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Volume Pressure Curves and Pial Vascular Pressure Gradients in the Rhesus Monkey

  • S. Nakatani
  • Ayub K. Ommaya

Abstract

The volume pressure relationships (VPR) within the cranial cavity is of fundamental importance in understanding the mechanisms of brain damage in a variety of conditions. The conventional teaching concerning the VPR under conditions of increasing intracranial pressure (ICP) is that the relationship is smoothly exponential after a brief period of volume increase without significant pressure rise (1). Two years ago we presented data which showed that departures from such an idealized exponential curve are the rule if the factor of rate of mass expansion is considered. We also discovered a critical rate for continuous expansion of an extradural supratentorial mass below which a vasopressor response was not very prominent thereby markedly affecting the shape of the VPR (2). Thus, brain death (as recognized by fixed dilated pupils and an isoelectric EEG) was produced at relatively low levels of ICP.

Keywords

Brain Death Balloon Inflation Mass Expansion Volume Pressure Curve Volume Pressure Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    LANGFITT, T.W.: Increased intracranial pressure. In Clinical Neurosurgery. Proceedings of the Congress of Neurological Surgeons, pp. 436–471. Baltimore, Maryland: Williams and Wilkins 1969.Google Scholar
  2. 2.
    NAKATANI, S., OMMAYA, A.K.: A critical rate of cerebral compression. In: Brock, M., Dietz, H. (eds.): Intracranial Pressure, pp. 144–148. Berlin-Heidelberg-New York: Springer-Verlag 1972.CrossRefGoogle Scholar
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    LÖFGREN, J.: Pressure-volume relationships of the cerebrospinal fluid system. Thesis, Gothenburg (1973).Google Scholar
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    OMMAYA, A.K., METZ, H., POST, K.D.: Observations on the biomechanics of hydrocephalus. In: Harbert, J. (ed.): Cisternography and Hydrocephalus, pp. 57–74. Baltimore: Williams and Wilkins 1972.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • S. Nakatani
  • Ayub K. Ommaya

There are no affiliations available

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