Abstract
RNA tumor viruses replicate via a pathway involving both DNA synthesis and DNA-dependent RNA synthesis (6,7,14). The first step in the pathway probably involves the action of viral RNA-dependent DNA polymerase to yield covalent RNA:DNA hybrid structures. By a mechanism, presently unknown, this intermediate is converted to DNA, which is found integrated in the host chromosome. It may be that, once integrated, viral and host genes are treated identically, and subsequent steps depend upon the nuclear transcription machinery.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Axel, R., Cedar, H., and Felsenfeld, G. The synthesis of globin RNA from duck reticulocyte chromatin in vitro. Proc. Natl. Acad. Sci. USA, 70:2029, 1973.
Baluda, M. A. and Drohan, W. N. Distribution of DNA complementary to RNA of avian myeloblastosis virus in tissues of normal and tumor-bearing chickens. J. Virol., 10:1002, 1972.
Chambon, P., Gissinger, F., Mandel, J. L., Kedinger, C, Gniazdowski, A., and Meihlac, M. Purification and properties of calf thymus DNA dependent RNA polymerases A and B. Cold Spring Harbor Symp. Quant. Biol., 35:693, 1970.
Cox, R. F. Transcription of high molecular weight RNA from hen-oviduct chromatin by bacterial and endogenous form B, RNA polymerases. Eur. J. Biochem., 39:49, 1973.
Crick, F. General model for the chromosome of higher organisms. Nature, 234:25, 1971.
Gallo, R. C. Reverse transcriptase, the DNA polymerase of oncogenic RNA viruses. Nature, 234:194, 1971.
Green, M. Oncogenic viruses. Ann. Rev. Biochem., 39:701,1970.
Huang, R. C. and Huang, P. C. Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin. J. Mol. Biol., 39:365, 1969.
Ikawa, Y., Ross, J., and Leder, P. An association between globin messenger RNA and 60 S RNA derived from Friend leukemia virus. Proc. Natl. Acad. Sci. USA, 71:1154, 1974.
Jacquet, M., Groner, Y., Monroy, G., and Hurwitz, J. The in vitro synthesis of avian myeloblastosis viral RNA sequences. Proc. Natl. Acad. Sci. USA, 71:3045, 1974.
McDonnell, J. P., Garapin, A. C, Levinson, W. E., Quintrell, N., Fanshier, L., and Bishop, J. M. DNA polymerase of Rous sarcoma virus. Delineation of two reactions with actinomycin. Nature, 228:433, 1970.
Rosenthal, P. N., Robinson, H. L., Robinson, W. S., Hanafusa, T. DNA in uninfected and virus infected cells complementary to avian tumor virus RNA. Proc. Natl. Acad. Sci. USA, 68:2336,1971.
Rymo, L., Parsons, J. T., Coffin, J. M., and Weissman, C. In vitro synthesis of Rous sarcoma virus RNA is catalyzed by a DNA-dependent RNA polymerase. Proc. Natl. Acad. Sci. USA, 71:2782, 1974.
Temin, H. M. and Baltimore, D. RNA-Directed DNA synthesis and RNA tumor viruses. Adv. Virus Res., 17:129, 1972.
Weinberg, R. A. Nuclear RNA metabolism. Ann. Rev. Biochem., 42:329, 1973.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Jacquet, M., Groner, Y., Monroy, G., Hurwitz, J. (1975). In Vitro Transcription Studies with RNA Tumor Viruses. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-66112-9_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66114-3
Online ISBN: 978-3-642-66112-9
eBook Packages: Springer Book Archive