6-aminonicotinamide (6-AN), an antimetabolite of nicotinamide has been used in experimental medicine under two different aspects:
  1. a)

    as antimetabolite that after administration in experimental animals results in well-defined and reproducable disorders of the brain like spastic paralysis of the extremities (Johnson and McColl, 1955; Sternberg and Philips, 1957; Wolf, Cowen and Geller, 1959) as well as a continual decrease of the body temperature and prolongation of the sleeping period following a hexobarbital anaesthesia (Redetzki and Alvarez-O’Bourke, 1962; Coper and Herken, 1963; Coper, Hadass and Lison, 1966; Lison, 1970) and leads to the formation of brain edema (Schneider, 1970; Schochet, 1970; Meyer-König, 1973);

  2. b)

    as teratogenic agent.



Brain Edema Superior Colliculus Ganglion Cell Layer Ventricular Zone Ventricular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin-Heidelberg 1975

Authors and Affiliations

  • Andreas Raedler
    • 1
  • Jobst Sievers
    • 1
  1. 1.Anatomisches InstitutUniversität HamburgHamburg 20Federal Republic of Germany

Personalised recommendations