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Evidence for Bulk Flow of Cerebral Interstitial Fluid and its Possible Contribution to Cerebrospinal Fluid Production

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Abstract

We have recently developed a new technique designed to measure bulk flow of cerebral interstitial fluid (ISF) and, using this technique, have obtained evidence (1) supporting the classical view of cerebrospinal fluid formation by brain, i.e. of a slow “lymphatic” flow of ISF from brain to CSF via a perivascular canalicular system (2). This paper summarizes evidence suggesting bulk flow of ISF along the course of cerebral blood vessels and also presents new data showing transfer of radio-iodinated ( 131I) human serum albumin (RISA) from brain to CSF.

Keywords

  • Human Serum Albumin
  • Caudate Nucleus
  • Brain Edema
  • Bulk Flow
  • Cerebral Blood Vessel

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This investigation was supported by NIH Grant NS 11050. H.F.C. is the recipient of Research Career Development Award NS 70500.

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References

  1. CSERR, H.F., OSTRACH, L.H.: Bulk flow of interstitial fluid following intracranial injection of Blue Dextran 2000. Exp. Neurol, (in press).

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  2. WEED, L.H.: Studies on cerebro-spinal fluid. No. IV. The dual source of cerebro-spinal fluid. J. Med. Res. 26, 93–113 (1914).

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  3. BASS, N.H., LUNDBORG, P.: Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: clearance of carboxyl -[14C] inulin after intrathecal infusion. Brain Res. 52, 323–332 (1973).

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  4. CSERR, H.F.: Physiology of the choroid plexus. Physiol. Rev. 51, 273–311 (1971).

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  5. EDVINSSON, L., NIELSEN, K.C., OWMAN, CH., WEST, K.A.: Alterations in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta physiol. scand. 82, 527–531 (1971).

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© 1975 Springer-Verlag Berlin Heidelberg

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Cserr, H.F., Tang, D.T. (1975). Evidence for Bulk Flow of Cerebral Interstitial Fluid and its Possible Contribution to Cerebrospinal Fluid Production. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-66086-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66088-7

  • Online ISBN: 978-3-642-66086-3

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