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The Effect of Mannitol, Steroids and Hypocapnia on the Intracranial Volume/Pressure Response an Experimental and Clinical Study

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Intracranial Pressure II

Abstract

The volume/pressure response (VPR) is defined as the change in ventricular fluid pressure (VFP) caused by a small induced change in the volume of fluid in the lateral ventricle. It has been shown, both in patients with raised ICP (1, 2) and in baboons undergoing experimental brain compression (3), that a direct relationship can be demonstrated between VFP and VPR. Therefore, during the reduction of intracranial hypertension, if the configuration of the volume/pressure curve remains unchanged, the fall in VFP should be paralleled by an equivalent fall in VPR.

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References

  1. MILLER, J.D., GARIBI, J.: Intracranial volume pressure relationships during continuous monitoring of ventricular fluid pressure. In: Brock, M., Dietz, H. (eds.): Intracranial Pressure, pp. 270–274. Berlin-Heidelberg-New York: Springer-Verlag 1972.

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  2. MILLER, J.D., GARIBI, J., PICKARD, J.D.: Induced changes in cerebrospinal fluid volume. Effects during continuous monitoring of ventricular fluid pressure. Arch. Neurol. 28, 265–269 (1973).

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  3. LEECH, P.J., MILLER, J.D.: Intracranial volume pressure relationships during experimental brain compression in primates. 1. Pressure responses to changes in ventricular volume. J. Neurol. Neurosurg. Psychiat. (1974). In press.

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  4. LUNDBERG, N.: Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiat. Neurol. Scand. 36, suppl. 149, 1–193 (1960).

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  5. LEECH, P.J., MILLER, J.D.: Intracranial volume pressure relationships during experimental brain compression in primates. 2. The effect of induced changes in systemic arterial pressure and cerebral blood flow. J. Neurol. Neurosurg. Psychiat. (1974). In press.

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© 1975 Springer-Verlag Berlin Heidelberg

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Leech, P.J., Miller, J.D. (1975). The Effect of Mannitol, Steroids and Hypocapnia on the Intracranial Volume/Pressure Response an Experimental and Clinical Study. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_77

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  • DOI: https://doi.org/10.1007/978-3-642-66086-3_77

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66088-7

  • Online ISBN: 978-3-642-66086-3

  • eBook Packages: Springer Book Archive

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