Abstract
In a study of the critical molecular events early during infection and cell transformation by tumor viruses, it is useful to analyze virus-cell systems in which most cells are rapidly infected and transformed. Although DNA tumor viruses are generally not suitable, for they transform only a small fraction of cells they infect (3), RNA tumor viruses (oncornaviruses), under suitable conditions, can efficiently infect and transform most cells in culture (4). In this process, viral RNA is reversibly transcribed to DNA, which is then integrated into the cellular genome. Integrated viral DNA is transcribed to viral mRNA molecules, some of which code for information responsible for transforming cells and maintaining the transformed state of the cell (4).
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Green, M., Salzberg, S., Robin, M.S., Loni, M.C., Bhaduri, S., Shanmugam, G. (1975). Synthesis of Viral DNA and Transcription of Viral RNA during Infection and Cell Transformation by the Murine Sarcoma-Leukemia Virus. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_22
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DOI: https://doi.org/10.1007/978-3-642-66112-9_22
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