaluation of pancreatic and biliary disease. Gastroenterology 64, 210–216 (1973).PubMedGoogle Scholar
  13. Oi, I.: Fiberduodenoscopy and endoscopic pancreatocholangiography. Gastrointest. Endose. 17, 59–62 (1970).Google Scholar
  14. Ottenjann, R.: Persönliche Mitteilung.Google Scholar
  15. Sterling, J. A.: The common channel for bile and pancreatic ducts. Surg. Gynec. Obstet. 98, 420–424 (1954).PubMedGoogle Scholar
  16. Strauch, M., Lux, G., Ottenjann, R.: Infragastric Pancreoscopy. Endoscopy 5, 30, (1973).Google Scholar
  17. Vennes, J.A., Silvis, S.E.: Endoscopic visualization of bile and pancreatic ducts. Gastrointest. Endose.Google Scholar

References

  1. Asnaes, S., Johansen, A.: Duodenal exfoliative cytology. Acta path, microbiol. scand. Suppl. 212, 11–14(1970).Google Scholar
  2. Bowden, L., Papanicolaou, G.N.: The diagnosis of pancreatic cancer by cytologic study of duodenal secretion. Acta Un. int. Cancer 16, 398–404 (1960). (Quoted by Olsen, 1971.)Google Scholar
  3. Butler, E.B.: Pancreatic cytology, Clinics in Gastroenterology 1, 53–60 (1972).Google Scholar
  4. Goldstein, H., Ventzke, L.E.: Value of exfoliative cytology in pancreatic carcinoma. Gut 9, 316–318 (1968).PubMedGoogle Scholar
  5. Henning, N., Witte, S., Bressel, D.: The cytological diagnosis of tumours of the upper gastrointestinal tract (esophagus, stomach and duodenum). Acta Cytologica 8, 121–128 (1964).PubMedGoogle Scholar
  6. Henning, N., Witte, S.: Atlas of Gastrointestinal Diagnosis, first English edition, p. 20–25. London: Pitman Medical and Scientific Publishing 1970.Google Scholar
  7. Ishii, K., Tadashi, T., Nakamura, K.: Exocrine pancreatic function in Chronic disease of the pancreas. Advance Abstracts, 4th World Congress of Gastroenterology. The Danish Gastroenterological Association, Copenhagen. (Quoted by Olsen, 1971.)Google Scholar
  8. Lemon, H.M., Byrnes, W.W.: Cancer of the biliary tract and pancreas. Diagnosis from cytology of duodenal aspiration. J. Amer. med. Ass. 141, 254–257 (1949).Google Scholar
  9. Nieburgs, H.E., Dreiling, D.A., Rubio, C., Reisman, H.: The morphology of cells in duodenal drainage smears: histological origin and pathological significance. Amer. J. dig. Dis. 7, 489–504 (1962).PubMedGoogle Scholar
  10. Olsen, J.H.: Duodenal exfoliative cytology. Diagnosis of cancer of duodenum, pancreas and biliary tract by exfoliative cytology. Scand. J. Gastroenterology 6, Suppl. 9: 105–109 (1971).Google Scholar
  11. Raskin, H.F., Wenger, J., Sklar, M., Pleticka, S., Yarema, W.: The diagnosis of cancer of the pancreas, biliary tract and duodenum by combined cytological and secretory methods. I. Exfoliative cytology and a description of a rapid method of duodenal intubation. Gastroenterology 34, 996–1008 (1958).PubMedGoogle Scholar
  12. Raskin, H.F., Kirsner, J.B., Palmer, W.L., Pleticka, S.: The clinical value of the negative gastrointestinal exfoliative cytologic examination in cancer suspects. Gastroenterology 42, 266–274 (1962).PubMedGoogle Scholar
  13. Sarles, H., Sarles, J.-C, Camatte, R., Muratore, R., Gaini, M., Guien, C., Pastor, J., Le Roy, F.: Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis and chronic pancreatitis. Gut 6, 545–559 (1965).PubMedGoogle Scholar
  14. Wenger, J., Raskin, H.F.: The diagnosis of cancer of the pancreas, biliary tract and duodenum by combined cytological and secretory methods. II. The secretin test. Gastroenterology 34, 1009–1017(1958).PubMedGoogle Scholar

Literatur

  1. Adlercreutz, H., Salmi, H.J., Soininen, K., Härkönen, M.: Determination of α-amylase in serum and urine of subjects with a low bicarbonate concentration in the duodenal aspirate after secretin stimulation. Clin. chim. Acta 43, 187–193 (1973).PubMedGoogle Scholar
  2. Ambromovage, A.M., Howard, J.M., Pairent, F.W.: The twenty-four hour excretion of amylase and lipase in the urine. Ann. Surg. 167, 539–546 (1968).PubMedGoogle Scholar
  3. Anderer, F.A.: Strukturuntersuchungen am Kallikrein-Inaktivator aus Rinderlunge. IL Bestimmung der Aminosäuresequenz. Z. Naturforsch. 20b, 462–472 (1965).Google Scholar
  4. Anderer, F.A., Hörnle, S.: Strukturuntersuchungen am Kallikrein-Inaktivator aus Rinderlunge. I. Molekulargewicht, Endgruppenanalyse und Aminosäure-Zusammensetzung. Z. Naturforsch. 20b, 457–462 (1965).Google Scholar
  5. Anderer, F.A., Hörnle, S.: The disulfide linkages in kallikrein inactivator of bovine lung. J. biol. Chem. 241, 1568–1572 (1966).PubMedGoogle Scholar
  6. Aw, S.E., Hobbs, J.R., Wootton, I.D.P.: Urinary isoamylases in the diagnosis of chronic pancreatitis. Gut 8, 402–407(1967).PubMedGoogle Scholar
  7. Babson, A.L., Kleinman, N.M., Megraw, R.E.: A new substrate for serum amylase determination. Clin. Chem. 14, 802–803 (1968).Google Scholar
  8. Babson, A.L., Tenney, S.A., Megraw, R.E.: New amylase substrate and assay procedure. Clin. Chem. 16, 39–43 (1970).PubMedGoogle Scholar
  9. Bang, H.O.: A simple method for determination of lipase (esterase) in pancreatic juice. Scand. J. clin. Lab. Invest. 17, 25–30 (1965).PubMedGoogle Scholar
  10. Barrowman, J. A., Borgström, B.: Specificity of certain methods for the determination of pancreatic lipase. Gastroenterology 55, 601–607 (1968).PubMedGoogle Scholar
  11. Bergmeyer, H.U.: Standardization of the reaction temperature for the determination of enzyme activity. Z. klin. Chem. klin. Biochem. 11, 39–45 (1973).PubMedGoogle Scholar
  12. Bergmeyer, H.U. (Hrsg.): Methoden der enzymatischen Analyse. 3. Auflage. Weinheim: Verlag Chemie 1974.Google Scholar
  13. Berk, J.B., Searcy, R.L.: Isoenzymes of serum amylase in man. Gastroenterology 48, 651–653 (1965).PubMedGoogle Scholar
  14. Berk, J.E., Hayashi, S., Searcy, R.L., Hightower, N.C.: Differentiation of parotid and pancreatic amylase in human serum. Amer. J. digest. Dis. 11, 695–701(1966).Google Scholar
  15. Berk, J.E., Kizu, H., Take, S., Fridhandler, L.: Macroamylasemia: Clinical and laboratory features. Amer. J. Gastroenterol. 53, 211–222 (1970a).Google Scholar
  16. Berk, J.E., Kizu, H., Take, S., Fridhandler, L.: Macroamylasemia: Serum and urine amylase characteristics. Amer. J. Gastroenterol. 53, 223–229 (1970b).Google Scholar
  17. Bernfeld, P.: Enzymes of starch degradation and synthesis. Adv. Enzymol. 12, 379 (1951).Google Scholar
  18. Blainey, J.D., Northam, B.E.: Amylase excretion by the human kidney. Clin. Sci. 32, 377–383 (1967).PubMedGoogle Scholar
  19. Borgström, B.: Effect of tauro-cholic acid on the pH/activity curve of rat pancreatic lipase. Biochim. biophys. Acta 13, 149–150 (1954a).PubMedGoogle Scholar
  20. Borgström, B.: On the mechanism of pancreatic lipolysis of glycerides. Biochim. biophys. Acta 13, 491–504 (1954b).PubMedGoogle Scholar
  21. Borgström, B.: Determination of pancreatic lipase in human small intestinal content. Scand. J. clin. Lab. Invest. 9, 226–228 (1957).PubMedGoogle Scholar
  22. Borgström, B.: Influence of bile salt, pH, and time on the action of pancreatic lipase; physiological implications. J. Lipid Res. 5, 522–531 (1964).Google Scholar
  23. Brockerhoff, H.: On the function of bile salts and proteins as cofactors of lipase. J. biol. Chem. 246, 5828–5831 (1971).PubMedGoogle Scholar
  24. Brown, J.R., Yamasaki, M., Neurath, H.: A new form of bovine pancreatic procarboxypeptidase A. Biochemistry 2, 877–886 (1963).PubMedGoogle Scholar
  25. Brown, J.R., Hartley, B.S.: Location of disulphide bridges by diagonal paper electrophoresis. Biochem. J. 101, 214–228 (1966).PubMedGoogle Scholar
  26. Budd, J.J., Walter, K.E., Harris, M.L., Knight, W.A.: Urine diastase in the evaluation of pancreatic disease. Gastroenterology 36, 333–353 (1959).PubMedGoogle Scholar
  27. Bunch, L.D., Emerson, R.L.: Serum lipase determination. Four-hour technique with olive oil substrate. Clin. Chem. 2, 75–82 (1956).PubMedGoogle Scholar
  28. Burton, P., Hammond, E.M., Harper, A.A., Howat, H.T., Scott, J.E., Varley, H.: Serum amylase and serum lipase levels in man after administration of secretin and pancreozymin. Gut 1, 125–139 (1960).PubMedGoogle Scholar
  29. Calkins, W.G.: A study of urinary amylase excretion in normal persons. Amer. J. Gastroenterol. 46, 407–412(1966).Google Scholar
  30. Ceska, M.K., Birath, K., Brown, B.: A new and rapid method for the clinical determination of α-amylase activities in human serum and urine. Optimal conditions. Clin. chim. Acta 26, 437–444(1969).Google Scholar
  31. Cherry, I.S., Crandall, L.A.: The specificity of pancreatic lipase: Its appearance in the blood after pancreatic injury. Amer. J. Physiol. 100, 266–273 (1932).Google Scholar
  32. Close, J.R., Street, H.V.: An ultra-micro method for determination of amylase activity in blood serum. Clin. chim. Acta 3, 476–479 (1958).PubMedGoogle Scholar
  33. Cohen, S.G., Milovanovic, A., Schultz, R.M., Weinstein, S.Y.: On the active site of α-chymotryp-sin. J. biol. Chem. 244, 2664–2674 (1969).PubMedGoogle Scholar
  34. Cox, D.J., Wintersberger, E., Neurath, H.: Bovine pancreatic procarboxypeptidase B. II. Mechanism of activation. Biochemistry 1, 1078–1082 (1962).PubMedGoogle Scholar
  35. Dahlqvist, A.: A method for the determination of amylase in intestinal content. Scand. J. clin. Lab. Invest. 14, 145–151 (1962).PubMedGoogle Scholar
  36. Delcourt, A., Wettendorff, P.: La clearance rénale de l’amylase a l’état normal et au cours d’affections pancréatiques. Acta clin. Belg. 19, 265–270 (1964).PubMedGoogle Scholar
  37. Desnuelle, P., Reboud, J.P., Ben Abdeljlil, A.: Influence of the composition of the diet on the enzyme content of rat pancreas. In: De Reuck, A.V.S., Cameron, M.P. (Eds.): The exocrine pancreas, S. 90–107. London: Churchill 1962.Google Scholar
  38. Dixon, M., Webb, E.C.: Enzymes. London: Longmans 1958.Google Scholar
  39. Dreiling, D.A., Janowitz, H.D., Josephberg, L.J.: Serum isoamylases. An electrophoretic study of the blood amylase and the patterns observed in pancreatic disease. Ann. int. Med. 58, 235–244 (1963).Google Scholar
  40. Empfehlungen der Deutschen Gesellschaft für Klinische Chemie: Standardisierung von Methoden zur Bestimmung von Enzymaktivitäten in biologischen Flüssigkeiten. Z. klin. Chem. 8, 658–659 (1970).Google Scholar
  41. Empfehlungen der Enzymkommission der Internationalen Union für Biochemie. London: Pergamon Press 1961.Google Scholar
  42. Enzyme Nomenclature. Amsterdam: Elsevier Scientific Publ. Comp. 1973.Google Scholar
  43. Erlanger, B.F., Kokowsky, N., Cohen, W.: The preparation and properties of two new chromogenic substrates of trypsin. Arch. Biochem. 95, 271–278 (1961).PubMedGoogle Scholar
  44. Erlanger, B.F., Edel, F., Cooper, A.G.: The action of chymotrypsin on two new chromogenic substrates. Arch. Biochem. Biophys. 115, 206–210 (1966).PubMedGoogle Scholar
  45. Erlanson, C., Borgström, B.: Tributyrine as a substrate for determination of lipase activity of pancreatic juice and small intestinal content. Scand. J. Gastroent. 5, 293–295 (1970).PubMedGoogle Scholar
  46. Figarella, C., Clemente, F., Guy, O.: On zymogens of human pancreatic juice. FEBS Letters 3, 351–353 (1969).PubMedGoogle Scholar
  47. Figarella, C., Ribeiro, T.: The assay of human pancreatic phospholipase A in pancreatic juice and duodenal contents. Scand. J. Gastroent. 6, 133–137 (1971).PubMedGoogle Scholar
  48. Figarella, C., Negri, G.A., Sarles, H.: Presence of colipase in a congenital pancreatic lipase deficiency. Biochim. biophys. Acta 280, 205–210 (1972).PubMedGoogle Scholar
  49. Folk, J.E.: A new pancreatic carboxypeptidase. J. Amer. Chem. Soc. 78, 3541–3542 (1956).Google Scholar
  50. Folk, J.E., Piez, K.A., Carroll, W.R., Gladner, J.A.: Carboxypeptidase B. J. biol. Chem. 235, 2272–2277(1960).PubMedGoogle Scholar
  51. Folk, J.E., Schirmer, E.W.: Chymotrypsin C. J. biol. Chem. 240, 181–192 (1965).PubMedGoogle Scholar
  52. Fraser, G.P., Fenton, J.C.B.: A stable starch preparation for amylase determinations. J. clin. Path. 21, 764–766(1968).PubMedGoogle Scholar
  53. Fredrickson, D.S., Ono, K., Davis, L.L.: Lipolytic activity of post-heparin plasma in hyperglyceridemia. J. Lipid Res. 4, 24–33 (1963).PubMedGoogle Scholar
  54. Fridhandler, L., Berk, J.E., Ueda, M.: Macroamylasemia: Rapid detection method. Clin. Chem. 17, 423–426(1971).PubMedGoogle Scholar
  55. Fried, R., Hoeflmayr, J.: Die diagnostische Bedeutung der Lipase und ihre routinemäßige fotometrische Bestimmung. Therapie Gegenw. 1969, 1788–1798.Google Scholar
  56. Fried, R., Hoeflmayr, J.: Die Bestimmung der Lipaseaktivität unter Verwendung von Olivenöl als Substrat in neuer Form. Z. klin. Chem. klin. Biochem. 11, 189–192 (1973).PubMedGoogle Scholar
  57. Fritsch, W.-P., Rick, W.: Postheparin-Lipase. In: Bergmeyer, H.U. (Hrsg.), Methoden der enzymatischen Analyse. 3. Aufl., S. 854–861. Weinheim: Verlag Chemie 1974.Google Scholar
  58. Gambill, E.E., Mason, H.L.: Urinary amylase excretion per hour in 100 individuals without gastrointestinal disease or renal insufficiency J. Lab. clin. Med. 63, 173–176 (1964a).PubMedGoogle Scholar
  59. Gambill, E.E., Mason, H.L.: Urinary amylase vs serum amylase in patients with pancreatic carcinoma. J. Amer. med. Ass. 188, 824–826 (1964b).Google Scholar
  60. Gertler, A., Hofmann, T.: Acetyl-L-alanyl-L-alanyl-L-alanine methyl ester: a new highly specific elastase substrate. Cañad. J. Biochem. 48, 384–386 (1970).Google Scholar
  61. Goebell, H.: Diagnostische Möglichkeiten mit der Bestimmung von Amylase und Lipase in Körperflüssigkeiten. Internist 11, 117–122 (1970).PubMedGoogle Scholar
  62. Goebell, H., Bode, Ch., Lemberg, G.: Lipase und Amylase im Serum in der Pankreatitisdiagnostik. Erfahrungen mit einer neuen Lipasebestimmung. Verh. Dtsch. Ges. inn. Med. 74, 233–235. München: Verlag J.F. Bergmann 1968.PubMedGoogle Scholar
  63. Hadorn, B., Silberberg, V.L.: Demonstration of two forms of human pancreatic carboxypeptidase A. Biochim. biophys. Acta 151, 702–705 (1968).PubMedGoogle Scholar
  64. Härtel, A., Banauch, D., Helger, R.: Ein Suchtest für Lipase im Serum. Z. klin. Chem. klin. Biochem. 9, 396–397 (1971).PubMedGoogle Scholar
  65. Hartley, B.S.: Amino-acid sequence of bovine chymotrypsinogen A. Nature 201, 1284–1287 (1964).PubMedGoogle Scholar
  66. Hayashi, Y., Lawson, W.B.: Stereochemistry of the active site of α-chymotrypsin. J. biol. Chem. 244, 4158–4167(1969).PubMedGoogle Scholar
  67. Helger, R., Lang, H.: Internationale Einheiten bei der Bestimmung der α-Amylase. Ärztl. Laboratorium 11, 120–123 (1965).Google Scholar
  68. Henry, R.J.: Pancreatitis-lipase. In: Seligson, D. (Ed.), Standard methods in clinical chemistry 2, S. 86–90. New York: Academic Press 1958.Google Scholar
  69. Henry, R.J., Sobel, C., Berkman, S.: On the determination of “pancreatitis-lipase” in serum. Clin. Chem. 3, 77–89 (1957).PubMedGoogle Scholar
  70. Hostettler, F., Borel, E., Deuel, H.: Über die Reduktion der 3,5-Dinitrosalicylsäure durch Zucker. Helv. chim. Acta 34, 2132–2139 (1951).Google Scholar
  71. Hsiu, J., Fischer, E.H., Stein, E.A.: Alpha-amylases as calcium-metalloenzymes. IL Calcium and the catalytic activity. Biochemistry 3, 61–64 (1964).PubMedGoogle Scholar
  72. Hummel, B.C.W.: A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. Canad. J. Biochem. Physiol. 37, 1393–1399 (1959).PubMedGoogle Scholar
  73. Jacks, T.J., Kircher, H.W.: Fluorometric assay for the hydrolytic activity of lipase using fatty acyl esters of 4-methylumbelliferone. Analyt. Biochem. 21, 279–285 (1967).PubMedGoogle Scholar
  74. Jacobsen, C.F., Leonis, J., Linderstrom-Lang, K., Ottesen, M.: The pH-stat and its use in biochemistry. In: Glick, D. (Ed.), Methods of biochemical analysis 4, S. 171–210. New York: Interscience Publ. 1957.Google Scholar
  75. Kassell, B., Laskowski, M.: Basic trypsin inhibitor of bovine pancreas. Biochem. Biophys. Res. Comm. 20, 463–468 (1965).PubMedGoogle Scholar
  76. Kazal, L.A., Spicer, D.S., Brahinsky, R.A.: Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas. J. Amer. Chem. Soc. 70, 3034–3040 (1948).Google Scholar
  77. Keil, B., Pruzik, Z., Sorm, F.: Disulphide bridges and a suggested structure of chymotrypsinogen. Biochim. biophys. Acta 78, 559–561 (1963).PubMedGoogle Scholar
  78. Keller, P.J., Allan, B.J.: The protein composition of human pancreatic juice. J. biol. Chem. 242, 281–287 (1967).PubMedGoogle Scholar
  79. Keller, P.J.: Pancreatic proteolytic enzymes. In: Code, Ch.F. (Ed.), Handbook of Physiology, Section 6, Vol. V. S. 2605–2628. Washington: Amer. Physiol. Soc. 1968.Google Scholar
  80. Kézdy, F.J., Kaiser, E.T.: Principles of active site titration of proteolytic enzymes. In: Perlmann, G.E., Lorand, L. (Eds.), Methods in Enzymology, Vol. 19. S. 3–20. New York: Academic Press 1970.Google Scholar
  81. Kirshen, R., Gambill, E.E., Mason, H.L.: Comparison of urinary and serum amylase values following pancreatic stimulation in patients with and without pancreatic disease. Gastroenterology 48, 579–583(1965).PubMedGoogle Scholar
  82. Klein, B., Foreman, J.A., Searcy, R.L.: New chromogenic substrate for determination of serum amylase activity. Clin. Chem. 16, 32–38 (1970).PubMedGoogle Scholar
  83. Kraut, H., Bhargava, N.: Versuche zur Isolierung des Kallikrein-Inaktivators, V. Isolierung eines Kallikrein-Inaktivators aus Rinderlunge und seine Identifizierung mit dem Inaktivator aus Rinder-parotis. Z. physiol. Chem. 338, 231–237 (1964).Google Scholar
  84. Krisch, K.: Eigenschaften und Substratspezifität einer Esterase aus Schweinelebermikrosomen. Biochem. Z. 337, 546–573 (1963).PubMedGoogle Scholar
  85. Krisch, K.: Carboxylic ester hydrolases. In: Boyer, P.D. (Ed.), The Enzymes. 3. Aufl., Vol. V, S. 43–69. New York: Academic Press 1971.Google Scholar
  86. Kunitz, M., Northrop, J.H.: Isolation from beef pancreas of crystalline trypsinogen, trypsin, a trypsin inhibitor, and an inhibitor-trypsin compound. J. Gen. Physiol. 19, 991–1007 (1936).PubMedGoogle Scholar
  87. De La Lande, F.A., Boettcher, B.: Electrophoretic examination of human serum amylase isoenzymes. Enzymologia 37, 335–342 (1969).PubMedGoogle Scholar
  88. Lauber, K.: Amylasebestimmung. Z. klin. Chem. klin. Biochem. 7, 38–41 (1969).PubMedGoogle Scholar
  89. Levitt, M.D., Rapoport, M., Cooperband, S.R.: The renal clearance of amylase in renal insufficiency, acute pancreatitis and macroamylasemia. Ann. int. Med. 71, 919–925 (1969).PubMedGoogle Scholar
  90. Levitt, M.D., Duane, W.C., Cooperband, S.R.: Study of macroamylase complexes. J. Lab. clin. Med. 80, 414–422(1972).PubMedGoogle Scholar
  91. Lorentz, K., Zander, A., Adlung, J.: Untersuchungen zur amyloklastischen α-Amylase-Bestim-mung. Z. klin. Chem. klin. Biochem. 7, 241–249 (1969).PubMedGoogle Scholar
  92. Lundh, G.: Determination of trypsin and chymotrypsin in human intestinal content. Scand. J. clin. Lab. Invest. 9, 229–232 (1957).PubMedGoogle Scholar
  93. Mahadevan, S., Dillard, C.J., Tappel, A.L.: A modified colorimetric micro method for long-chain fatty acids and its application for assay of lipolytic enzymes. Analyt. Biochem. 27, 387–396 (1969).PubMedGoogle Scholar
  94. Malacinski, G.M.: Determination of mammalian serum α-amylase levels with a radioactive-substrate assay. Amer. J. clin. Path. 56, 623–626 (1971).Google Scholar
  95. Marchis-Mouren, G., Sarda, L., Desnuelle, P.: Purification of hog pancreatic lipase. Arch. Biochem. Biophys. 83, 309–319 (1959).PubMedGoogle Scholar
  96. Marsh, W.H., Fitzgerald, P.J.: Pancreas acinar cell differentiation. IV. Assay of nanogram levels of chymotrypsin by radioactively labeled synthetic substrate. Analyt. Biochem. 40, 72–79 (1971).PubMedGoogle Scholar
  97. Massion, Ch.G., Seligson, D.: Serum lipase. A rapid photometric method. Amer. J. clin. Path. 48, 307–313(1967).Google Scholar
  98. Mattson, F.H., Volpenhein, R.A.: Relative rates of hydrolysis by rat pancreatic lipase of esters of C2-C18 fatty acids with C1-C18 primary n-alcohols. J. Lipid Res. 10, 271–276 (1969).PubMedGoogle Scholar
  99. Mattson, F.H., Volpenhein, R.A.: Hydrolysis of fully esterified alcohols containing from one to eight hydroxyl groups by the lipolytic enzymes of rat pancreatic juice. J. Lipid Res. 13, 325–328 (1972).PubMedGoogle Scholar
  100. Maylié, M.F., Charles, M., Gaché, C., Desnuelle, P.: Isolation and partial identification of a pancreatic colipase. Biochim. biophys. Acta 229, 286–289 (1971).PubMedGoogle Scholar
  101. McDonald, R.P., LeFave, R.O.: Serum lipase determination with an olive oil substrate using a three-hour incubation period. Clin. Chem. 8, 509–519 (1962).Google Scholar
  102. Mettes, S., Rogols, S.: Serum amylases, isoenzymes, and pancreatitis. I. Effect of substrate variation. Clin. Chem. 14, 1176–1184 (1968).Google Scholar
  103. Melius, P., Doster, M.S.: Studies on 4-methylumbelliferone caprylate as a substrate for hog pancreatic lipase. Analyt. Biochem. 37, 395–401 (1970).PubMedGoogle Scholar
  104. Meyer, K.H., Fischer, E.H., Bernfeld, P.: Sur les enzymes amylolytiques. (I) L’isolement de l’α-amylase de pancréas. Helv. chim. Acta 30, 64–78 (1947).PubMedGoogle Scholar
  105. Meyer-Bertenrath, J.G., Kaffarnik, H.: Eine einfache Methode zur Bestimmung von Lipase-Aktivitäten. Hoppe-Seyler’s Z. physiol. Chem. 349, 1071–1072 (1968).PubMedGoogle Scholar
  106. Mulhausen, R., Brown, D.C., Onstad, G.: Renal clearance of amylase during pancreatitis. Metabolism: Clin. Exp. 18, 669–674 (1969).Google Scholar
  107. Näher, G.: Lipase. In: Bergmeyer, H.U. (Hrsg.), Methoden der enzymatischen Analyse, 2. Aufl., S. 781–786. Weinheim: Verlag Chemie 1970.Google Scholar
  108. Nagel,W., Willig, F., Peschke, W., Schmidt, F.H.: Über die Bestimmung von Trypsin und Chymotrypsin mit Amino-p-nitroaniliden. Z. physiol. Chem. 340, 1–10 (1965).Google Scholar
  109. Neurath, H., Schwert, G.W.: The mode of action of the crystalline pancreatic proteolytic enzymes. Chem. Revs. 46, 69–153 (1950).Google Scholar
  110. Ong, E.B., Shaw, E., Schöllmann, G.: An active center histidine peptide of α-chymotrypsin. J. Amer. Chem. Soc. 86, 1271–1272 (1964).Google Scholar
  111. Pilz, W., Hörlein, H., Johann, I.: Hydrolasen im Vollhomogenat des menschlichen Pankreas. Z. klin. Chem. klin. Biochem. 8, 85–91 (1970).PubMedGoogle Scholar
  112. Pimstone, N.R.: A study of the starch-iodine complex: A modified colorimetric micro determination of amylase in biologic fluids. Clin. Chem. 10, 891–906 (1964).PubMedGoogle Scholar
  113. Ramiz, A., Nipper, H.C., Merchant, C.R., Knoblock, E.C.: Rapid kinetic, turbidimetric microassay of serum lipase activity using the centrifugal fast analyzer. Z. klin. Chem. klin. Biochem. 12, 265 (1974).PubMedGoogle Scholar
  114. Report of the Commission on Enzymes of the International Union of Biochemistry. S. 8. London: Pergamon Press 1961.Google Scholar
  115. Richtlinien der Bundesärztekammer zur Durchführung von Maßnahmen der statistischen Qualitätskontrolle und von Ringversuchen in der Heilkunde. Dtsch. Ärzteblatt 68, 2228–2231 (1971).Google Scholar
  116. Rick, W.: Zur Physiologie und Pathologie der Enzymsekretion des Pankreas. Habilitationsschrift Gießen 1963.Google Scholar
  117. Rick, W.: Zur Pathologie der Enzymsekretion des Pankreas. Acta gastro-ent. belg. 28, 389–400 (1965).Google Scholar
  118. Rick, W.: Zur Bestimmung der Serumlipase bei Pankreaskrankheiten. Verh. Dtsch. Ges. inn. Med. 74, 230–232 (1968).PubMedGoogle Scholar
  119. Rick, W.: In: Schmidt, F.W. (Hrsg.), Praktische Enzymologie, 2. Konferenz der Gesellschaft für Biologische Chemie, Heidelberg 1967. S. 159–162. Bern: Hans Huber 1968.Google Scholar
  120. Rick, W.: Kinetischer Test zur Bestimmung der Serumlipaseaktivität. Z. klin. Chem. klin. Biochem. 7, 530–539(1969).Google Scholar
  121. Rick, W.: Der Secretin-Pankreozymin-Test in der Diagnostik der Pankreasinsuffizienz. Internist 11, 110–117(1970).PubMedGoogle Scholar
  122. Rick, W., Hausamen, T.-U.: Continuous method for the determination of serum lipase activity. Clin. Chem. 14, 796 (1968).Google Scholar
  123. Rick, W., Stegbauer, H.P.: α-Amylase. In: Bergmeyer, H.U. (Hrsg.), Methoden der enzymatischen Analyse. 3. Aufl., S. 918–923. Weinheim: Verlag Chemie 1974.Google Scholar
  124. Riedel, A., Wünsch, E.: Nα-Benzoylarginin-β-naphthylamid als Substrat zur quantitativen kolorime-trischen Bestimmung von Trypsin. Z. physiol. Chem. 316, 61–70 (1959).Google Scholar
  125. Rinderknecht, H., Wilding, P., Haverback, B.J.: A new method for the determination of α-amylase. Experientia 23, 805(1967).PubMedGoogle Scholar
  126. Rinderknecht, H., Silverman, P., Geokas, M.C., Haverback, B.J.: Determination of trypsin and chymotrypsin with remazolbrillant blue-hide. Clin. chim. Acta 28, 239–246 (1970).PubMedGoogle Scholar
  127. Robinson, L.A., Kim, W.J., White, T.T., Hadorn, B.: Trypsins in human pancreatic juice—their distribution as found in 34 specimens. Two human pancreatic trypsinogens. Scand. J. Gastroent. 7, 43–45(1972).PubMedGoogle Scholar
  128. Robyt, J.F., French, D.: The action pattern of porcine pancreatic a-amylase in relationship to the substrate binding site of the enzyme. J. biol. Chem. 245, 3917–3927 (1970).PubMedGoogle Scholar
  129. Roe, J.H., Byler, R.E.: Serum lipase determination using a one-hour period of hydrolysis. Analyt. Biochem. 6, 451–460 (1963).PubMedGoogle Scholar
  130. Sarles, H., Taulier, J., Figarella, C.: Dosage de la lipase dans le suc duodénal. Rev. franc. Étud. clin. biol. 8, 706–707 (1963).PubMedGoogle Scholar
  131. Sarles, H., Worning, H.: Persönliche Mitteilung (1972).Google Scholar
  132. Sax, S.M., Bridgwater, A.B., Moore, J.J.: Determination of serum and urine amylase with use of procion brilliant red M-2 BS amylopectin. Clin., Chem. 17, 311–315 (1971).Google Scholar
  133. Saxon, E.I., Hinkley, W.C., Vogel, W.C., Zieve, L.: Comparative value of serum and urinary amylase in the diagnosis of acute pancreatitis. Arch. int. Med. 99, 607–621 (1957).Google Scholar
  134. Schiwara, H.-W.: Ein UV-Test zur Messung der α-Amylase-Aktivität in Serum und Urin. Z. klin. Chem. klin. Biochem. 10, 12–16 (1972).PubMedGoogle Scholar
  135. Schultis, K., Wagner, E., Vossköhler, E.: Erfahrungen mit Lipasebestimmungen im Serum für die Diagnostik akuter und chronischer Pankreaserkrankungen. Schweiz, med. Wschr. 99, 603–606 (1969).Google Scholar
  136. Schwert, G.W., Takenaka, Y.: A spectrophotometric determination of trypsin and chymotrypsin. Biochim. biophys. Acta 16, 570–575 (1955).PubMedGoogle Scholar
  137. Searcy, R.L., Wilding, P., Berk, J.E.: An appraisal of methods for serum amylase determination. Clin. chim. Acta 15, 189–197 (1967).Google Scholar
  138. Searcy, R.L., Hayashi, S., Berk, J.E.: A new micro saccharogenic method for serum amylase determination. Amer. J. clin. Path. 46, 582–586 (1966).Google Scholar
  139. Shapira, E., Arnon, R., Russell, A.: Specific immunoassay for quantitative determination of human trypsin in intestinal content. J. Lab. clin. Med. 77, 877–884 (1971).PubMedGoogle Scholar
  140. Shihabi, Z.K., Bishop, C.: Simplified turbidimetric assay for lipase activity. Clin. Chem. 17, 1150–1153 (1971).PubMedGoogle Scholar
  141. Shotton, D.M., Hartley, B.S.: Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases. Nature 225, 802–806 (1970).PubMedGoogle Scholar
  142. Shotton, D.M., Watson, H.C.: Three-dimensional structure of tosyl-elastase. Nature 225, 811–816 (1970).PubMedGoogle Scholar
  143. Silberberg, V.L., Hadorn, B.: Identification of pancreatic enzymes in human duodenal contents. Biochim. biophys. Acta 167, 616–619 (1968).PubMedGoogle Scholar
  144. Somogyi, M.: Micromethods for the estimation of diastase. J. biol. Chem. 125, 399–414 (1938).Google Scholar
  145. Stein, E.A., Fischer, E.H.: The resistence of a-amylase towards proteolytic attack. J. biol. Chem. 232, 867–879 (1958).PubMedGoogle Scholar
  146. Stein, E.A., Hsiu, J., Fischer, E.H.: Alpha-amylases as calcium metalloenzymes. I. Preparation of calcium-free apoamylases by chelation and electrodialysis. Biochemistry 3, 56–61 (1964).PubMedGoogle Scholar
  147. Straumfjord, J.B., Copeland, B.E.: Clinical chemistry quality control values in thirty-three university medical school hospitals. Amer. J. clin. Path. 44, 252–258 (1965).Google Scholar
  148. Street, H.V.: Serum amylase activity, its determination in health and diabetes mellitus. Clin. chim. Acta 3, 501 – 513 (1958).PubMedGoogle Scholar
  149. Street, H.V., Close, J.R.: Determination of amylase activity in biological fluids. Clin. chim. Acta 1, 256–268 (1956).PubMedGoogle Scholar
  150. Sumner, J.B.: Dinitrosalicylic acid: A reagent for the estimation of sugar in normal and diabetic urine. J. biol. Chem. 47, 5–9 (1921).Google Scholar
  151. Temler, R.S., Felber, J.-P.: Radioimmunoassay of enzymes of the exocrine pancreas (trypsin, chymotrypsin, chymotrypsinogen). Biochim. biophys. Acta 236, 78–83 (1971).PubMedGoogle Scholar
  152. Thoma, J.A., Spradlin, J.E., Dygert, S.: Plant and animal amylases. In: Boyer, P.D. (Ed.), The Enzymes. 3. Aufl., Vol. V, S. 115–189. New York: Academic Press 1971.Google Scholar
  153. Tietz, N.W., Fiereck, E.A.: A specific method for serum lipase determination. Clin. chim. Acta 13, 352–358 (1966).PubMedGoogle Scholar
  154. Tietz, N., Fiereck, E.A.: Measurement of lipase activity in serum. In: Cooper, G.R. (Ed.), Standard methods of clinical chemistry. Vol. 7, S. 19–31. New York: Academic Press 1972.Google Scholar
  155. Tietz, N.W., Repique, E.V.: Proposed standard method for measuring lipase activity in serum by a continuous sampling technique. Clin. Chem. 19, 1268–1275 (1973).PubMedGoogle Scholar
  156. Travis, J., Roberts, R.C.: Human trypsin. Isolation and physical-chemical characterization. Biochemistry 8, 2884–2889 (1969).PubMedGoogle Scholar
  157. Turvey, J.R.: Polysaccharases. In: Lang, K., Lehnartz, E. (Hrsg.), Handbuch der physiologisch-und pathologisch-chemischen Analyse. Bd. VI B, S. 1123–1156. Berlin: Springer-Verlag 1966.Google Scholar
  158. Ujihira, I., Searcy, R.L., Berk, J.E., Hayashi, S.: A saccharogenic method for estimating electro-phoretic and chromatographic distribution of human serum amylase. Clin. Chem. 11, 97–112 (1965).PubMedGoogle Scholar
  159. Vandermeers, A., Vandermeers, M.C., Rathe, J., Christophe, J.: On human pancreatic triacylglycerol lipase: Isolation and some properties. Biochim. biophys. Acta 370, 257–268 (1974).PubMedGoogle Scholar
  160. Verduin, P.A., Punt, J.M.H.M., Kreutzer, H.H.: Studies on the determination of lipase activity. Clin. chim. Acta 46, 11–19 (1973).PubMedGoogle Scholar
  161. Vogel, W.C., Zieve, L.: A rapid and sensitive turbidimetric method for serum lipase based upon differences between the lipases of normal and pancreatitis serum. Clin. Chem. 9, 168–181 (1963).PubMedGoogle Scholar
  162. Waller, S.L., Ralston, A.J.: The hourly rate of urinary amylase excretion, serum amylase, and serum lipase. Gut 12, 878–890 (1971).PubMedGoogle Scholar
  163. Walsh, K.A., Kauffman, D.S., Sampath-Kumar, K.S.V., Neurath, H.: On the structure and function of bovine trypsinogen and trypsin. Proc. Nat. Acad. Sci. U.S. 51, 301–308 (1964).Google Scholar
  164. Warburg, O., Christian, W., Griese, A.: Wasserstoffübertragendes Co-Ferment, seine Zusammensetzung und Wirkungsweise. Biochem. Z. 282, 157–205 (1935).Google Scholar
  165. Ware, A.G., Walberg, C.B., Sterling, R.E.: Turbidimetric measurement of amylase: Standardization and control with stable serum. In: Seligson, D. (Ed.), Standard methods of clinical chemistry 5, S. 15–21. New York: Academic Press 1963.Google Scholar
  166. Weber, H.: Mikromethode zur Bestimmung der Pankreaslipase im Serum. Dtsch. med. Wschr. 90, 1170–1174(1965).PubMedGoogle Scholar
  167. Whitaker, J.R., Menger, F., Bender, M.L.: The kinetics of some carboxypeptidase A and acetyl-carboxypeptidase A catalyzed hydrolyses. Biochemistry 5, 386–392 (1966).PubMedGoogle Scholar
  168. Whitaker, J.G.: A rapid and specific method for the determination of pancreatic lipase in serum and urine. Clin. chim. Acta 44, 133–138 (1973).PubMedGoogle Scholar
  169. Wilding, P.: Use of gel filtration in the study of human amylase. Clin. chim. Acta 8, 918–924 (1963).PubMedGoogle Scholar
  170. Wilding, P., Cooke, W.T., Nicholson, G.T.: Globulin-bound amylase: A cause of persistently elevated levels in serum. Ann. int. Med. 60, 1053–1059 (1964).Google Scholar
  171. Wintersberger, E., Cox, D.J., Neurath, H.: Bovine pancreatic procarboxypeptidase B. I. Isolation, properties, and activation. Biochemistry 1, 1069–1078 (1962).PubMedGoogle Scholar
  172. Wohlgemuth, J.: Über eine neue Methode zur quantitativen Bestimmung des diastatischen Ferments. Biochem. Z. 9, 1–9 (1908).Google Scholar
  173. Wünsch, E., Högel-Betz, A., Jaeger, E.: Ein neues Substrat zur quantitativen Bestimmung von Chymotrypsin A. Z. physiol. Chem. 352, 1553–1559 (1971).Google Scholar
  174. Zinterhofer, L., Wardlaw, S., Jatlow, P., Seligson, D.: Nephelometric determination of pancreatic enzymes. I. Amylase. Clin. chim. Acta 43, 5–12 (1973).PubMedGoogle Scholar
  175. Zinterhofer, L., Wardlaw, S., Jatlow, P., Seligson, D.: Nephelometric determination of pancreatic enzymes. II. Lipase. Clin. chim. Acta 44, 173–178 (1973).Google Scholar

Literatur

  1. 1.
    Yalow, R.S., Berson, S.A.: Nature 21, 1648 (1959).Google Scholar
  2. 2.
    Skelley, D.S., Brown, L.P., Besch, P.K.: Clin. Chem. 19, 146 (1973).PubMedGoogle Scholar
  3. 3.
    Geerling, H., Angel, H. J., Löffler, G., Weinges, K.F.: Dtsch. Med. Wschr. 90, 825 (1965).PubMedGoogle Scholar
  4. 4.
    Ditschuneit, H., Faulhaber, I.D.: In: Handbuch des Diabetes mellitus, Pfeiffer, E.F., Hrsg. Bd. II, S. 41. München: J.F. Lehmanns 1971.Google Scholar
  5. 5.
    Schöffling, K., Beyer, J., Althoff, P., Walter, A., Ditschuneit, H., Melani, F., Ditschuneit, H.H., Ammon, J., Pfeiffer, E.F.: Diabetologia 1, 77 (1965).Google Scholar
  6. 6.
    Melani, F., Ditschuneit, H., Barthelt, K.M., Friedrich, H., Pfeiffer, E.F.: Klin. Wschr. 43, 1000(1965).PubMedGoogle Scholar
  7. 7.
    Armin, J., Grant, R.T., Wright, Ph.: J. Physiol. 153, 131 (1960).PubMedGoogle Scholar
  8. 8.
    Soeldner, J.S., Slone, D.: Diabetes 14, 771 (1965).PubMedGoogle Scholar
  9. 9.
    Samols, E., Bickus, D.: Proc. Soc. exp. Biol. (N.Y.) 115, 79 (1964).Google Scholar
  10. 10.
    Robinson, B.H.B., Wright, P.H.: J. Physiol. 155, 302 (1961).PubMedGoogle Scholar
  11. 11.
    Ceska, M., Grossmüller, F., Lundkvist, U.: Acta Endocr. 64, 111 (1970).Google Scholar
  12. 12.
    Siess, E., Teinzer, A., Wieland, O.: Diabetologia, 1, 201 (1965).Google Scholar
  13. 13.
    Greenwood, F.C., Hunter, W.M., Glover, J.S.: Biochem. J. 89, 114 (1962).Google Scholar
  14. 14.
    Melani, F., Barthelt, K.M., Conrads, R., Pfeiffer, E.F.: Z. klin. Chem. 4, 189 (1966).Google Scholar
  15. 15.
    Glover, J.S., Salter, D.N., Shepherd, B.P.: Biochem. J. 103, 120 (1967).PubMedGoogle Scholar
  16. 16.
    Löffler, G., Gruber, R., Brauch, M., Wieland, O., Mehnert, H.: Verhdl. Dtsch. Ges. Inn. Med. 78, 269 (1972).Google Scholar
  17. 17.
    Heding, L.G.: Horm. Metab. Res. 1, 145 (1969).PubMedGoogle Scholar
  18. 18.
    Genuth, S., Frohman, L.H., Lebovitz, H.E.: J. Clin. Endocr. 25, 1043 (1965).PubMedGoogle Scholar
  19. 19.
    Samols, E., Bilkus, D.: Proc. Soc. exp. Biol. (N.Y.) 115, 79 (1963).Google Scholar
  20. 20.
    Makulu, D.R., Vichick, D., Wright, P.H., Sussman, K.E., Yu, P.L.: Diabetes 18, 660 (1969).PubMedGoogle Scholar
  21. 21.
    Hales, C.N., Randle, P.J.: Biochem. J. 88, 137 (1963).PubMedGoogle Scholar
  22. 22.
    Herbert, V., Kam-Seng Lau, Gottlieb, Ch.W., Bleicher, Sh.: J. Endocr. 25, 1375 (1965).Google Scholar
  23. 23.
    Keane, P.M., Pearson, J., Walter, W.H.C.: Diabetologia 4, 339 (1968)PubMedGoogle Scholar
  24. 24.
    Trautschold, J., Lohmann, E., Dornow, H., Löffler, G.: Abstr. VII th. Int. Congr. Clin. Chem., Genéve, Sept. 8–13, 1969.Google Scholar
  25. 25.
    Löffler, G., Weiss, L.: Mitt. der dtsch. Ges. klin. Chem., Heft 3, S. 61 (1971).Google Scholar
  26. 26.
    Poznanski, N., Poznanski, W.J.: Clin. Chem. 15, 908 (1969).PubMedGoogle Scholar
  27. 27.
    Biro, G., Weinges, K.F.: Med. Lab. 26, 181 (1973).Google Scholar
  28. 28.
    Grodsky, G., Forsham, H.P.: J. clin. Invest. 39, 1070 (1960).PubMedGoogle Scholar
  29. 29.
    Morgan, C.R., Lazarow, A.: Diabetes 12, 115 (1963).Google Scholar
  30. 30.
    Morgan, C.R., Sorenson, R.L., Lazarow, A.: Diabetes 13, 579 (1964).PubMedGoogle Scholar
  31. 31.
    Meade, R.C., Klitgaard, H.M.: J. nucl. Med. 3, 407 (1962).PubMedGoogle Scholar
  32. 32.
    Zaharko, D.S., Beck, V.C.: Diabetes 17, 444 (1968).PubMedGoogle Scholar
  33. 33.
    Wide, L., Porath, J.: Biochem. Biophys. Acta 130, 257 (1966).Google Scholar
  34. 34.
    Brodal, B.P.: Scand. J. clin. Lab. Invest. 28, 287 (1971).PubMedGoogle Scholar
  35. 35.
    Midgley, A.R. Jr., Niswender, G.D., Regar, R.W.: Acta Endocr. 63, Suppl. 142, 163 (1969).Google Scholar
  36. 36.
    Rodbard, D., Bridson, W., Rayford, P.L.: J. Lab. clin. Med. 74, 770 (1969).PubMedGoogle Scholar
  37. 37.
    Rodbard, D., Rayford, P.L., Cooper, J.A., Ross, G.T.: J. clin. Endocr. 28, 1412 (1968).PubMedGoogle Scholar
  38. 38.
    Burger, H.G., Lee, V.W.K., Rennie, G.C.: J. Lab. clin. Med. 80, 302 (1972).PubMedGoogle Scholar
  39. 39.
    Täljedal, J.-B., Wold, S.: Biochem. J. 117, 139 (1970).Google Scholar
  40. 40.
    Otto, H.: Persönliche Mitteilung.Google Scholar
  41. 41.
    Marschner, J.: Persönliche Mitteilung.Google Scholar
  42. 42.
    Rubenstein, A.H., Melani, F., Steiner, D.F.: In Steiner, D.F., Freinkel, N. (Eds.): Handbook of Physiology, Sect. 7, Vol. 1, pp. 515. Boston: Williams and Wilkins Comp. 1972.Google Scholar
  43. 43.
    Gordon, P., Roth, J.: Arch. Intern. Med. 123, 237 (1969).Google Scholar
  44. 44.
    Ashford, W.R., Campbell, J., Davidson, J.K., Fisher, A.M., Haist, R.E., Lacey, A.H., Lin, B., Martin, J.M., Morley, N.H., Rastogi, K., Storvick, W.O.: Diabetes 18, 828 (1969).PubMedGoogle Scholar
  45. 45.
    Melani, F.: In: Pfeiffer, E.F. (Hrsg.): Handbuch des Diabetes mellitus. Bd. II, S. 69. München: S.F.Lehmanns 1971.Google Scholar
  46. 46.
    Yalow, R.S., Berson, S.A.: J. clin. Invest. 39, 1157 (1960).PubMedGoogle Scholar
  47. 47.
    Löffler, G., Weiss, L.: In: Methoden der Hormonbestimmung (Breuer, H., Hamel, D., Krüskemper, H.L., Hrsg.). Stuttgart: Thieme 1975.Google Scholar
  48. 48.
    Feldman, J.M., Chapman, B.A.: Clin. Chem. 19, 1250 (1973).PubMedGoogle Scholar
  49. 49.
    Soeldner, L.S., Sawin, C.T., Silbert, C.K., Mitchell, M.L.: Metabolism 23, 209 (1974).PubMedGoogle Scholar
  50. 50.
    Marschner, L., Bottermann, P., Erhardt, F., Linke, R., Löffler, G., Maier, V., Schwandt, P., Vogt, W., Scriba, P.C.: Horm. Metab. Res. 6, 292 (1974).Google Scholar
  51. 51.
    Vranic, M., Pek, S., Kawamori, R.: Diabetes 23, 905 (1974).PubMedGoogle Scholar
  52. 52.
    Morita, S., Yip, C., Vranic, M.: 57th Ann. Mtg., Endocr. Soc, New York, 18.20.6.1975, abstract No. 71, p. 86(1975).Google Scholar
  53. 53.
    Matsuyama, T., Foà, P.P.: Diabetes 23, Suppl. 1, 344 (1974).Google Scholar
  54. 54.
    Sasaki, H., Rubalcava, B., Baetens, D., Blazquez, E., Srikant, C.B., Orci, L., Unger, R.H.: J. Clin. Invest. 56, 135(1975).PubMedGoogle Scholar
  55. 55.
    Staub, A., Sinn, L.G., Behhrens, O.K.: J. Biol. Chem. 241, 619 (1955).Google Scholar
  56. 56.
    Bromer, W.W., Sinn, L.G., Staub, A., Behrens, O.K.: J. Am. chem. Soc. 78, 3858 (1956).Google Scholar
  57. 57.
    Sokal, J.E., Ezdinle, E.Z.: J. Clin. Invest. 46, 118 (1967).Google Scholar
  58. 58.
    Marco, J., Faloona, G.R., Unger, R.H.: J. Clin. Invest. 50, 1650 (1971).PubMedGoogle Scholar
  59. 59.
    Berson, S.A., Yalow, R.S.: Advances in Biological and Medical Physics. Vol. 6, p. 369. New York: Academic Press 1958.Google Scholar
  60. 60.
    Unger, R.H., Eisentraut, A.M., McCall, M.S., Keller, S., Lanz, H.C., Madison, L.L.: Proc. Soc. Exptl. Biol. Med. 102, 621 (1959).Google Scholar
  61. 61.
    Unger, R.H., Eisentraut, A.M., McCall, M.S., Madison, L.L.: J. Clin. Invest. 40, 1280 (1961).PubMedGoogle Scholar
  62. 62.
    Unger, R.H., Eisentraut, A.M., McCall, M.S., Madison, L.L.: J. Clin. Invest. 41, 682 (1962).PubMedGoogle Scholar
  63. 63.
    Sokal, J.E.: In: Glucagon Molecular Physiology, Clinical and Therapeutical Implications (Lefebvre, P.J., Unger, R.H., Eds.). Chapter 18, p. 275. Oxford: Pergamon Press 1972.Google Scholar
  64. 64.
    Unger, R.H., Ketterer, H., Dupré, J., Eisentraut, A.M.: J. Clin. Invest. 46, 630 (1967).PubMedGoogle Scholar
  65. 65.
    Eisentraut, A.M., Ohneda, A., Aguilar-Parada, E., Unger, R.H.: Diabetes 17, 320 (abstract) (1968).Google Scholar
  66. 66.
    Aguilar-Parada, E., Eisentraut, A.M., Unger, R.H.: Am. J. Med. Sci. 257, 415 (1969).PubMedGoogle Scholar
  67. 67.
    Park, C.R., Exton, J.H.: In Glucagon. Chapter 6, p. 77 (Lefebvre, P.J., Unger, R.H. Eds.). Oxford: Pergamon Press 1972.Google Scholar
  68. 68.
    Marliss, E.B., Aoki, T.T., Cahill Jr., G.F.: In: Glucagon. Chapter 8, p. 123 (Lefebvre, P.J., and Unger, R.H., Eds.). Oxford: Pergamon Press 1972.Google Scholar
  69. 69.
    Unger, R.H., Lefebvre, P.J.: In: Glucagon. Chapter 15, p. 213 (Lefebvre, P.J., Unger, R.H. ed.). Oxford: Pergamon Press 1972.Google Scholar
  70. 70.
    Lefebvre, P.J.: In: Glucagon. Chapter 7, p. 109 (Lefebvre, P.J., Unger, R.H., Eds.). Oxford: Pergamon Press 1972.Google Scholar
  71. 71.
    Unger, R.H., Eisentraut, A.M.: In: Hormones in Blood, Vol. 1, Chapter V, p. 83. (Grey, C.H., Bacharach, A.L. ed.) London-New York: 1967.Google Scholar
  72. 72.
    Müller, W.A., Faloona, G.R., Unger, R.H.: J. Clin. Invest. 50, 1992 (1971).PubMedGoogle Scholar
  73. 73.
    Heding, L.G.: Diabetologia 7, 10 (1971).PubMedGoogle Scholar
  74. 74.
    Marreiro Rocha, D., Santeusanio, F., Faloona, G.R., Unger, R.H.: N. Engl. J. Med. 288, 700(1973).Google Scholar
  75. 75.
    Santeusanio, F., Faloona, G.R., Unger, R.H.: J. Clin. Invest. 51, 1743 (1972).PubMedGoogle Scholar
  76. 76.
    Faloona, G.R.: In: Methods in Investigative and Diagnostic Endocrinology, Non Pituitary Hormones (ed. S.A. Berson, R. Yalow), p. 919. Amsterdam: North Holland Publishing Co. 1973Google Scholar
  77. 77.
    Faloona, G.R., Unger, R.H.: In: Methods of Hormone Radioimmunoassay, (ed. B.M. Jaffe, H.R. Behrmann), p. 317. New York: Academic Press 1974.Google Scholar
  78. 78.
    Faloona, G.R., Böttger, L., Eisentraut, A.M.: In: Methoden der Hormonbestimmung. (Hrsg. H. Breuer et al.), S. 98. Stuttgart: G. Thieme Verlag 1975.Google Scholar
  79. 79.
    Bloom, S.R.: Diabetologia 7, 472 (1971).Google Scholar
  80. 80.
    Buchanan, K.D., McCarroll, A.M.: In: Radioimmunoassay Methods (ed. Kirkham, K.E., Hunter, W.M.), p. 266. Edinburgh: E. and S. Livingstone 1971.Google Scholar
  81. 81.
    Holst, J.J., Aasted, B.: Acta endocrinol. 77, 715 (1975).Google Scholar
  82. 82.
    Galbo, H., Holst, J.J., Christensen, N.J.: J. Appl. Physiol. 38, 70 (1975).PubMedGoogle Scholar
  83. 83.
    Fajans, S.S., Quibrera, R., Pek, S., Floyd Jr., J.C., Christensen, H.N., Conn, J.W.: J. Clin. Endocrinol. Metab. 33, 35 (1971).PubMedGoogle Scholar
  84. 84.
    Sperling, M.A., DeLamater, P.V., Kazenelson, M., Fiser, R.H., Fisher, D.A.: Clin. Chem. 20, 566(1974).PubMedGoogle Scholar
  85. 85.
    Buchanan, K.D., McCarroll, A.M.: Lancet 1972II, 1394.Google Scholar
  86. 86.
    Tan, M.H., Böttger, I., Unger, R.H., Soeldner, J.S., Faloona, G.R., Gleason, R.E.: Diabetes (eingereicht, 1975).Google Scholar
  87. 87.
    Pek, S., Fajans, S.S., Floyd, J.C., Knopf, R.F., Conn, J.W.: Diabetes 21, Suppl. 1, 324 (1972).Google Scholar
  88. 88.
    Lawrence, A.M.: Proc. Nat. Acad. Sci. (USA) 55, 316 (1966).Google Scholar
  89. 89.
    Goldfine, I.D., Ryan, W.G.: Horm. Metab. Res. 2, 47 (1970).PubMedGoogle Scholar
  90. 90.
    Probst, G.W., Colwel, R.W.: Biochem. 5, 1209 (1966).Google Scholar
  91. 91.
    Young, J.D., Jenkinson, I.S.: Austral. J. exp. Biol. Med. Sci. 46, 707 (1968).Google Scholar
  92. 92.
    Assan, R., Rosselin, G., Drouet, G., Dolais, J., Tchobroutsky, G.: Lancet 1965II, 590.Google Scholar
  93. 93.
    Goodfriend, T.L., Levine, L., Fasman, G.D.: Science 144, 1344 (1964).PubMedGoogle Scholar
  94. 94.
    Heding, L.G.: Horm. Met. Res. 1, 87 (1969).Google Scholar
  95. 95.
    Frohman, L.A., Reichlin, M., Sokal, J.E.: Endocrinology 87, 1055 (1970).PubMedGoogle Scholar
  96. 96.
    Kologlu, Y., Wiesel, L.L., Positano, V., Anderson, G.E.: Proc. Soc. exp. Biol. Med. 112, 518(1963).PubMedGoogle Scholar
  97. 97.
    Grey, N., McGuigan, J.E., Kipnis, D.M.: Endocrinology 86, 1383 (1970).PubMedGoogle Scholar
  98. 98.
    Heding, L.: In: Glucagon. Chapter 12, p. 187 (Lefebvre et al). Oxford: Pergamon Press 1972.Google Scholar
  99. 99.
    Assan, R., Tchobroutsky, G., Rosselin, G.: Path. biol. 17, 747 (1969).Google Scholar
  100. 100.
    Assan, R., Drouet, J., Rosselin, G., Wünsch, E., Schröder, E.: Path. Biol. 17, 757 (1969).Google Scholar
  101. 101.
    Faloona, G.R.: In: Glucagon. Chapter 13, p. 201 (ed. Lefebvre, P.J., and Unger, R.H.). Oxford: Pergamon Press 1972.Google Scholar
  102. 102.
    Assan, R., Rosselin, G., Tchobroutsky, G., Freychet, P.: Path. Biol. 17, 45 (1969).Google Scholar
  103. 103.
    Weinges, K.F., Wünsch, E., Biro, G., Kettl, H., Mitzuno, M.: Diabetologia 5, 97 (1969).PubMedGoogle Scholar
  104. 104.
    Rigopoulou, D., Valverde, I., Marco, J., Faloona, G., Unger, R.H.: J. Biol. Chem. 245, 496 (1970).PubMedGoogle Scholar
  105. 105.
    Unger, R.H., Eisentraut, A.M.: In: Proteins and Polypeptide Hormones, (ed. M. Margoulis) p. 84. Amsterdam: Exerpta Medica Foundation 1968.Google Scholar
  106. 106.
    Moody, A.J.: In: Glucagon. Chapter 21, p. 319 (ed. Lefebvre, P.J., Unger, R.H.). Oxford: Pergamon Press 1972.Google Scholar
  107. 107.
    Luyckx, A.S.: In: Glucagon. Chapter 19, p. 285 (ed. Lefebvre, P.J., Unger, R.H.). Oxford: Pergamon Press 1972.Google Scholar
  108. 108.
    Sakwai, H., Imura, H.: Jap. J. Nucl. Med. 10, 135 (1973).Google Scholar
  109. 109.
    Blàzquez, E., Sugase, T., Blàzquez, M., Foà, P.P.: J. Lab. Clin. Med. 83, 957 (1974).PubMedGoogle Scholar
  110. 110.
    Assan, R., Boillot, J.: Path. Biol. 21, 149 (1973).Google Scholar
  111. 111.
    Baum, J., Simons, B.E., Unger, R.H., Madison, L.L.: Diabetes 11, 371 (1962).PubMedGoogle Scholar
  112. 112.
    Schopmann, W., Hackeng, W.H.L., Steendijk, C.: Acta Endocrin. 54, 527 (1967).Google Scholar
  113. 113.
    Hazzard, W.R., Crockford, P.M., Buchanan, K.D., Vance, J.E., Chen, R., Williams, R.H.: Diabetes 17, 179(1968).PubMedGoogle Scholar
  114. 114.
    Senyk, G., Nitecki, D.E., Goodman, J.W.: Science 171, 407 (1971).PubMedGoogle Scholar
  115. 115.
    Senyk, G., Nitecki, D.E., Goodman, J.W.: Exp. Med. 133, 1294 (1971).Google Scholar
  116. 116.
    Goldfine, I.D., Ryan, W.G.: Horm. Metab. Res. 2, 47 (1970).PubMedGoogle Scholar
  117. 117.
    Leclercq-Meyer, V., Mialhe, P., Malaisse, W.J.: Diabetologia 6, 121 (1970).PubMedGoogle Scholar
  118. 118.
    Frohman, L.A., Reichlin, M., Sokal, J.E.: Endocrinology 87, 1055 (1970).PubMedGoogle Scholar
  119. 119.
    Shima, K., Foà, P.P.: Clin. Chim. Acta 22, 511 (1968).PubMedGoogle Scholar
  120. 120.
    Senyk, G., Nitecki, D.E., Spitler, L., Goodman, J.W.: Immunochem. 9, 97 (1972).Google Scholar
  121. 121.
    Unger, R.H.: In: Glucagon. Chapter 14, p. 205 (ed. Lefebvre, P.J., Unger, R.H.). Oxford: Pergamon Press 1972.Google Scholar
  122. 122.
    Edwards, J.C., Howell, S.L., Taylor, K.W.: Biochem. Biophys. Acta 215, 297 (1970).PubMedGoogle Scholar
  123. 123.
    Fussgänger, R.D., Straub, K., Goberna, R., Jaros, P., Schröder, K.E., Raptis, S., Pfeiffer, E.F.: Horm. Metab. Res. 1, 224 (1969).PubMedGoogle Scholar
  124. 124.
    Eaton, R.P.: Am. J. Physiol. 225, 67 (1973).PubMedGoogle Scholar
  125. 125.
    Barling, P., Beloff-Chain, A.: Horm. Metab. Res. 5, 154 (1973).PubMedGoogle Scholar
  126. 126.
    Unger, R.H., Eisentraut, A.M., Madison, L.L.: J. Clin. Invest. 42, 1031 (1963).PubMedGoogle Scholar
  127. 127.
    Unger, R.H., Eisentraut, A.M.: Diabetes 13, 563 (1964).PubMedGoogle Scholar
  128. 128.
    Aguilar-Parada, E., Eisentraut, A.M., Unger, R.H.: Diabetes 18, 717 (1969).PubMedGoogle Scholar
  129. 129.
    Müller, W.A., Faloona, G.R., Aguilar-Parada, E., Unger, R.H.: New Engl. J. Med. 282, 109(1970).Google Scholar
  130. 130.
    Unger, R.H., Aguilar-Parada, E., Müller, W.A., Eisentraut, A.M.: J. Clin. Invest, 49, 837(1970).PubMedGoogle Scholar
  131. 131.
    Böttger, J., Dobbs, R., Faloona, G.R., Unger, R.H.: J. Clin. Invest. 52, 2532 (1973).PubMedGoogle Scholar
  132. 132.
    Berson, S.A., Yalow, R.S., Volk, B.W.: J. Lab. Clin. Med. 49, 331 (1951).Google Scholar
  133. 133.
    Jørgensen, K.H., Larsen, U.D.: Horm. Metab. Res. 4, 223 (1972).PubMedGoogle Scholar
  134. 134.
    Eisentraut, A.M., Whissen, N., Unger, R.H.: Am. J. Med. Sci. 255, 137 (1968).PubMedGoogle Scholar
  135. 135.
    Mirsky, I.A., Perisutti, G., Davis, H.C.: Endocrinology 64, 992 (1959).PubMedGoogle Scholar
  136. 136.
    Weir, G.C., Turner, R.C., Martin, D.B.: Horm. Metab. Res. 5, 241 (1973).PubMedGoogle Scholar
  137. 137.
    Nonaka, K., Foà, P.P.: Proc. Soc. Exptl. Biol. Med. 130, 330 (1969).Google Scholar
  138. 138.
    Leclercq-Meyer, V., Mialhe, P., Malaisse, W.J.: Diabetologia 6, 121 (1970).PubMedGoogle Scholar
  139. 139.
    Kaneto, A., Mizuno, Y., Tasaka, Y., Kosaka, K.: Endocrinology 86, 1175 (1970).PubMedGoogle Scholar
  140. 140.
    Valverde, I., Rigopoulou, D., Marco, J., Faloona, G.R., Unger, R.H.: Diabetes 19, 624 (1970).PubMedGoogle Scholar
  141. 141.
    Unger, R.H., Eisentraut, A.M., Sims, K., McCall, M.S., Madison, L.L.: Clin. Res. 9, 53 (1961).Google Scholar
  142. 142.
    Marco, J., Faloona, G.R., Unger, R.H.: J. Clin. Endocr. Metab. 33, 318 (1971).PubMedGoogle Scholar
  143. 143.
    Unger, R.H., Ohneda, A., Valverde, L., Eisentraut, A.M., Exton, J.: J. Clin. Invest. 47, 48 (1968).PubMedGoogle Scholar
  144. 144.
    Gottlieb, C.W., Lau, K.S., Wassermann, C.R., Herbert, V.: Blood 25, 875 (1965).Google Scholar
  145. 145.
    Assan, R., Rosselin, G., Dolais, J.: Journées annuelles de Diabétologie de l’Hôtel-Dieu, pp. 25–41. Paris: Ed. Médicales Flammarion 1967.Google Scholar
  146. 146.
    Luyckx, A.S., Lefebvre, P.J.: Proc. Soc. Exptl. Biol. Med. 133, 524 (1970).Google Scholar
  147. 147.
    Ørskov, H., Yde, H., Thomsen, H.G.: Nature (London) 219, 193 (1968).Google Scholar
  148. 148.
    Grodsky, G.M., Hayashida, T., Peng, C.T., Geschwind, I.I.: Proc. Soc. Exp. Biol. Med. 107, 491(1961).PubMedGoogle Scholar
  149. 149.
    Desbuquois, B., Aurbach, G.D.: J. Clin. Endocr. 33, 732 (1971).PubMedGoogle Scholar
  150. 150.
    Cherney, T.M.C., Schofield, J.G.: Diabetes 18, 627 (1969).Google Scholar
  151. 151.
    Henquin, J.C., Malvaux, P., Lambert, A.E.: Diabetologia 10, 61 (1974).PubMedGoogle Scholar
  152. 152.
    Schalch, D.S.: J. Clin. Invest. 45, 1068 (1966).Google Scholar
  153. 153.
    Taylor, K.W., Howell, S.L., Montague, W., Edwards, J.C.: Clin. Chim. Acta 22, 71 (1968).PubMedGoogle Scholar
  154. 154.
    Day, J.L., Knight, M., London, J.R.: Clin. Sci. 43, 597 (1972).PubMedGoogle Scholar
  155. 155.
    Nonaka, K., Foà, P.P.: Proc. Soc. Exp. Biol. (N.Y.) 130, 330 (1969).Google Scholar
  156. 156.
    Weinges, K.F.: Labeled Proteins in Tracer Studies. Ed. European Atomic Energy Community Euratom, p. 271, 1968.Google Scholar
  157. 157.
    Seino, Y., Goto, Y., Taminato, T., Ikeda, M., Imura, H.: J. Clin. Endocrinol. Metab. 38, 1136(1974).PubMedGoogle Scholar
  158. 158.
    Rosselin, G., Assan, R., Yalow, R.S., Berson, S.A.: Nature 212, 355 (1966).PubMedGoogle Scholar
  159. 159.
    Sutherland, E.W., DeDuve, G.: J. Biol. Chem. 175, 663 (1948).PubMedGoogle Scholar
  160. 160.
    Samols, E., Tyler, J., Megyesi, C., Marks, Y.: Lancet 1966II, 127.Google Scholar
  161. 161.
    Unger, R.H., Eisentraut, A.M., Sims, K., McCall, M.S., Madison, L.L.: Clin. Res. 9, 53(1961).Google Scholar
  162. 162.
    Unger, R.H., Ketterer, H., Eisentraut, A.M.: Metabolism 15, 865 (1966).PubMedGoogle Scholar
  163. 163.
    Schopman, W., Hackeng, W.H., Lequin, R.M., Persson, H.P.M.: Acta Physiol. Pharmacol. Neerlandica 14, 522(1967).Google Scholar
  164. 164.
    Samols, E., Tyler, J., Marri, U., Marks, V.: Lancet 7424, 1287 (1965).Google Scholar
  165. 165.
    Müller, W.A.: Helvetia Medica Acta 37, 321 (1974).Google Scholar
  166. 166.
    Rodbell, M., Kraus, M.J., Rohl, S.L., Birnbaumer, L.: J. Biol. Chem. 246, 1861 (1971).PubMedGoogle Scholar
  167. 167.
    Bataille, D.P., Freychet, P., Kitabgi, P., Rosselin, G.: FEBS-Lett. 30, 215 (1973).PubMedGoogle Scholar
  168. 168.
    Beck, P., Hales, C.N.: Biochem. J. 145, 607 (1975).PubMedGoogle Scholar
  169. 169.
    Matsuyama, T., Foà, P.P.: Proc. Soc. Exp. Biol. Med. 147, 97 (1974).PubMedGoogle Scholar
  170. 170.
    Bloom, S.R.: Gut 13, 520 (1972).PubMedGoogle Scholar
  171. 171.
    Zandomeneghi, R., Buchanan, K.D.: Diabetologia 8, 283 (1972).PubMedGoogle Scholar
  172. 172.
    Ensinck, J.W., Shepard, C., Dudl, R.J., Williams, R.H.: J. Clin. Endocrinol. Metab. 35, 463(1972).PubMedGoogle Scholar

Literatur

  1. Anderson, J.C., Barton, M.A., Gregory, R.A., Hardy, P.M., Kenner, G.W., McLeod, J.K., Preston, J., Shepard, R.C., Morley, J.S.: The antral hormone gastrin: IL Synthesis of gastrin. Nature (Lond.) 204, 933–934 (1964).Google Scholar
  2. Arnold, R., Fuchs, K., Siewert, R., Peiper, H.-J., Creutzfeldt, W.: Zur Morphologie, Klinik, Diagnostik und Therapie des Zollinger-Ellison-Syndroms. Dtsch. med. Wschr. 99, 607–616 (1974).PubMedGoogle Scholar
  3. Berry, H., Flower, R.J.: The assay of endogenous cholecystokinin and factors influencing its release in the dog and cat. Gastroenterology 60, 409–420 (1971).PubMedGoogle Scholar
  4. Berson, S.A., Yalow, R.S.: Nature of immunoreactive gastrin extracted from tissues of gastrointestinal tract. Gastroenterology 60, 215–222 (1971).PubMedGoogle Scholar
  5. Berson, S.A., Yalow, R.S.: Radioimmunoassay in gastroenterology. Gastroenterology 62, 1061–1084(1972).PubMedGoogle Scholar
  6. Berson, S.A., Walsh, J.H., Yalow, R.S.: Radioimmunoassay of gastrin in human plasma and regulation of gastrin secretion. In: Andersson, S. (ed.), Frontiers in gastrointestinal hormone research. Stockholm: Almquist und Wiksell 1972.Google Scholar
  7. Bloom, S.R.: Hormones of the gastrointestinal tract. Brit. med. Bull. 30, 62–67 (1974a).PubMedGoogle Scholar
  8. Bloom, S.R.: Endogenous release of secretin and cholecystokinin under physiological and pathophysiological conditions. V. World Congress of Gastroenterology, Mexico 1974b.Google Scholar
  9. Bloom, S.R., Ward, A.S.: Failure of secretin release in patients with duodenal ulcer. Brit. Med. J. 1975/I, 126–127.Google Scholar
  10. Boden, G., Chey, W.Y.: Preparation and specificity of antiserum to synthetic secretin and its use in a radioimmunoassay. Endocrinology 92, 1617–1624 (1973).PubMedGoogle Scholar
  11. Bonfils, S., Bader, J.-P., Dusbrasquet, M., Lambling, A.: Test biologique explorant les facteurs gastro-sécrétagogue en cours du syndrome du Zollinger-Ellison. Arch. Mal. Appar. dig. 54, 647–662(1965).PubMedGoogle Scholar
  12. Buchanan, K.D., Teale, J.D., Harper, G.: Antibodies to unconjugated synthetic and natural secretin (Abstr.). Horm. Metab. Res. 4, 507 (1972).PubMedGoogle Scholar
  13. Buchanan, K.D., Elmore, D.T.: Enzymatic iodination of the histidyl residue of secretin: A radioimmunoassay of the hormone. Biochim. biophys. Acta 322, 178–180 (1973).PubMedGoogle Scholar
  14. Byrnes, D.J., Coleman, M.J., Lazarus, L.: Radioimmunoassay of serum gastrin in patients with peptic ulceration using antiserum against pentagastrin. In: Demling, L. (ed.), Gastrointestinal hormones. Stuttgart: Thieme 1972.Google Scholar
  15. Chisholm, D.J., Young, J.D., Lazarus, L.: The gastrointestinal stimulus to insulin release. I. Secretin. J. Clin. Invest. 48, 1453–1460 (1969).PubMedGoogle Scholar
  16. Chisholm, D.J., Lazarus, L., Young, J.D.: Abnormalities of serum secretin in diabetes mellitus. Diabetes 19, 365 (1970).Google Scholar
  17. Chisholm, D.J., Kraegen, E.W., Young, J.D.: Comparison of secretin response to oral intraduodenal or intravenous glucose administration. Hormone Metab. Res. 3, 180–183 (1971).Google Scholar
  18. Cleator, I.G.M., Thomson, C.G., Sircus, W., Coombs, M.: Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of choleric diarrhoea. Gut 11, 206–211 (1970).PubMedGoogle Scholar
  19. DiMagno, E.P., Go, V.L.W., Summerskill, W.H.J.: Pancreozymin secretion is impaired in sprue (Abstr.). Gastroenterology.Google Scholar
  20. Dörner, M., Lackas, S., Kaess, H.: Plasmagastrinkonzentration bei Normalpersonen sowie bei Patienten mit Erkrankungen des Magens, der Leber, der Nieren und des Pankreas. Verh. Dtsch. Ges. Inn. Med. 78, 1409–1411 (1972).PubMedGoogle Scholar
  21. Eisen, H.N., Siskind, G.W.: Variations in affinities of antibodies during the immune response. Biochemistry 3, 996–1008 (1964).PubMedGoogle Scholar
  22. Emås, S., Fyrö, B.: Antral gastrin activity in duodenal and gastric ulcers. Gastroenterology 46, 1–7(1964).Google Scholar
  23. Englert, E., Jr.: Radioimmunoassay (RIA) of cholecystokinin (CCK). Clin. Res. 21, 297 (1973).Google Scholar
  24. Feurle, G., Ketterer, H., Creutzfeldt, W.: Erfahrungen mit einem Radioimmunoassay für Gastrin. Verh. Dtsch. Ges. Inn. Med. 76, 965–968 (1970).Google Scholar
  25. Feurle, G., Ketterer, H., Becker, H.D., Creutzfeldt, W.: Circadian serum gastrin concentrations in control persons and in patients with ulcer disease. Scand. J. Gastroent. 7, 177–183 (1972).PubMedGoogle Scholar
  26. Fordtran, J.S., Walsh, J.H.: Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. J. clin. Invest. 52, 645–657 (1973).PubMedGoogle Scholar
  27. Fritsch, W.-P., Hausamen, T.-U., Rick, W.: Beziehungen der Serumgastrinkonzentration zur Funktion und Histologie der Magenschleimhaut. Verh. Dtsch. Ges. Inn. Med. 77, 507 (1971).PubMedGoogle Scholar
  28. Fritsch, W.-P., Müller, J., Rick, W., Hausamen, T.-U.: Serum-Gastrinspiegel und Magensekretion bei Patienten mit Ulcus pepticum. Dtsch. Med. Wschr. 97, 1945–1950 (1972).PubMedGoogle Scholar
  29. Fritsch, W.-P.: Die klinische Bedeutung der Serumgastrinbestimmung bei der Ulcuskrankheit. Habilitationsschrift, Düsseldorf 1975.Google Scholar
  30. Ganguli, P.C., Hunter, W.M.: Iodination of gastrin. In: Radioimmunoassay methods. Kirkham, K.E., Hunter, W.M. (eds.). Edinburgh-London: Churchill, Livingstone 1971.Google Scholar
  31. Ganguli, P.C., Cullen, D.R., Irvine, W.J.: Radioimmunoassay of plasma-gastrin in pernicious anaemia, achlorhydria without pernicious anaemia, hypochlorhydria, and in controls. Lancet 1971/I,155–158.Google Scholar
  32. Glass, J.D., Schwartz, I.L., Walter, R.: Enzymatic inactivation of peptide hormones possessing a C-terminal amide group. Proc. Natl. Acad. Sci. U.S.A. 63, 1426–1430 (1969).PubMedGoogle Scholar
  33. Go, V.L.W., Ryan, R.J., Summerskill, W.H.J.: Radioimmunoassay of porcine cholecystokinin-pancreozymin. J. Lab. Clin. Med. 77, 684–689 (1971).PubMedGoogle Scholar
  34. Goodfriend, T.L., Levine, L., Fasman, G.D.: Antibodies to bradykinin and angiotensin: a use of carbodiimides in immunology. Science 144, 1344–1346 (1964).PubMedGoogle Scholar
  35. Gregory, R.A., Tracy, H.J.: Constitution and properties of two gastrins extracted from hog antral mucosa. Gut 5, 103–114 (1964).PubMedGoogle Scholar
  36. Haber, E., Richards, F.F., Spragg, J., Austen, K.F., Vallotton, M., Page, L.B.: Modifications in the heterogeneity of the antibody response. In: Frisch, L., Cairus, J. (Eds.), Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor, L.J. Vol. 32. New York: Cold Spring Harbor Laboratory of Quantitative Biology 1967.Google Scholar
  37. Halter, F., Smith, G.M.: The biological assay of gastrin. Acta Hepato-Gastroenterol. 19, 25–29 (1972).Google Scholar
  38. Hansky, J., Cain, M.D.: Radioimmunoassay of gastrin in human serum. Lancet 1969/II,1388–1390.Google Scholar
  39. Hansky, J., Korman, M.G.: Immunoassay studies in peptic ulcer. In: Sircus, W. (ed.), Clinics in Gastroenterology. Vol. 2: Peptic ulceration. London: Saunders 1973.Google Scholar
  40. Harvey, R.F., Hartog, M., Dowsett, L., Read, A.E.: A radioimmunoassay for cholecystokinin-pancreozymin. Lancet 1973/II, 826–828.Google Scholar
  41. Haurowitz, F.: Studies on the structure and formation of antibodies. In: Westphal, O., Bock, H.E. (eds.): Current problems in immunology (Bayer Symposium I). Berlin, Heidelberg, New York: Springer 1969.Google Scholar
  42. Hausamen, T.-U., Fritsch, W.-P.: Zur Physiologie und Pathophysiologie des Gastrins. Klin. Wschr. 51, 937–950(1973).PubMedGoogle Scholar
  43. Holohan, K.N., Murphy, R.F., Buchanan, K.D., Elmore, D.T.: Enzymatic iodination of polypeptide hormones for radioimmunoassay. Clin. chim. Acta 45, 153–157 (1973).PubMedGoogle Scholar
  44. Hunter, W.M.: The preparation and assessment of iodinated antigen. In: Kirkham, K.E., Hunter, W.M. (eds.): Radioimmunoassay methods. Edinburgh, London: Churchill, Livingstone 1971.Google Scholar
  45. Hunter, W.M., Greenwood, F.C.: Preparation of 131J iodine labeled human growth hormone of high specific activity. Nature (Lond.) 194, 495–496 (1962).Google Scholar
  46. Isenberg, J.I., Walsh, J.H., Passaro, E., Jr.: Unusual effect of secretin on serum gastrin, serum calcium, and gastric acid secretion in a patient with suspected Zollinger-Ellison syndrome. Gastroenterology 62, 626–631 (1972).PubMedGoogle Scholar
  47. Ingram, G., Herring, D.W., Venables, C.W., Blair, E.L.: Plasma gastrin activity in patients with recurrent peptic ulceration (abstr.). Brit. J. Surg. 58, 298–299 (1971).PubMedGoogle Scholar
  48. Jeffcoate, S.C.: Radioimmunoassay of gastrin: specificity of antisera. Scand. J. Gastroenterol. 5, 457–461 (1969).Google Scholar
  49. Johnson, A.G., McDermott, S.J.: Sensitive bioassay of cholecystokinin in human serum. Lancet 1973/II,589–591.Google Scholar
  50. Ketterer, H., Arnold, R., Becker, H.D., Creutzfeldt, C., Feurle, G., Creutzfeldt, W.: Circadian serum gastrin concentration and G-cells in the antral mucosa in control persons and in patients with ulcer disease (abstr.) Biologie et Gastro-Entérologie 5, 445 (1972).Google Scholar
  51. Korman, M.G., Soveny, C., Hansky, J.: Serum gastrin in duodenal ulcer. Gut 12, 899–902 (1971).PubMedGoogle Scholar
  52. Korman, M.G., Soveny, C., Hansky, J.: The effect of glucagon in serum gastrin. II. Studies in pernicious anaemia and the Zollinger-Ellison syndrome. Gut 14, 459–461 (1973).PubMedGoogle Scholar
  53. Lai, K.: Studies on gastrin. Gut 5, 327–333 (1964).PubMedGoogle Scholar
  54. Lomsky, R.F., Langr, F., Vortel, V.: Immunhistochemical demonstration of gastrin in mammaliam islets of Langerhans. Nature 223, 618–619 (1969).PubMedGoogle Scholar
  55. McGuigan, J.E.: Antibodies to the carboxylterminal tetrapeptide of gastrin. Gastroenterology 53, 697–705 (1967).PubMedGoogle Scholar
  56. McGuigan, J.E.: Immunochemical studies with synthetic human gastrin. Gastroenterology 54, 1005 – 1011 (1968a).PubMedGoogle Scholar
  57. McGuigan, J.E.: Antibodies to the C-terminal tetrapeptide amide of gastrin: assessment of antibody binding to cholecystokinin-pancreozymin. Gastroenterology 54, 1012–1017 (1968 b).PubMedGoogle Scholar
  58. McGuigan, J.E.: Gastric mucosal intracellular localization of gastrin by immunofluorescence. Gastroenterology 55, 315–327 (1968c).PubMedGoogle Scholar
  59. McGuigan, J.E.: Studies of the immunochemical specificity of some antibodies to human gastrin I. Gastroenterology 56, 429–438 (1969).PubMedGoogle Scholar
  60. McGuigan, J.E.: Production and characterization of specific antibodies to gastrin with no cross-reactivity with cholecystokinin-pancreozymin. Amer. J. Med. Sci. 260, 139–149 (1970).PubMedGoogle Scholar
  61. McGuigan, J.E., Thomas, H.F.: Physiological and immunological studies with desamidogastrin. Gastroenterology 62, 553–558 (1972).PubMedGoogle Scholar
  62. Müller, J., Fritsch, W.-P., Rick, W., Hausamen, T.-U.: Unveröffentlichte Befunde (1972).Google Scholar
  63. Mutt, V., Jorpes, J.E.: Isolation of aspartyl-phenylalanine amide from cholecystokinin-pancreozy-min. Biochem. Biophys. Res. Comm. 26, 392–397 (1967).PubMedGoogle Scholar
  64. Nilsson, G., Yalow, R.S., Berson, S.A.: Distribution of gastrin in the gastrointestinal tract of human, dog, cat and hog. In: Andersson, S. (ed.), Frontiers in gastrointestinal hormone research. Stockholm: Almquist und Wiksell 1972.Google Scholar
  65. Odell, W.D., Rayford, P.L., Ross, G.T.: Simplified, partially automated method for radioimmunoassay of human thyroid-stimulating, growth, luteinizing and follicle — stimulating hormones. J. Lab. clin. Med. 70, 973–980 (1967).PubMedGoogle Scholar
  66. Odell, W.D., Charters, A.C., Davidson, W.D., Thompson, J.C.: Radioimmunoassay for human gastrin using unconjugated gastrin as anantigen J. Clin. Endocrin. Metabolism 28, 1840–1842 (1968).Google Scholar
  67. Passaro, E., Basso, N., Walsh, J.H.: Calcium challenge in the Zollinger-Ellison syndrome. Surgery 72, 60–67(1972).PubMedGoogle Scholar
  68. Polak, J.M., Coulling, I., Bloom, S., Pearse, A.G.E.: Immunofluorescent localization of secretin and enteroglucagon in human intestinal mucosa. Scand. J. Gastroenterology 6, 739–744 (1971).Google Scholar
  69. Prescott, R.J.: Discussion on mathematical treatment on data. In: Kirkham, K.E., Hunter, W.M. (eds.): Radioimmunoassay methods. Edinburgh, London: Churchill, Livingstone 1971.Google Scholar
  70. Reeder, D.D., Jackson, B.M., Ban, J.L., Davidson, W.D., Thompson, J.C.: Effect of food on serum gastrin concentrations in duodenal ulcer and control patients. Surg. Forum 21, 290–291 (1970).PubMedGoogle Scholar
  71. Reeder, D.D., Becker, H.D., Smith, N.J., Rayford, P.L., Thompson, J.C.: Measurement of endogenous release of cholecystokinin by radioimmunoassay. Ann. Surg. 178, 304–310 (1973).PubMedGoogle Scholar
  72. Rehfeld, J.F., Stadil, F., Rubin, B.: Produktion and evaluation of antibodies for the radioimmunoassay of gastrin. Scand. J. Clin. Lab. Invest. 30, 221–232 (1972).PubMedGoogle Scholar
  73. Rodbard, D., Ruder, H.J., Vaitukaitis, J., Jacobs, H.S.: Mathematical analysis of kinetics of radioligand assays: Improved sensitivity obtained by delayed addition of labeled ligand. J. clin. Endocr. 33, 343–355 (1971).PubMedGoogle Scholar
  74. Schneider, D.R., Endahl, G.L., Dodd, M.C., Jesseph, J.E., Bigley, N.J., Zollinger, J.N.: Gastrin antibodies: induction, demonstration and specificity. Science 156, 391–392(1967).PubMedGoogle Scholar
  75. Scholten, T., Schönrock, K., Fritsch, W.-P., Hausamen, T.-U.: Unveröffentlichte Befunde (1974).Google Scholar
  76. Smith, G.M., Lawrence, A.J., Colin-Jones, D.G., Schild, H.O.: The assay of gastrin using the perfused rat stomach. Brit. J. Pharmacol. 38, 206–213 (1970).Google Scholar
  77. Stadil, F.: Effect of vagotomy on gastrin release during insulin hypoglycaemia in ulcer patients. Scand. J. Gastroenterol. 7, 225–231 (1972).PubMedGoogle Scholar
  78. Stadil, F., Rehfeld, J.F.: Preparation of 125J-labeled synthetic human gastrin I for radioimmunoana-lysis. Scand. J. Lab. Clin. Invest. 30, 361–368 (1972).Google Scholar
  79. Stadil, F., Rehfeld, J.S.: Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand. J. Gastroenterol. 8, 101–112 (1973).PubMedGoogle Scholar
  80. Strempel, J.F., Abramoff, P., van Oss, C.J., Wilson, S.D., Ellison, E.H.: Antibodies to synthetic human gastrin I. Lancet 1967/II, 1180–1182.Google Scholar
  81. Svatos, A., Bartos, V.L., Brzek, V.: The concentration of cholecystokinin in human lymph and serum. Arch. int. Pharmacodyn. 149, 515–520 (1964).PubMedGoogle Scholar
  82. Temperley, J.M., Stagg, B.H.: Bioassay and radioimmunoassay of plasma gastrin in a case of Zollinger-Ellison-syndrome. Scand. J. Gastroenterol. 6, 735–738(1971).PubMedGoogle Scholar
  83. Thompson, J.C., Reeder, D.D., Buchanan, H.H.: Clinical role of serum gastrin measurements in the Zollinger-Ellison syndrome. Amer. J. Surg. 124, 250–260 (1972).PubMedGoogle Scholar
  84. Trout, H.H., Walsh, J.H., Grossman, M.I.: Immunochemical versus biological potency of gastrin from different species (abstr.). Gastroenterology 60, 807 (1971).Google Scholar
  85. Trudeau, W.L., McGuigan, J.E.: Serum gastrin levels in patients with peptic ulcer disease. Gastroenterology 59, 6–12 (1970).PubMedGoogle Scholar
  86. Trudeau, W.L., McGuigan, J.E.: Relations between serum gastrin levels and rates of gastrin hydrochloric acid secretion. New. Engl. J. Med. 284, 408–412 (1971).PubMedGoogle Scholar
  87. Wadell, W.R., Lythgoe, J.P., Monaco, A.P.: Immunological studies of gastrin. Science 134, 2099–2100(1961).Google Scholar
  88. Walsh, J.H., Csendes, M.D., Grossman, M.L.: Truncal vagotomy on gastrin release and Heidenhain pouch acid secretion in response to feeding. Gastroenterology 63, 593–600 (1972).PubMedGoogle Scholar
  89. Yalow, R.S., Berson, S.A.: Assay of plasma insulin in human subject by immunological methods. Nature 184, 1648–1650 (1959).PubMedGoogle Scholar
  90. Yalow, R.S., Berson, S.A.: Radioimmunoassay of gastrin. Gastroenterology 58, 1–14 (1970a).PubMedGoogle Scholar
  91. Yalow, R.S., Berson, S.A.: Size and charge distinction between endogenous human plasma gastrin in peripheral blood and heptadecapeptide gastrins. Gastroenterology 58, 609–615 (1970b).PubMedGoogle Scholar
  92. Yalow, R.S., Berson, S.A.: Further studies on the nature of immunoreactive gastrin in human plasma. Gastroenterology 60, 203–214 (1971).PubMedGoogle Scholar
  93. Yalow, R.S., Berson, S.A.: And now „big, big“gastrin. Biochem. Biophys. Res. Comm. 48, 391–395 (1972).PubMedGoogle Scholar
  94. Young, J.D., Lazarus, L., Chrisholm, D.J.: Radioimmunoassay of pancreozymin-cholecystokinin in human serum. J. Nucl. Med. 10, 743–745 (1969 a).PubMedGoogle Scholar
  95. Young, J.D., Lazarus, L., Chrisholm, D.J.: Radioimmunoassay of secretin in human serum. J. Nucl. Med. 9, 641–642 (1969b).Google Scholar
  96. Young, J.D., Byrnes, D.J., Chrisholm, D.J., Griffiths, F.B., Lazarus, L.: Radioimmunoassay of gastrin in human serum using antiserum against pentagastrin. J. Nucl. Med. 10, 746–748 (1969c).PubMedGoogle Scholar

Literatur

  1. Hadorn, B., Johansen, P.G., Anderson, C.M.: Pancreozymin secretin test of exocrine pancreatic function in cystic fibrosis and the significance of the result for the pathogenesis of the disease. Can. Med. Ass. J. 98, 377–385 (1968).PubMedGoogle Scholar
  2. Hartley, R.C., Gambill, E.E., Engstrom, G.W., Summerskill, W.H.J.: Pancreatic exocrine function. Amer. J. Dig. Dis. 11, 27–39 (1966).PubMedGoogle Scholar
  3. Lagerlöf, H.O.: Pancreatic function and pancreatic disease, studied by means of secretin. Acta med. Scand. Suppl. 128, 1–289 (1942).Google Scholar
  4. Natelson, S.: Microtechniques of clinical chemistry. 2nd ed., Springfield, Ill.: Charles C. Thomas 1961.Google Scholar
  5. Ohlsén, P.: Endocrine and exocrine pancreatic function in pancreatitis. Acta med. Scand. Suppl. 484, 1–99 (1968).PubMedGoogle Scholar
  6. Ribet, A., Pascal, J.-P.: Le Pancréas exocrine. Paris: Masson et Cie 1968.Google Scholar
  7. Rick, W.: Der Secretin-Pankreozymin-Test in der Diagnostik der Pankreasinsuffizienz. Internist 11,110–117(1970).PubMedGoogle Scholar
  8. Sarles, H., Salem, E., Cros, R.Ch., Figarella, C.: Exploration pancréatique par tubage. Acta gastro-ent. belg. 33, 303–318 (1970).Google Scholar
  9. Slyke, D.D. van, Neill, J.M.: The determination of gases in blood and other solutions by vacuum extraction and manometric measurement. J. biol. Chem. 61, 523–573 (1924).Google Scholar
  10. Wormsley, K.G.: Response to secretin in man. Gastroenterology 54, 197–209 (1968).PubMedGoogle Scholar

Literatur

  1. Babson, A.L., Williams, P.A.R., Phillips, G.E.: An evaluation of serum „trypsin“tests. Clin. Chem. 8, 62 (1962).PubMedGoogle Scholar
  2. Barrett, A.J., Starkey, P.M.: The interaction of α2-makroglobulin with proteinases. Biochem. J. 133, 709–724(1973).PubMedGoogle Scholar
  3. Beck, J.T., Pinter, E., Solymar, J., McKenna, R.D., Ritchie, A.C.: The role of pancreatic enzymes in the pathogenesis of acute pancreatitis. II. The fate of pancreatic proteolytic enzymes in the course of acute pancreatitis. Gastroenterology 43, 60–70 (1962).PubMedGoogle Scholar
  4. Creutzfeldt, W., Schmidt, H.: Aetiologie and pathogenesis of pancreatitis (current concepts). Scand. J. Gastroent. Suppl. 6, Vol. 5, 47–62 (1970).Google Scholar
  5. Floch, M.H., Groisser, V.W.: Serum proteolytic enzyme activity in pancreatic disease. New Engl. J. Med. 263, 1129(1960).PubMedGoogle Scholar
  6. Geokas, M.C., Rinderknecht, A., Swanson, V., Haverback, B.J.: The role of elastase in acute hemorrhagic pancreatitis in man. J. Lab. Invest. 19, 235–239 (1968).Google Scholar
  7. Gjone, E., Ofstad, E., Marton, P.F., Amundsen, E.: Phospholipase activity in pancreatic exudate in experimental acute pancreatitis. Scand. J. Gastroent. 2, 181–185 (1967).PubMedGoogle Scholar
  8. Harpel, P.C., Mosesson, M.W.: Degradation of human fibrinogen by plasma α2-makroglobulin-enzyme complexes. J. clin. Invest. 52, 2175–2184 (1973).PubMedGoogle Scholar
  9. Heimburger, N., Haupt, H., Schwick, H.G.: Proteinase inhibitors of human plasma. In: Proteinase Inhibitors, Fritz, H., Tschesche, H., Hrsg. S. 1–21. Berlin: De Gruyter 1971.Google Scholar
  10. Homer, G.M., Zipf, R.E., Hieber, T.E., Katchman, B.J.: The trypsin inhibitor capacity of serums in normal and diseased states. Amer. J. clin. Path. 34, 99–107 (1960).Google Scholar
  11. Jacobsson, K.: Electrophoretic demonstration of two trypsin inhibitors in human blood serum. Scand. J. clin. Lab. Invest. 5, 97–98 (1953).PubMedGoogle Scholar
  12. Jacobsson, K.: Studies on fibrinogen. II. Studies on the trypsin and plasmin inhibitors in human blood serum. Scand. J. clin. Lab. Invest. Suppl. 14, 55 (1955).Google Scholar
  13. Kazal, L.A., Spicer, D.S., Brahinsky, R.A.: Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas. J. Amer. Chem. Soc. 70, 3034–3040 (1948).Google Scholar
  14. Laurell, C.-B.: Antigen-antibody crossed electrophoresis. Anal. Biochem. 10, 358 (1965).PubMedGoogle Scholar
  15. Nardi, G.L.: Serum trypsin determination in pancreatic disease. J. Lab. clin. Med. 52, 66–69 (1958).PubMedGoogle Scholar
  16. Nardi, G.L.: Serum “trypsin” (or arginine exopeptidase) screening test for cancer of the pancreas. Gastroenterology 38, 50–51 (1960).PubMedGoogle Scholar
  17. Ofstad, E.: Formation and destruction of plasma kinins during experimental acute hemorrhagic pancreatitis in dogs. Scand. J. Gastroent. Suppl. 5 (1970).Google Scholar
  18. Ohlsson, K.: Interaction between plasma protease inhibitors and some proteolytic enzymes in vitro and in vivo. Akademisk avhandling Malmö 1971.Google Scholar
  19. Pfeffer, R.B., Stasior, O., Hinton, J.W.: The clinical picture of the sequential development of acute hemorrhagic pancreatitis in the dog. Surg. Forum 8, 248–251 (1957).PubMedGoogle Scholar
  20. Polya, E.: Die Wirkung des Trypsins auf das lebende Pankreas. Arch. Ges. Physiol. 121, 483–507 (1908).Google Scholar
  21. Schmidt, H., Creutzfeldt, W., Habermann, E.: Phospholipase A—ein möglicherweise entscheidender Faktor in der Pathogenese der akuten Pankreatitis. Klin. Wschr. 45, 163–164 (1967).PubMedGoogle Scholar
  22. Schultze, H.E., Göllner, J., Heide, H., Schönenberger, H., Schwick, H.G.: Zur Kenntnis der α-Globuline des menschlichen Normalserums. Z. Naturforschung 10b, 463–473 (1955).Google Scholar
  23. Schultze, H.E., Heide, K., Haupt, H.: α1-Antitrypsin aus Humanserum. Klin. Wschr. 40, 427–429 (1962).PubMedGoogle Scholar
  24. Storck, G.: Fat necrosis in acute pancreatitis. Morphological and chemical studies in the rat. Acta Chir. Scand. Suppl. 417, 22 (1971).Google Scholar

Literatur

  1. Adlersberg, D., Kann, S., Maurer, A.P., Newerly, K.R., Winternitz, W., Sobotka, H.: Studies on serum carotene in man. Amer. J. digest. Dis. 16, 333 (1949).Google Scholar
  2. Bessey, O.A., Lowry, O.H., Brock, M.J., Lopez, J.A.: The determination of vitamin A and carotin in small quantities of blood serum. J. biol. Chem. 166, 177 (1946).PubMedGoogle Scholar
  3. Bieri, J.G., Schultze, M.O.: Comments on the microspectrophotometric determination of vitamin A and carotene in blood. Arch. Biochem. Biophys. 33, 273 (1951).Google Scholar
  4. Carr, F.H., Price, E.A.: Colour reactions attributed to vitamin A. Biochem. J. 20, 497 (1926).PubMedGoogle Scholar
  5. Chesney, J., McCoord, A.B.: Vitamin A of serum following administration of haliver oil in normal children and in chronic steatorrhea. Proc. Soc. exp. Biol. N.Y. 31, 887 (1934).Google Scholar
  6. Craig, R.G., Bergquist, L.M., Searcy, R.L.: A new vitamin A colour reaction. Anal. Biochem. 1, 433 (1960).PubMedGoogle Scholar
  7. Deuel, H.J.: The Lipids Vol. I. Publishers New York: Interscience 1955.Google Scholar
  8. Dost, F.H., Rind, H.: Kinetische Betrachtungen zum Vitamin A-Serumspiegel nach Belastung. Int. Z. Vitamin-forsch. 27, 479 (1957).Google Scholar
  9. Feldman, E.B., Adlersberg, D.: Response to carotene loading in malabsorption states. Amer. J. med. Sci. 238, 733 (1957).Google Scholar
  10. Fitzgerald, O., Fennelly, J.J., Hingerty, D.J.: Serum studies in man after administration of vitamin A alcohol. Gut 2, 263 (1961) u. 3, 74 (1962).PubMedGoogle Scholar
  11. Hillman, R.W., Becker, N.H.: Absorption of ingested vitamin A. Gastroenterology 32, 738 (1957).PubMedGoogle Scholar
  12. Kahan, J.: The vitamin A absorption test. I. Studies on children and adults without disorders in the alimentary tract. Scand. J. Gastroent. 4, 313 (1969).PubMedGoogle Scholar
  13. Kahan, J.: Studies on the vitamin A absorption test. Opusc, med. (Stockh.) Supp. XIV OPMSA (1970).Google Scholar
  14. Kasper, H.: Vitaminresorption nach Pankreatektomie. Gastroenterologia 107, 305 (1967).PubMedGoogle Scholar
  15. Kasper, H.: Die Vitamin A-und Carotinkonzentration im Serum: I. Bei optimal ernährten Personen in Westdeutschland. Int. Z. Vitamin-Forsch. 38, 142 (1968).Google Scholar
  16. Kasper, H.: Untersuchungen nach intravenöser Injektion von Vitamin A-Palmitat. Int. Z. Vitaminforsch. 39, 13 (1969).PubMedGoogle Scholar
  17. Kasper, H., Ernst, B.: Der Einfluß des Nahrungsfettes auf die Vitamin A-und Carotinresorption. Int. Z. Vitamin-forsch. 39, 23 (1969).Google Scholar
  18. Kasper, H., Krennrich, O.: Der Einfluß von Phosphatiden auf den Stoffwechsel von Vitamin A und Carotin. Z. ges. exp. Med. 139, 644 (1965).Google Scholar
  19. Kasper, H., Krennrich, O.: Methodische Verbesserungen bei der Durchführung des Leberspeichertestes (Vitamin A) nach Guggenheim und Koch. Zsch. Versuchstierk. 6, 71 (1965).Google Scholar
  20. Mahadevan, S., Seshadri Sastry, P., Ganguly, J.: Studies on metabolism of vitamin A. Biochem. J. 88, 531(1963).PubMedGoogle Scholar
  21. Mendeloff, A.J.: The effect of eating and of sham feeding upon the absorption of vitamin A palmitate in man. J. clin. Invest. 33, 1015 (1954).PubMedGoogle Scholar
  22. Moore, T.: Vitamin A. Amsterdam-London-New York: Elsevier Publishing Company 1957.Google Scholar
  23. Murill, W.A., Horton, P.B., Leiberman, E., Newburgh, L.H.: Vitamin A and Carotene. J. clin. Invest. 20, 395 (1941).Google Scholar
  24. Neeld, J.B., Pearson, W.N.: Macro-and micromethods for the determination of vitamin A using trifluoracetic acid. J. Nutr. 79, 454 (1963).PubMedGoogle Scholar
  25. Onstad, G.R., Zieve, L.: Carotene absorption. A screenming test for steatorrhea. J. Amer. Med. Ass. 221, 677 (1972).Google Scholar
  26. Ross, G., Parker, J.G.: Serum carotene concentration in normal individuals and its clinical interpretation. N.Y. St. J. Med. 62, 3584 (1962).Google Scholar
  27. Schjoth, A.E.: The effect of physical activity on the vitamin A absorption test. Scand. J. clin. Lab. Invest. 17, 275 (1965).PubMedGoogle Scholar
  28. Sobel, A.E., Werbin, H.: A spectrophotometric study of a new colorimetric reaction of vitamin A. J. biol. Chem. 159, 681 (1945).Google Scholar
  29. Strohecker, R., Henning, H.M.: Vitaminbestimmungen. Weinheim: Verlag Chemie 1963.Google Scholar
  30. Wenger, J., Kirsner, J.B., Palmer, W.L.: Blood carotene in steatorrhea and the malabsorptive syndromes. Amer. J. Med. 22, 373 (1951).Google Scholar
  31. Wormsley, K.G.: Use of labelled triolein, vitamin A, and D-xylose in the diagnosis of malabsorption. Gut 4, 261 (1963).PubMedGoogle Scholar

References

  1. Anderson, M.C., Toronto, L.R., Needleman, S.B., GramAtica, L.: Assessment of methemalbumin as a diagnostic test for acute pancreatitis. Arch. Surg. 98, 776–780(1969).PubMedGoogle Scholar
  2. Battersby, C., Green, M.K.: The surgical significance of methemalbuminemia. Gut 12, 995–1000 (1971).PubMedGoogle Scholar
  3. Chong, G.C., Owen, J.A.: Determination of methemalbumin in plasma. J. clin. Path. 20, 211–212 (1967).PubMedGoogle Scholar
  4. Edmondson, H.A., Berne, C.J., Homann, R.E., Wertman, M.: Calcium, potassium, magnesium and amylase disturbances in acute pancreatitis. Amer. J. Med. 12, 34–42 (1952).PubMedGoogle Scholar
  5. Fairley, N.H.: Methemalbumin. Clinical aspects. Quart. J. Med. 10, 95–114 (1941).Google Scholar
  6. Frey, C.F., Bradley, D.M., Clore, J., Wanner, J.: Hematin formation and pancreatitis. J. Surg. Res. 9, 73–78 (1969).PubMedGoogle Scholar
  7. Geokas, M.C., Weissman, R.A., Walberg, C.B., Pincus, I.J.: Serum methemalbumin in acute pancreatitis (abstract). Gastroenterology 56, 1161 (1969).Google Scholar
  8. Joseph, W.L., Stevens, G.H., Longmire, W.P., Jr.: Methemalbumin in the diagnosis of acute pancreatitis. J. Surg. Res. 8, 206–210 (1968).PubMedGoogle Scholar
  9. Kelly, T.R., Klein, R.L., Porquez, J.M., Homer, G.M.: Methemalbumin in acute pancreatitis: An experimental and clinical appraisal. Ann. Surg. 175, 15–18 (1972).PubMedGoogle Scholar
  10. Northam, B.E., Rowe, D.S., Winstone, N.E.: Methemalbumin in the differential diagnosis of acute hemorrhagic and edematous pancreatitis. Lancet 1963I, 348–351.Google Scholar
  11. Nyman, M., Gydell, K., Nosslin, B.: Haptoglobin und Erythrokinetik. Clin. chim. Acta 4, 82–87 (1959).PubMedGoogle Scholar
  12. Richardson, R.W., Glick, S., Bates, A., Shinton, N.K.: Methemalbumin in the diagnosis of pancreatitis. Lancet 1963 I, 608–609.Google Scholar
  13. Shinowara, G.Y. and Walters, M.I.: Hematin studies on protein complexes and determination in human plasma. Amer. J. clin. Path. 40, 113–122 (1963).Google Scholar
  14. Walberg, C.B., Geokas, M.C. and Rinderknecht, H.: Determination of serum methemalbumin. Clin. chim. Acta 48, 229–232 (1973).PubMedGoogle Scholar
  15. Winstone, N.E.: Methemalbumin in acute pancreatitis. Brit. J. Surg. 52, 804–808 (1965).PubMedGoogle Scholar

Literatur

  1. Ammann, R.: Fortschritte in der Pankreasfunktionsdiagnostik. Berlin-Heidelberg-New York: Springer 1967.Google Scholar
  2. Appels, A., Stephan, F., Hoffmann, G., Keiderling, W., Creutzfeldt, W.: Der J-l31-Triolein Test in der klinischen Diagnostik. W. Keiderling: Beiträge zur Inneren Medizin S. 469–476. Stuttgart: Schattauer 1964.Google Scholar
  3. Braddock, L.I., Fleisher, D.R., Barbaro, G.J.: A Physical chemical Study of the van de Kamer Method for Fecal fat Analysis. Gastroenterology 55, 165–172 (1968).PubMedGoogle Scholar
  4. Dawson, A.M.: Absorption of Fats. Brit. med. Bull. 23, 247–251 (1967).PubMedGoogle Scholar
  5. Haverback, B.J., Dyce, B.J., Gutentag, P.J., Montgomery, D.W.: Measurement of trypsin and Chymotrypsin in stool. A Diagnostik Test of Pancreatic Exocrine Insufficiency. Gastroenterology 44, 588–597(1963).Google Scholar
  6. Jeffries, G.H., Weser, E., Sleisenger, M.H.: Malabsorption. Gastroenterologie 56, 777–797 (1969).Google Scholar
  7. Kamer, J.H. van de, Bokkel Hunink, H. ten Weijers, H.A.: A rapid method for dermination of fat in faeces. J. biol, Chem. 177, 347–355 (1949).Google Scholar
  8. Kamer, J.H., van D.E.: Quantitative dermination of the saturated and unsaturated higher fatty acids in fecal fat. Scand. J. clin. Lab. Invest. 5, 30–36 (1953).Google Scholar
  9. Kasper, H.: Faecal fat Excretion, Diarrhea and subjective complaints with Highly Dosed Oral Fat Intake. Digestion 3, 321–330 (1970).PubMedGoogle Scholar
  10. Marks, I.N., Bank, S., Airth, E.: Pancreatic replacement therapy in the treatment of pancreatic steatorrhoea. Gut 4, 217–222(1963).PubMedGoogle Scholar
  11. Roy, A.D., Campbell, R., Biol, L.I., Goldberg, D.M.: Effect of diet on the trypsin and chymotrypsin output in the stools of patients with an ilesotomy. Gastroenterology 53, 584–589 (1967).PubMedGoogle Scholar
  12. Shils, M.E.: The esophagus, the vagi and fat absorption. Surg. Gynec. Obstet. 132, 709–715 (1971).PubMedGoogle Scholar
  13. Siede, W., Erb, W.: Untersuchungen über die Fettverdauungsstörung bei Pankreasinsuffizienz. Verh. dtsch. Ges. inn. Med. 78, 1418–1420 (1972).PubMedGoogle Scholar
  14. Smith, J.S., Ediss, I., Mullinger, M.A., Bogoch, A.: Fecal chymotrypsin and trypsin determinations. Canad. Med. Ass. J 104, 691–697 (1971).PubMedGoogle Scholar
  15. Stanley, M.M., Thanhauser, S.J.: The Apsorption and Disposition of orally administrated J 131-labelled neutral fat in man: J. lab. clin. Med. 34, 1634–1639 (1949).Google Scholar
  16. Weijers, H.A., Kamer, J.H. van de: Coeliac Disease, I. Criticism of the Various of Investigation. Acta paediat. 42, 24–33 (1953).Google Scholar
  17. Wolochow, D.A., Brottmann, S.A., Williams, L.A., Zamcheck, N.: A rapid method for quantitative determination of fecal fat based on the principle of electric capacitance. J. lab. clin. Med. 65, 334–341 (1965).PubMedGoogle Scholar

Literatur

  1. Buchanan, D.J., Rapoport, S.: Chemical comparison of normal meconium and meconium from a patient with meconium ileus. Pediatrics 9, 304–309 (1952).PubMedGoogle Scholar
  2. Busch, R.: Zur Erfassung der Mukoviszidose beim Neugeborenen. Kinderärztl. Praxis 39, 268–271 (1971).Google Scholar
  3. Cain, A.R.R., Deall, A.M., Noble, T.C.: Screening for cystic fibrosis by testing meconium for albumin. Arch. Dis. Childh. 47, 131–132 (1972).PubMedGoogle Scholar
  4. Green, M.M., Clarke, J.T., Shwachman, H.: Studies in cystic fibrosis of the pancreas: protein pattern in meconium ileus. Pediatrics 21, 635–641 (1958).PubMedGoogle Scholar
  5. Green, M.N., Shwachman, H.: Presumptive tests for cystic fibrosis based on serum protein in meconium. Pediatrics 41, 989–992 (1968).PubMedGoogle Scholar
  6. Rule, A.H., Baran, D.T., Shwachman, H.: Quantitative determination of water-soluble proteins in meconium. Pediatrics 45, 847–850 (1970).PubMedGoogle Scholar
  7. Schachter, H., Dixon, G.H.: A comparitative study of the proteins in normal meconium and in meconium ileus patients. Canad. J. Biochem. 43, 381–397 (1965).PubMedGoogle Scholar
  8. Schutt, W.H., Isles, T.E.: Protein in meconium from meconium ileus. Arch. Dis. Childh. 43, 178–181(1968).PubMedGoogle Scholar
  9. Stephan, I.L., Busch, W., Dannemann, R.: BM-Test Meconium- ein neuer Screening-Test zum Nachweis der Mukoviszidose beim Neugeborenen. Klin. Pädiatr. 186, 79–83 (1974).PubMedGoogle Scholar
  10. Tinschmann, P., Nüsser, C.: Total protein, albumin and immunoglobulin content in meconium of premature and full-term infants. 5th annual meeting of the European working group for cystic fibrosis, Verona 1974.Google Scholar
  11. Wiser, W.C., Beier, F.R.: Albumin in meconium of infants with cystic fibrosis: a preliminary report. Pediatrics 33, 115–119 (1964).PubMedGoogle Scholar

Literatur

  1. Anderson, C.M., Freeman, M.: Sweat test results in normal persons of different ages compared with families with fibrocystic disease of the pancreas. Arch. Dis. Childh. 35, 581–587 (1960).PubMedGoogle Scholar
  2. Barbero, G.J., Sibinga, M.S.: Elektrolyte abnormality in cystic fibrosis. Pediat. Clin. North Amer. 11, 983–1001 (1964).Google Scholar
  3. Di Sant-Agnese, P.A., Darling, R.C., Perera, G.A., Shea, E.: Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics 12, 549–563 (1953).Google Scholar
  4. Di Sant-Agnese, P.A., Talamo, R.C.: Pathogenesis and physiopathology of cystic fibrosis of the pancreas. N. Engl. J. Med. 277, 1287–1294, 1343–1352, 1399–1408 (1967).Google Scholar
  5. Di Sant-Agnese, P.A.: Letters to editor. J. Pediatr. 81, 196–197 (1972).Google Scholar
  6. Emrich, H.M., Stoll, E., Friolet, B., Colombo, J.P., Rossi, E., Richter, R.: Excretion of different substances in the sweat of children with cystic fibrosis. Mod. Probl. Pediat. 10, 58–73 (1958) u. Basel-New-York: Karger 1967.Google Scholar
  7. Gibson, C.E., Cooke, R.E.: A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing Pilocarpin by iontophoresis. Pediatrics 23, 545–549 (1959).PubMedGoogle Scholar
  8. Gibson, C.E.: Relability of sweat tests in the diagnosis of cystic fibrosis. Letter to the editor. J. Pediatr. 81, 193–195 (1972).PubMedGoogle Scholar
  9. Gluck, L.: A patch test for chloride in sweat as a simple screening method for detecting cystic fibrosis of the pancreas. Preliminary report. Pediatrics 23, 731–737 (1959).PubMedGoogle Scholar
  10. Gorvoy, J.D., Aes, H., Stein, M.C.: Hazard of induction of sweating in cystic fibrosis of pancreas. Pediatrics 25, 977–982 (1960).PubMedGoogle Scholar
  11. Hadorn, B., Johanson, P.G., Anderson, C.M.: Exocrine pancreas function in cystic fibrosis. In: Proc. of the 5th Internat. Cystic Fibrosis Conference, D. Lawson (Ed.) London, p. 5 b. Cystic Fibrosis Research Tr. (1969).Google Scholar
  12. Herold, W.: Schweißwiderstandsmessung bei Mukoviszidose mit einer einfachen Kapillarsonde. Mschr. Kinderheilk. 117, 626–628 (1969).PubMedGoogle Scholar
  13. Kaiser, D.: Excretion of proteins, bicarbonate and cations by single sweat gland of patients with cystic fibrosis. In: Fundamental Problems of Cystic Fibrosis and Related Diseases. Mangos, J.A., Talamo, R.C., Eds. p. 247. Symposia Specialists, Miami, Florida (1973).Google Scholar
  14. Kopito, L., Mahmoodien, A., Townley, R.R.W., Khaw, K.T., Shwachman, H.: Studies in cystic fibrosis analysis of nail clippings for sodium and potassium. N. Engl. J. Med. 272, 504–509 (1965).PubMedGoogle Scholar
  15. Kopito, L., Shwachman, H.: Studies in cystic fibrosis: Determination of sweat electrolytes in situ with direct reading electrodes. Pediatrics 43, 794–798 (1969).PubMedGoogle Scholar
  16. Lawson, D., Saggers, B.A., Chapman, M.J.: Screening for cystic fibrosis by measurement of unstimulated parotid aliva levels. Arch. Dis. Childh. 42, 689–690 (1967).PubMedGoogle Scholar
  17. Lobeck, A., Huebner, D.: Effect of age, sex and cystic fibrosis on the sodium and potassium content of human sweat. Pediatrics 30, 172–179 (1962).PubMedGoogle Scholar
  18. Mastella, G., Barbuto, G., Provolo, A., Sgarbossa, V., Mengoli, V.: The activity of exocrine pancreas in cystic fibrosis. A study on 125 C.F-patients and 82 control subjects. European working group for cystic fibrosis. 5th Annual Meeting, Verona, Italy (1974).Google Scholar
  19. Schulz, I., Ullrich, K.J., Frömter, E., Holzgreve, M., Frick, A.: Mikropunktion und elektrische Potentialmessung an Schweißdrüsen des Menschen. Pflügers Arch. ges. Physiol. 284, 360–372 (1965).Google Scholar
  20. Shwachman, H., Gahm, N.: Studies in cystic fibrosis of the pancreas. A simple test for the detection of excessive chloride on the skin. N. Engl. J. Med. 255, 999–1001 (1956).PubMedGoogle Scholar
  21. Shwachman, H., Antonowiez, J.: Sweat test in cystic fibrosis. Amer. N. Y. Acad. Sci. 93, 600–620 (1962).Google Scholar
  22. Shwachman, H., Dunham, R., Philipps, W.R.: Electrical conductivity of sweat. Pediatrics 32, 85–88(1963).PubMedGoogle Scholar

Literatur

  1. Aenishänslin, W.H., Kayasseh, L., Stalder, G.A.: Die Pankreasfunktionsprüfung mit dem Lundh-Test. Dtsch. med. Wschr. 98, 2192–2196 (1973).PubMedGoogle Scholar
  2. Ammann, R., Dyck, W., Rosenmund, H., Ben Avraham, R.: Bestimmung der Trypsin-und Chymo-trypsinaktivität im Stuhl. Eine sensible, spezifische Methode zum Nachweis der exokrinen Pan-kreasinsuffizienz. Klin. Wschr. 42, 553–555 (1964).PubMedGoogle Scholar
  3. Anastasi, A., Erspamer, V., Endean, R.: Isolation, and amino acid sequence of caerulein, the active decapeptide of the skin of Hyla caerulea. Arch. Biochem. Biophys. 125, 57–68 (1968).PubMedGoogle Scholar
  4. Bartelheimer, H.: Quantitative fraktionierte Pankreas-und Gallensaftuntersuchungen durch Anwendung einer dreiläufigen Doppelballonsonde. Dtsch. med. Wschr. 78, 993–995 (1953).PubMedGoogle Scholar
  5. Bayliss, W.M., Starling, E.H.: Mechanism of pancreatic secretion. J. Physiol. (Lond.) 28, 325–353 (1902).Google Scholar
  6. B’Hend, P., Hadorn, B., Haldemann, B., Kleeb, M., Lüthi, H.: Stimulation of pancreatic secretion in man by secretin snuff. Lancet 1973/I, 509–513.Google Scholar
  7. Bodanszky, M., Ondetti, M.A., Levine, S.D., Narayanan, V.L., von Saltza, M., Sheehan, J.T., Williams, N.J., Sabo, E.F.: Synthesis of a heptacosapeptide amide with the hormonal activity of secretin. Chemistry and Industry 42, 1757–1758 (1966).PubMedGoogle Scholar
  8. Bonfils, S., Gislon, J., Junien, J.L.: Premiers résultats de la céruléine dans l’exploration fonctionelle pancréatique chez l’homme. Acta gastro-ent. belg. 34, 26–33 (1971).Google Scholar
  9. Borgström, B., Dahlqvist, A., Lundh, G., Sjövall, J.: Studies of intestinal digestion and absorption in the human. J. clin. Invest. 36, 1521–1536 (1957).PubMedGoogle Scholar
  10. Burton, P., Evans, D.G., Harper, A.A., Howat, H.T., Scott, J.S., Oleesky, S., Varley, H.: A test of pancreatic function in man, based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut 1, 111–124 (1960).PubMedGoogle Scholar
  11. Cook, H.B., Lennard-Jones, J.E., Sherif, S.M., Wiggins, H.S.: Measurement of tryptic activity in intestinal juice as a diagnostic test of pancreatic disease. Gut 8, 408–414 (1967).PubMedGoogle Scholar
  12. Creutzfeldt, W.: Funktionsdiagnostik bei Erkrankungen des exokrinen Pankreas. Verh. Dtsch. Ges. inn. Med. 70, 781–801 (1964).PubMedGoogle Scholar
  13. Creutzfeldt, W., Widmann, R.: Untersuchungen über die Funktion des exokrinen Pankreas bei Leber-und Gallenwegserkrankungen mit Hilfe des Mecholyl-Äthertestes. Klin. Wschr. 34, 968–974(1956).PubMedGoogle Scholar
  14. Dietschy, J.M., Salomon, H.S., Siperstein, M.D.: Bile acid metabolism. I. Studies on the mechanism of intestinal transport. J. clin. Invest. 45, 832–846(1966).PubMedGoogle Scholar
  15. DiMagno, E.P., Go, V.L.W., Summerskill, W.H.J.: Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. New Engl. J. Med. 288, 813–815 (1973).PubMedGoogle Scholar
  16. Dreiling, D.A., Greenstein, A.: Pancreatic function in patients with Zollinger-Ellison syndrome. Amer. J. Gastroent. 58, 66–72 (1972).PubMedGoogle Scholar
  17. Dreiling, D.A., Greenstein, A.J., Bordalo, O.: The hypersecretory states of the pancreas. Amer. J. Gastroent. 59, 505–511 (1973).PubMedGoogle Scholar
  18. Dreiling, D.A., Janowitz, H.D.: The laboratory diagnosis of pancreatic disease: secretin test. Amer. J. Gastroent. 28, 268–275 (1957).PubMedGoogle Scholar
  19. Dyck, W.P.: Pancreatic hypersecretion in the Zollinger-Ellison syndrome. Gastroenterology 60, 90–95 (1971).PubMedGoogle Scholar
  20. Erspamer, V.: Progress report: Caerulein. Gut 11, 79–87 (1970).PubMedGoogle Scholar
  21. Erspamer, V., Anastasi, A.: Polypeptides active on plain muscle in the amphibian skin. In: Erdös, E.G., Back, N., Sicuteri, F. (eds.): Hypotensive peptides. S. 63–75. Berlin-Heidelberg-New York: Springer 1966.Google Scholar
  22. Ertan, A., Brooks, F.P., Ostrow, J.D., Arvan, D.A., Williams, C.N., Cerda, J.J.: Effect of jejunal amino acid perfusion and exogenous cholecystokinin on the exocrine pancreatic and biliary secretions in man. Gastroenterology 61, 686–692 (1971).PubMedGoogle Scholar
  23. Forell, M.M., Otte, M., Kohl, H.J., Lehnert, P., Stahlheber, H.P.: The influence of bile and pure bile salts on pancreatic secretion in man. Scand. J. Gastroent. 6, 261–266 (1971).PubMedGoogle Scholar
  24. Forell, M.M., Stahlheber, H.: Gallefluß und Pankreassekretion. Klin. Wschr. 44, 1184–1189 (1966).PubMedGoogle Scholar
  25. Forell, M.M., Stahlheber, H., Otte, M.: Erkrankungen der Verdauungsorgane und ihr Einfluß auf die Pankreassekretion. Dtsch. med. Wschr. 94, 1097–1101 (1969).PubMedGoogle Scholar
  26. Forell, M.M., Stahlheber, H., Scholz, F.: Galle als Reiz der Enzymsekretion des Pankreas. Dtsch. med. Wschr. 90, 1128–1132 (1965).PubMedGoogle Scholar
  27. Fröhlich, Ch., Locher, M., von Oldershausen, H.F.: Die Beeinflussung des exokrinen Pankreas durch die intravenöse Infusion einer Nährlösung. Klin. Wschr. 51, 1207–1209 (1973).PubMedGoogle Scholar
  28. Go, V.L.W., Hofmann, A.F., Summerskill, W.H.J.: Simultaneous measurements of total pancreatic, biliary, and gastric outputs in man using a perfusion technique. Gastroenterology 58, 321–328 (1970).PubMedGoogle Scholar
  29. Goebell, H., Bode, Ch., Martini, G.A.: Häufigkeit und Ausmaß der Funktionsstörung des exokrinen Pankreas bei chronischen Lebererkrankungen. In: Bartelheimer, H., Heisig, N. (Hrsg.): Aktuelle Gastroenterologie. S. 358–360. Stuttgart: Thieme 1968.Google Scholar
  30. Goebell, H., Horn, H.-D., Bode, Ch.: Primärer Hyperparathyreoidismus und exkretorische Pan-kreasfunktion. Verh. Dtsch. Ges. inn. Med. 73, 1094–1097 (1967).PubMedGoogle Scholar
  31. Goldberg, D.M., Sale, J.K., Wormsley, K.G.: Ratio of chymotrypsin to trypsin in human duodenal aspirate. Digestion 8, 101–109 (1973).PubMedGoogle Scholar
  32. Goldberg, D.M., Wormsley, K.G.: The interrelationsships of pancreatic enzymes in human duodenal aspirate. Gut 11, 859–866 (1970).PubMedGoogle Scholar
  33. Hadorn, B., Johansen, P.G., Anderson, C.M.: Pancreozymin secretin test of exocrine pancreatic function in cystic fibrosis and the significance of the result for the pathogenesis of the disease. Can. med. Ass. J. 98, 377–385 (1968).PubMedGoogle Scholar
  34. Harper, A.A., Raper, H.S.: Pancreozymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine. J. Physiol. (Lond.) 102, 115–125 (1943).Google Scholar
  35. Hartley, R.C., Gambill, E.E., Engstrom, G.W., Summerskill, W.H.J.: Pancreatic exocrine function. Amer. J. dig. Dis. 11, 27–39 (1966).PubMedGoogle Scholar
  36. Haverback, B.J., Dyce, B.J., Gutentag, Ph.J., Montgomery, D.W.: Measurement of trypsin and chymotrypsin in stool. A diagnostic test for pancreatic exocrine insufficiency. Gastroenterology 44, 588–597(1963).Google Scholar
  37. Ivy, A.C., Kloster, G., Lueth, H.C., Drewyer, G.E.: On the preparation of “cholecystokinin”. Amer. J. Physiol. 91, 336–344 (1929).Google Scholar
  38. Ivy, A.C., Oldberg, E.: Contraction and evacuation of gallbladder caused by a highly purified “secretin” preparation. Proc. Soc. exp. Biol. (N.Y.) 25, 113–115 (1927).Google Scholar
  39. Jorpes, J.E., Mutt, V.: Secretin and cholecystokinin (CCK). In: Secretin, cholecystokinin, pancreozymin and gastrin. Jorpes, J.E., Mutt, V. (eds.), Handbuch der exp. Pharmakologie Bd. 34, S. 1–179. Berlin-Heidelberg-New York: Springer 1973.Google Scholar
  40. Kayasseh, L., Stalder, G.A.: Zur Diagnostik der Pankreasinsuffizienz. Schweiz. Med. Wschr. 101, 1624–1628(1971).PubMedGoogle Scholar
  41. Lagerlöf, H.O.: Pancreatic function and pancreatic disease, studied by means of secretin. Acta med. Scand. Suppl. 128, 1–289 (1942).Google Scholar
  42. Lagerlöf, H.O., Schütz, H.B., Holmer, S.: A secretin test with high doses of secretin and correction for incomplete recovery of duodenal juice. Gastroenterology 52, 67–77 (1967).PubMedGoogle Scholar
  43. Levin, G.E., Youngs, G.R., Bouchier, I.A.D.: Evaluation of the Lundh test in the diagnosis of pancreatic disease. J. clin. Path. 25, 129–132 (1972).PubMedGoogle Scholar
  44. Lundh, G.: Pancreatic exocrine function in neoplastic and inflammatory disease; a simple and reliable new test. Gastroenterology 42, 275–280 (1962).PubMedGoogle Scholar
  45. Malagelada, J.R., Go, V.L.W., DiMagno, E.P., Summerskill, W.H.J.: Interactions between intraluminal bile acids and digestive products on pancreatic and gallbladder function. J. clin. Invest. 52, 2160–2165(1973).PubMedGoogle Scholar
  46. Moeller, D.D., Dunn, G.D., Klotz, A.P.: Comparison of the pancreozymin-secretin test and the Lundh test meal. Amer. J. dig. Dis. 17, 799–805 (1972).PubMedGoogle Scholar
  47. Mutt, V., Jorpes, J.E.: Hormonal polypeptides of the upper intestine. Biochem. J. 125, 57P–58P (1971).PubMedGoogle Scholar
  48. Mutt, V., Magnusson, S., Jorpes, J.E., Dahl, E.: Structure of porcine secretin. I. Degradation with trypsin and thrombin. Sequence of the tryptic peptides. The C-terminal residue. Biochemistry 4, 2358–2362 (1965).Google Scholar
  49. Nundy, S., Shirley, D., Beales, J.S.M., O’Higgins, N., Heaf, R., Pearse, E.E., Lavender, J.P., Baron, J.H.: Simultaneous combined pancreatic test. Brit. med. J. 1974/I, 87–90.Google Scholar
  50. Otte, M., Stahlheber, H., Zoelch, M., Forell, M.M., Thurmayr, G.R., Thurmayr, R.: Pankreas-sekretion des Menschen nach Stimulation mit Cholecystokinin/Pankreozymin, Secretin und Galle. Klin. Wschr. 51, 915–920 (1973).PubMedGoogle Scholar
  51. Pointner, H.: Der Secretin-Pankreozymin-Test in der Funktionsdiagnostik des exokrinen Pankreas. Wiener klin. Wschr. 85, 665–667 (1973).Google Scholar
  52. Raskin, H.F., Wenger, L., Sklar, M., Pleticka, S., Yarema, W.: The diagnosis of cancer of the pancreas, biliary tracts and duodenum by combined cytologic and secretory methods. I. Exfoliative cytology and a description of a rapid method of duodenal intubation. Gastroenterology 34, 996–1008 (1958).PubMedGoogle Scholar
  53. Ribet, A., Pascal, J.-P.: Le Pancréas Exocrine. Paris: Masson et Cie 1968.Google Scholar
  54. Rick, W.: Zur Physiologie und Pathologie der Enzymsekretion des Pankreas. Habilitationsschrift Gießen 1963.Google Scholar
  55. Rick, W.: Zur Pathologie der Enzymsekretion des Pankreas. Acta gastro-ent. belg. 28, 389–400 (1965).Google Scholar
  56. Rick, W.: Der Secretin-Pankreozymin-Test in der Diagnostik der Pankreasinsuffizienz. Internist 11, 110–117(1970).PubMedGoogle Scholar
  57. Rosenberg, L.R., Friedland, N., Janowitz, H.D., Dreiling, D.A.: The effect of age and sex upon human pancreatic secretion of fluid and bicarbonate. Gastroenterology 50, 191–194 (1966).Google Scholar
  58. Sarles, H., Mercadier, M.: Les pancréatites chroniques de l’adulte. Paris: Expansion Scientifique Française 1960.Google Scholar
  59. Sarles, H., Pastor, J., Pauli, A.M., Barthelemy, M.: Determination of pancreatic function. Gastroenterologia 99, 279–300 (1963).Google Scholar
  60. Sarles, H., Salem, E., Cros, R.Ch., Figarella, C.: Exploration pancréatique par tubage. Acta gastro-ent. belg. 33, 303–318 (1970).Google Scholar
  61. Sarles, H., Worning, H.: Persönliche Mitteilung (1972).Google Scholar
  62. Schütz, H.B., Reizenstein, P.: Radiovitamin B12 as a dilution indicator in gastrointestinal research. Amer. J. dig. Dis. 8, 904–907 (1963).Google Scholar
  63. Sun, D.C.H.: The use of pancreozymin-secretin test in the diagnosis of pancreatitis and tumors of the pancreas. Gastroenterology 45, 203–208 (1963).PubMedGoogle Scholar
  64. Thaysen, E.H., Müllertz, S., Worning, H., Bang, H.O.: Amylase concentration of duodenal aspirates after stimulation of the pancreas by a standard meal, Gastroenterology 46, 23–31 (1964).PubMedGoogle Scholar
  65. Wootton, I.D.P., King, E.J.: Normal values for blood constituents. Lancet 1953/I, 470–471.Google Scholar
  66. Wormsley, K.G.: Response to secretin in man. Gastroenterology 54, 197–209 (1968 a).PubMedGoogle Scholar
  67. Wormsley, K.G.: The action of secretin on the secretion of enzymes by the human pancreas. Scand. J. Gastroent. 3, 183–188 (1968 b).PubMedGoogle Scholar
  68. Wormsley, K.G.: The response to infusion of a combination of secretin and pancreozymin in health and disease. Scand. J. Gastroent. 4, 623–632 (1969 a).PubMedGoogle Scholar
  69. Wormsley, K.G.: Response to duodenal acidification in man. I. Electrolyte changes in the duodenal aspirate. Scand. J. Gastroent. 4, 717–726 (1969b).PubMedGoogle Scholar
  70. Wormsley, K.G.: Stimulation of pancreatic secretion by intraduodenal infusion of bile-salts. Lancet 1970/II, 586–588.Google Scholar
  71. Wormsley, K.G.: Pancreatic function tests. In: Howat, H.T. (Ed.), The exocrine pancreas. Clinics in gastroenterology, Vol. 1, S. 27–51. London: Saunders 1972.Google Scholar
  72. Zieve, L., Silvis, S.E., Mulford, B., Blackwood, W.D.: Secretion of pancreatic enzymes. Amer. J. dig. Dis. 11, 671–684(1966).PubMedGoogle Scholar

Literatur

  1. Althausen, T.L., Uyeyama, K.: A new test of pancreatic function based on starch tolerance. Ann. int. Med. 41, 563–575 (1954).PubMedGoogle Scholar
  2. Bronstein, H.D., Haeffner, L.J., Kowlessar, O.D.: Gelatine-tolerance test. Gastroenterology 50, 621–624(1966).PubMedGoogle Scholar
  3. Cerda, J.J., Brooks, F.P., Prockop, J.D.: Intraduodenal hydrolyis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes. Gastroenterology 54, 358–365 (1968).PubMedGoogle Scholar
  4. Chey, W.Y., Shay, H., Nielson, O.E.: Evaluation of tests of pancreatic function in chronic pancreatic disease. JAMA 201, 247–253 (1967).Google Scholar
  5. Glaubitt, D.: 14CO2-Exhalationsmessungen zur Untersuchung der gastrointestinalen Resorption. Z. klin. Chem. 7, 107 (1969).Google Scholar
  6. Heinrich, H.: Diskussionsbemerkung. In: Aktuelle Gastroenterologie, Bartelheimer, H., Heisig, N. (Hrsg.). S. 247. Stuttgart: Thieme 1968.Google Scholar
  7. Pimparkar, B.D., Tulsky, E.G., Kalser, M.H., Bockus, H.L.: Correlation of radioactive and chemical fecal fat in different malabsorption syndromes. Brit. Med. J. 2, 894–896 (1964).Google Scholar
  8. Ritter, U., Uthgenannt, H.: Der 14C-Tripalmitat-Test als differentialdiagnostisches Verfahren bei Resorptionsinsuffizienzen. Dtsch. Z. Verdau.-Stoffwechselkr. 28, 2–4 (1968).Google Scholar
  9. Thiel, G.B., Benoit, F.L., Watten, R.H.: An oral gelatin-xylose test for estimating pancreatic proteolytic activity. Amer. J. dig. Dis. 8, 1008–1016 (1963).Google Scholar
  10. Tuna, N., Mangold, A.K., Mosser, D.G.: Re-evaluation of the 131J-triolein absorption test. J. Lab. clin. Med. 61, 620–624 (1966).Google Scholar

Literatur

  1. Ammon, H.V., Phillips, S.F.: Fatty acids inhibit intestinal water absorption in man: fatty acid diarrhea? (abstr.). Gastroenterology 62, 717 (1972).Google Scholar
  2. Benson, J.H., Culver, P.J., Ragland, S., Jones, C.M., Drumney, C.D., Bongas, E.: The d-xylose absorption test in malabsorption syndromes. New Engl. J. Med. 256, 235–339 (1957).Google Scholar
  3. Berkowitz, D., Sklaroff, D., Woldow, A., Gerson-Jakobs, A., Likoff, W.: Blood absorption pattern of isotopically labeled fat and fatty acid. Ann. Intern. Med. 56, 247–256 (1959).Google Scholar
  4. Bonnet, J.D., Hightower, N.C., Rodarte, J.R.: Correlation between blood and fecal radioactivity after oral administration of I131-labeled triolein. J. Amer. Med. Ass. 181, 35–37 (1962).Google Scholar
  5. Brien, F.S., Turner, D.A., Watson, E.M., Geddes, J.H.: A study of carbohydrate and fat absorption from the normal and diseased intestine in man. 1. The absorption and excretion of d-xylose. Gastroenterology 20, 287–293 (1952).PubMedGoogle Scholar
  6. Bright-Asare, P., Binder, H.J.: Hydroxy fatty acids (OHFA) stimulate colonic secretion of water and electrolytes (abstr.). Gastroenterology 62, 727 (1972).Google Scholar
  7. Broitman, S.A., Bondy, D.C., Yachnin, I., Hoskins, I.C., Ingbar, S., Zamchek, N.: Absorption and disposition of d-xylose in thyreotoxicosis and myxedema. New Engl. J. Med. 270, 333–337 (1964).PubMedGoogle Scholar
  8. Bronstein, H.D., Haeffner, L.J., Kowlessar, O.D.: The significance of gelatin tolerance in malabsorption states. Gastroenterology 50, 621–630 (1966).PubMedGoogle Scholar
  9. Butterworth, C.E., Jr., Perez-Santiago, E., Martinez de Jesus, J., Santini, R.: Studies on the oral and parenteral administration of d (+) xylose. New. Engl. J. Med. 216, 157–164 (1959).Google Scholar
  10. Castle, W.B.: Gastric intrinsic factor and vitamin B12 absorption. In: Handbook of Physiology Sect. 6 Alimentary Canal S. 1529–1553. Hrsg. Amer. Physiol. Soc. Washington: C.F. Code 1968.Google Scholar
  11. Christiansen, P.H., Kirsner, J.B., Ablaza, J.: D-Xylose and its use in the diagnosis of malabsorptive states. Amer. J. Med. 27, 443–453 (1959).PubMedGoogle Scholar
  12. Clark, P.A.: The use of the d-xylose excretion test in children. Gut 3, 333–335 (1962).PubMedGoogle Scholar
  13. Cocco, A.E., Rosenzweig, N.S., Hendrix, T.R.: Absorption of Xylose against a concentration gradient in vivo. Clin. Res. 13, 252 (1965) (abstr.).Google Scholar
  14. Comfort, M.W., Wollaeger, E.E., Taylor, A.B., Power, M.H.: Non-tropical sprue: observations on absorption and metabolism. Gastroenterology 23, 155–178(1953).PubMedGoogle Scholar
  15. Csaky, T.Z., Lassen, U.V.: Active intestinal transport of d-xylose. Biochim. biophys. Acta (Amst.) 82, 215–217 (1964).Google Scholar
  16. Culver, P.J.: Survey of methods for study of intestinal absorption. Amer. J. Dis. 2, 620–627 (1957).Google Scholar
  17. Dick, M.: Use of cupronsthiocyanate as a short-term continons marker for faeces. Gut 10, 408–412 (1969).PubMedGoogle Scholar
  18. Dietschy, J.M.: Mechanismus for the intestinal absorption of bile acids. J. Lipid. Res. 9, 297–309 (1968).PubMedGoogle Scholar
  19. Dietschy, J.M., Salomon, H.S., Siperstein, M.D.: Bile acid metabolism. I. Studies on the mechanisms of intestinal transport. J. Clin. Invest. 45, 832–836 (1966).PubMedGoogle Scholar
  20. Drumney, G.D., Benson, J.A., Jones, C.M.: Microscopical examination of the stool for steatorrhea. New. Engl. of. Med. 264, 85 (1961).Google Scholar
  21. Duthie, H.L., Webster, J.H.H., Hindmarsh, J.T.: Inhibition of d-xylose absorption by L-histidine (abstr.). Gut 7, 104(1966).Google Scholar
  22. Erb, W., Siede, W.: Pankreasdiagnostik mit dünnschichtgromatographischer Stuhlfettanalyse. Med. Klin. 68, 550–554 (1973).PubMedGoogle Scholar
  23. Ewe, K., Romahn, A., Oberhausen, E.A.: Vitamin B12-Resorption und ihre Beeinflussung durch Intrinsic factor bei Normalen und Ileumresezierten. In: Aktuelle Berichte aus dem Gebiet der Verdauung-und Stoffwechselkrankheiten. R. Ammon und U. Ritter, Hrsg. Stuttgart: G. Thieme Verlag 1971.Google Scholar
  24. Faust, R.G., Hollifield, J.W., Leadbetter, M.G.: D-xylose: active intestinal transport in a sodium ion substituted lithium medium. Nature 215, 1297–1298 (1967).PubMedGoogle Scholar
  25. Finlay, J.M., Hogarth, J., Wightman, K.J.R.: A clinical evalution of the D-xylose tolerance test. Ann. Intern. Med. 61, 411–422 (1964).PubMedGoogle Scholar
  26. Finlay, J.M., Wightman, K.J.R.: The xylose-tolerance test as a measure of the intestinal absorption of carbohydrate in sprue. Ann. Intern. Med. 49, 1332–1347 (1958).PubMedGoogle Scholar
  27. Fordtran, J.S., Soergel, K.H., Ingelfinger, F.J.: Intestinal absorption of d-xylose in man. New. Eng. J. Med. 267, 274–279 (1962).PubMedGoogle Scholar
  28. Fourman, L.P.R.: The absorption of xylose in steatorrhoea. Clin. Sci. 6, 289–294 (1948).PubMedGoogle Scholar
  29. Fowler, D., Cooke, W.T.: Diagnostic significante of d. Xylose excretion test. Gut 1, 67–70 (1969).Google Scholar
  30. Frazer, H.C., Stewart, H.C.: Ultramicroscopic particles in normal human blood. J. Physiol 90, 18–24(1937).PubMedGoogle Scholar
  31. Fromm, H., Hofmann, A.F.: Breath test for altered bile — acid metabolism. Lancet 1971II, 621–625.Google Scholar
  32. Gardner, F.H.: A malabsorption syndrome in military personel in Puerto Rico. Arch. Intern. Med. 98, 44–60 (1956).Google Scholar
  33. Gardner, F.H., Perez-Santiago, El: Oral absorption tolerance tests in tropical sprue. Arch. Intern. Med. 98, 4, 67–474 (1956).Google Scholar
  34. Gerson, C.D., Cohen, N., Janowitz, H.D.: Small intestinal absorptive function in regional enteritis. Gastroenterology 64, 907–912 (1973).PubMedGoogle Scholar
  35. Goldstein, F., Karacodag, S., Wirts, C.W., Kowlessar, O.D.: Intraluminal small-intestinal utilization of d-xylose by bacteria. Gastroenterology 59, 380–386(1970).PubMedGoogle Scholar
  36. Gräsbeck, R., Gordin, R., Kantero, L., Kuhlback, B.: Selective vitamin B12 malabsorption and proteinuria in young people. A syndrome. Acta med. Scand. 167, 289–296 (1960).PubMedGoogle Scholar
  37. Gräsbeck, R., Nyberg, W.: Inhibition of radiovitamin B12 absorption by ethylene-diaminetetraace-tate (EDTA) and its reversal by calcium ions. Scand. J. clin. Lab. Invest. 10, 448 (1958).PubMedGoogle Scholar
  38. Green, P.A., Wollaeger, E.E.: The clinical behavor of sprue in the Unites States Gastroenterology 38, 399–418 (1960).PubMedGoogle Scholar
  39. Guth, P.H.: Physiological alteration in small bowel function with age. Amer. J. dig. Dis. 13, 565–571 (1968).PubMedGoogle Scholar
  40. Haihara, S., Wagner, H.N.: Measurement of intestinal fat absorption with carbon—14 labeled tracers. J. Lab. clin. Med. 71, 400–411 (1968).Google Scholar
  41. Heinrich, H.C., Gabbe, E.E.: Die Gesamtkörperretentionsmessung als empfindlicher und präziser Test für die quantitative Bestimmung der intestinalen Resorption. I. Der Radio-Vitamin-B12-Resorptions-Gesamtkörperretentionstest. Atompraxis 10, 477–485 (1964).Google Scholar
  42. Hess, D.R., Gregory, D.M., Thompson, J.B., Welsh, J.D.: Para-aminosalicylic acid induced intestinal malabsorption. Clin. Res. 18, 77 (1970).Google Scholar
  43. Imerslund, O.: Idiopathic chronic megaloplastic anemia in children. Acta paediat. Scand. Suppl. 119, 49, 1–115(1960).Google Scholar
  44. Jacobson, E.D., Chodos, R.B., Faloon, W.W.: An experimental malabsorption syndrome induced by neomycin. Amer. J. Med. 28, 524–533 (1960).PubMedGoogle Scholar
  45. Joske, R.A., Curnow, D.H.: The d-xylose absorption test. Aust. Ann. Med. 11, 4–14 (1962).PubMedGoogle Scholar
  46. Joske, R.A., Haagensen, L.J.: The 5 g d-xylose absorption test. J. clin. Pathol. 17, 154–155 (1964).PubMedGoogle Scholar
  47. Jover, A., Gordon, R.S.: Procedure for quantitative analysis of feces with special reference to fecal fatty acids. J. Lab. clin. Med. 59, 878–884 (1962).PubMedGoogle Scholar
  48. Kahan, J.: The vitamin A absorption test I. Studies on children and adults without disorders in the alimentary tract. Scand. J. Gastroent. 4, 313–324 (1969).PubMedGoogle Scholar
  49. Kahan, J.: The vitamin A absorption test II. Studies on children and adults with disorders in the alimentary tract, Scand. J. Gastroent. 5, 5–12 (1970).PubMedGoogle Scholar
  50. Kamer, J.H. Van de, Bokkel Ten, Huinink, H., Weyers, H.A.: Rapid method for the determination of fat in feces. J. biol. Chem. 177, 347–355 (1949).Google Scholar
  51. Kaplan, E., Edidin, B., Fruin, R.C., Baker, L.A.: Intestinal absorption of iodine 131-labeled triolein and oleic acid in normal subjects and in steatorrhea. Gastroenterology 34, 901–909 (1958).PubMedGoogle Scholar
  52. Kendall, M.J.: The influence of age on the xylose absorption test. Gut 11, 498–501 (1970).PubMedGoogle Scholar
  53. Klipstein, F.A.: Tropical sprue. Gastroenterology 54, 275–293 (1968).Google Scholar
  54. Lack, L., Weiner, I.M.: In vitro absorption of bile salts by small intestine of rats and guinea pigs. Amer. J. Physiol. 200, 313–317 (1961).PubMedGoogle Scholar
  55. LeBauer, Bauer, E., Smith, K., Greenberger, N.J.: Pancreatic insufficiency and vitamin B12 malabsorption. Arch, intern. Med. 122, 423–425 (1968).Google Scholar
  56. Lee, M.F., Temperley, J.M., Dick, M.: Estimation of faecal fat excretion using cuprons thiocyanate as a continous marker. Gut 10, 754–759 (1969).PubMedGoogle Scholar
  57. Lindenbaum, J., Rybak, B., Gerson, C.D., Rubin, E., Lieber, C.S.: Effects of ethanol on the small intestine of man. Clin. Res. 18, 385 (1970).Google Scholar
  58. MacIntyre, P.A., Sachs, M.V., Krevans, J.R., Conley, C.L.: Pathogenesis and treatment of macrocytic anemia. Arch, intern. Med. 98, 541–549 (1956).Google Scholar
  59. Martin, G.A., Clark, M.L., Senior, J.R., Distribution of d-xylose in sequestered fluid resulting in false-positive test for malabsorption. Ann. Intern. Med. 69, 1155–1162 (1968).Google Scholar
  60. McCance, Madders, K.: The comparative rates of absorption of sugars from human intestine. Bioehem. J. 24, 795–804 (1930).Google Scholar
  61. Meeuwisse, G.W., Dano, G.: The xylose absorption test in infancy. Acta paediat. Scand. 54, 33–42 (1965).PubMedGoogle Scholar
  62. Nieweg, H.O., Abels, J., Veeger, W., Hellmans, N.: The defective absorption of vitamin B12 in pancreatic insufficiency. In: Vitamin B12 and Intrinsic factor. Second Europ. Symp. Hamburg. H.C. Heinrich, Hrsg. S. 610–612. Stuttgart: Enke Verlag 1962.Google Scholar
  63. Paaby, P., Norvin, E.: The absorption of vitamin B12 during treatment with para-aminosalicylic acid. Acta Med. Scand. 180, 561–564 (1966).PubMedGoogle Scholar
  64. Palva, L.P., Heinivaara, O., Mattela, M.: Drug-induced malabsorption of vitamin B12 III. Interference of PAS and folic acid in the absorption of vitamin B12. Scand. J. Haemat. 3, 149–153 (1966).PubMedGoogle Scholar
  65. Perman, G., Gullberg, R., Reizenstein, P.G., Snellman, B., Allgen, R.-G.: A study of absorption patterns in malabsorption syndromes. Acta med. Scand. 168, 117–125 (1960).PubMedGoogle Scholar
  66. Pimparkar, B.D., Tulsky, E.G., Kalser, M.H., Bockus, H.C.: Correlation of radioactive and chemical fecal fat determination in various malabsorption syndromes. II Results in ideopathic steatorrhea and diseases of the pancreas. Amer. J. Med. 30, 927–939 (1961).PubMedGoogle Scholar
  67. Pitkänen, E., Svinhufvud, U.: Excretion of D-threitol after administration of d-xylose in man. Ann. Med. exp. Fenn. 43, 250–253 (1965).PubMedGoogle Scholar
  68. Reizenstein, P.G., Cronkite, E.P., Cohn, S.H.: Measurement of absorption of vitamin B12 by whole-body gamma spectrometry. Blood 18, 95–101 (1961).PubMedGoogle Scholar
  69. Rinaldo, J.A., Gluckman, R.F.: Maximal absorption capacity for xylose in nontropical sprue. Gastroenterology 47, 248–250 (1964).PubMedGoogle Scholar
  70. Roe, J.H., Rice, E.W.: Photometric method for determination of free pentose in animal tissues. J. biol. Chem. 173, 507–512 (1948).PubMedGoogle Scholar
  71. Ruffin, J.M., Keever, I.C., Chears, W.C., Shingleton, W.W., Baylin, G.J., Isley, J.K., Sanders, A.P.: Further observation on the use of I131-labeled lipids in the study of diseases of the gastrointestinal tract. Gastroenterology 34, 484–490 (1958).PubMedGoogle Scholar
  72. Salokannel, S.J., Palva, L.P., Takkunen, J.T.: Malabsorption of vitamin B12 during treatment with slow-release potassium chloride. Acta med. Scand. 187, 431–432 (1970).PubMedGoogle Scholar
  73. Saunders, D.R.: Medium chain triglycerides and the Van de Kamer method. Gastroenterology 52, 135–136(1967).PubMedGoogle Scholar
  74. Santini, R., Jr., Sheehy, T.W., Martinez de Jesus, J.: The xylose tolerance test with a five-gram dose. Gastroenterology 40, 772–774 (1961).PubMedGoogle Scholar
  75. Shamma’a, M.H., Ghazanfar, S.A.S.: D-xylose test in enteric fever, cirrhosis and malabsorptive states. Brit. Med. J. 1960II, 836–838.Google Scholar
  76. Sherr, H.P., Newman, A., Sasaki, Y., Bauwell, J.G., Hendrix, T.R.: Detection of bacterial deconjugation of bile salts by a convenient breath analysis technique (abstr.). Gastroenterology 60, 801 (1971).Google Scholar
  77. Shimoda, S.S., Saunders, D.R., Rubin, C.E.: The Zollinger-Ellison syndrome with steatorrhea. II The mechanismus of fat and vitamin B12 malabsorption. Gastroenterology 55, 705–723 (1968).PubMedGoogle Scholar
  78. Shiner, M., Vakil, B.J., Wilcox, P.B.: Urinary xylose excretion in stetorrhea. Gut 3, 240–244 (1962).PubMedGoogle Scholar
  79. Sickinger, K., Hanneman, H.: Die titrimetrische Stuhlfettbestimmung nach Van de Kamer bei Gabe von mittelkettigen Triglyceriden. Klin. Wschr. 46, 1005–1007 (1968).PubMedGoogle Scholar
  80. Smith, A.N.: Clinical pathophysiology in: Regional Enteritis, Crohn’s Disease. Skandia Internat. Symp. A. Engel, T. Larsson, Hrsg. S. 41–55. Stockholm: Nordiska Bokhandels Färlag 1971.Google Scholar
  81. Soong, C.S., Thompson, J.B., Poley, J.R., Hess, D.R.: Hydroxy fatty acids in human diarrhea. Gastroenterology 63, 748–757 (1972).PubMedGoogle Scholar
  82. Schedl, H.P., Talley, R.B., Clifton, J.A.: Glucose and electrolyte absorption in the normal human small intestine: inhibition by xylose (abstr.). J. Clin. Invest. 43, 1232 (1964).Google Scholar
  83. Schilling, R.F.: Intrinsic factor studies II. The effect of gastric juice on the urinary excretion of radioactivity after oral administration of radioactive vitamin B12. J. Lab. Clin. Med. 42, 860–866(1953).PubMedGoogle Scholar
  84. Schjönsby, H.: The effect of bacteria on intestinal uptake of vitamin B12 I. Effect of blind-loop contents. Gut 13, 119–128 (1972).Google Scholar
  85. Schjönsby, H., Hofstad, T.: Effect of bacteria on intestinal uptake of vitamin B12 II. The consequences of in vitro preincubation of B12 with pure bacterial populations. Scand. J. Gastroent. 7, 253–359 (1972).Google Scholar
  86. Texter, E.C., Cooper, J.A.D., Vidinli, M., Finlay, J.M.: Laboratory procedures in the diagnosis of malabsorption. Med. Clin. N. Amer. 48, 117–136 (1964).PubMedGoogle Scholar
  87. Tuna, N., Mangold, H.K., Mosser, D.G.: Re-evaluation of the I131-Triolein absorption test. J. Lab. Clin. Med. 61, 620–628 (1963).PubMedGoogle Scholar
  88. Uthgenannt, H., Ritter, U., Hesse, L.: Die Prüfung der Pankreasfunktion mit dem Glyzerin-14C1-Tripalmitat-Test. Z. Gastroent. 5, 169 (1967).Google Scholar
  89. Vartio, T.: D-xylose tolerance test in achlorhydria. Ann. Med. Intern. Fenn. 49, 317–321 (1960).PubMedGoogle Scholar
  90. Wagner, A.: Zur quantitativen Bestimmung der in den Faeces ausgeschiedenen Proteine. Klin. Wschr. 45, 1056(1967).PubMedGoogle Scholar
  91. Walker, B.E., Kelleher, J., Davies, T., Losowsky, M.S.: Chemical feacal fat using single stools. Scand. J. Gastroent. 6, 277–280 (1971).PubMedGoogle Scholar
  92. Watson, W.C., Dickson, C.: Experience of a new procedure for faecal analysis. Gut 5, 488–489 (1964).PubMedGoogle Scholar
  93. Webb, G.I., Chodos, R.B., Mahar, C.G., Faloon, W.W.: Mechanismus of vitamin B12 malabsorption in patients receiving colchicine. New. Eng. J. Med. 279, 845–850 (1968).PubMedGoogle Scholar
  94. Wilson, F.A., Dietschy, J.M.: Differential diagnostic apporoach to clinical problems of malabsorption. Gastroenterology 61, 911–931 (1971).PubMedGoogle Scholar
  95. Wormsley, K.G.: Use of labeled triolein, vitamin A., and d-xylose in the diagnosis of malabsorption. Gut 4, 261–272(1963).PubMedGoogle Scholar
  96. Wyngaarden, J.B., Segal, S., Foley, J.B.: Physiological disposition and metabolic fate of infused pentoses in man. J. Clin. Invest. 36, 1395–1407 (1957).PubMedGoogle Scholar

Literatur

  1. Ammann, R.: Enzymdiagnostik der Pankreaserkrankungen. Schweiz, med. Wschr. 99, 504–513 (1969).Google Scholar
  2. Burke, J.O., Plummer, K., Bradford, S.: Serum amylase response to morphine, mecholyl and secretin as a test of pancreatic function. Gastroenterology 15, 699–707 (1950).PubMedGoogle Scholar
  3. Burton, P., Hammond, E.M., Harper, A.A., Howat, H.T., Oleesky, S., Varley, H.: Use of secretin and pancreozymin in man. Gastroenterologia (Basel) 86, 463–464 (1956).Google Scholar
  4. Burton, P., Hammond, E.M., Harper, A.A., Howat, H.T., Scott, J.E., Varley, H.: Serum amylase and serum lipase levels in man after administration of secretin and pancreozymin. Gut 1, 125–139 (1960).PubMedGoogle Scholar
  5. Braganza, J.M., Howat, H.T.: Cancer of the pancreas. In: Clinics in Gastroenterology. Howat, H.T. (ed.): The exocrine pancreas. Vol. 1, p. 219–237. London: W.B. Saunders 1972.Google Scholar
  6. Chey, W.Y., Shay, H., Nielsen, O.F., Lorber, S.H.: Evaluation of lests of pancreatic function in chronic pancreatic disease. J. Amer. med. Ass. 201, 347–350 (1967).Google Scholar
  7. Dreiling, D.A.: The early diagnosis of pancreatic cancer. Scand. J. Gastroent. Suppl. 6, 115–122 (1970).Google Scholar
  8. Dreiling, D.A., Richman, A.: Evaluation of provocative blood enzyme tests employed in diagnosis of pancreatic disease. Arch, intern. Med. 94, 197–211 (1954).Google Scholar
  9. Dreiling, D.A., Janowitz, H.D.: The measurement of pancreatic secretory function. In: The exocrine pancreas. S. 225. London: Ciba Foundation Symposia, Churchill Ltd. 1962.Google Scholar
  10. Fitzgerald, O., Fitzgerald, P., Fennelly, J., McMullin, L.P., Boland, S.J.: A clinical study of chronic pancreatitis. Gut 4, 193–216 (1963).PubMedGoogle Scholar
  11. Goebell, H.: Zum Sekretionsverhalten der normalen und geschädigten Bauchspeicheldrüse. Habilitationsschrift. Marburg 1969.Google Scholar
  12. Goebell, H., Bode, Ch., Lemberg, G.: Lipase und Amylase im Serum bei Stimulation des normalen und geschädigten Pankreas mit Sekretin-Pankreozymin. Deutsch, med. Wschr. 94, 2086–2097 (1969).Google Scholar
  13. Heffernon, E.W., Gunter, A.R.: Evaluation of the secretin test in pancreatic disease. Gastroenterology 19, 526–532 (1951).PubMedGoogle Scholar
  14. Howat, H.T.: Usefulness of gastrointestinal hormones in diagnosis. Gastroenterology 42, 72–76 (1962).PubMedGoogle Scholar
  15. Knight, W.A., Muether, R.O., Sommer, A.J.: Chronic recurrent pancreatitis. II. Serial serum diastase levels following prostigmine stimulation. Gastroenterology 12, 34–48 (1949).PubMedGoogle Scholar
  16. Lagerlöf, H., Perman, G.: The effect of secretin injection on the serum amylase in man. Acta chirurg, scand. 111, 22–28 (1956).Google Scholar
  17. Lopousniak, M.S., Bockus, H.L.: Study of pancreatic serum enzymes following secretin injection in pancreatic affections. Gastroenterology 16, 294–308 (1950).Google Scholar
  18. Malinowski, T.S.: Serum amylase response to pancreatic stimulation as a test of pancreatic disease. Amer. J. Med. Sci. 222, 440–445 (1951).PubMedGoogle Scholar
  19. Myhre, J., Nesbitt, S., Hurly, J.T.: Response of serum amylase and lipase to pancreatic stimulation as a test of pancreatic function. Gastroenterology 13, 127–134 (1949).PubMedGoogle Scholar
  20. Olbermann, M., Prellwitz, W., Recke, S.: Evokationstest mit Sekretin und Pankreozymin als diagnostisches Hilfsmittel beim Oberbauchsyndrom. Deutsch, med. Wschr. 98, 8–11 (1973).Google Scholar
  21. Popper, H.L., Necheles, H.: A new test for pancreatic function: Experimental observations. Gastroenterology 1, 490–499 (1943).Google Scholar
  22. Rick, W.: Zur Pathologie der Enzymsekretion des Pankreas. Acta Gastroent. Belg. 28, 389–400 (1965).PubMedGoogle Scholar
  23. Rick, W.: Chronische Pankreatitis. Symptomatologie, Laboratoriumsdiagnostik und konservative Therapie. Chirurg. 39, 301–306 (1968).PubMedGoogle Scholar
  24. Rick, W.: Kinetischer Test zur Bestimmung der Serumlipaseaktivität. Z. klin. Chem. u. klin. Biochem. 7, 530–539 (1969).