Abstract
The pathophysiology of cerebral dysfunction in normal pressure hydrocephalus (NPH) and the mechanism of clinical improvement in NPH patients who undergo cerebrospinal fluid (CSF) shunting are still unclear. The hypothesis of GREITZ (1) that cerebral circulation is adversely affected by “brain distension” in conditions like NPH and the reports of improvement of cerebral blood flow (CBF) concomittant with clinical improvement after CSF shunting (2,3,4) led us to study cerebral hemodynamics and their relationship to changes in cerebrospinal fluid pressure (CSFP) in patients with NPH and “hydrocephalus ex vacuo” due to cerebral atrophy. The primary aim of the study was to determine the existence of any abnormal cerebral hemodynamics in NPH and if so, to examine their implications in the treatment and prognosis.
This work was supported by grant NS 09287 from the National Institute of Neurological Diseases and Stroke, and in part by grant RR 00350 from the General Clinical Research Centers Branch, Division of Research Resources, National Institutes of Health, Bethesda, Maryland 20014 (USA).
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© 1975 Springer-Verlag Berlin Heidelberg
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Mathew, N.T., Hartmann, A., Meyer, J.S., Ott, E.O. (1975). The Importance of “CSF Pressure-Regional Cerebral Blood Flow Dysautoregulation” in the Pathogenesis of Normal Pressure Hydrocephalus. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_30
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DOI: https://doi.org/10.1007/978-3-642-66086-3_30
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