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Mechanical Basis of the CSF Pressure-Volume Curve

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Abstract

The pressure which is built up in the CSF compartment because of the continuous input of fluid is dependent upon the resistance to the outflow of the fluid in the outflow channels and the pressure in the recipient system. Thus, the volume of separate intracranial components including space-occupying masses does not directly affect the fluid pressure under steady conditions. When there is a change, however, in the volume of some component there is an immediate change in the pressure in the same direction. The magnitude of the initial response of the fluid pressure to the volume change is determined by the elastance of the CSF system defined as the slope dP/dV of its pressure-volume curve. A brief description of the pressure-volume curve in the human was presented by RYDER et al. 1953 (1). The present outline of the mechanical properties of the CSF system is based on a series of experiments in dogs recording the pressure-volume curve in different circumstances (2,3,4,5). The pressure-volume curve was obtained by rapid continuous intrathecal injection of fluid with simultaneous measurement of the pressure. The injection rate was selected in order to minimize errors due to the concomitant loss of fluid in the outflow channels and the generation of dynamic pressure gradients.

Keywords

  • Fluid Pressure
  • Arterial Inflow
  • Outflow Channel
  • Cerebrospinal Fluid Space
  • Recipient System

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-3-642-66086-3_16
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References

  1. RYDER, H.W., ESPEY, P.P., KIMBELL, F.D., PENKA, E.J., ROSENAUER, A., PODOLSKY, B., HERGET, P., EVANS, J.P.: The elasticity of the craniospinal venous bed. J. Lab. Clin. Med. 42, 944 (1953)

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  2. LÖFGREN, J., VON ESSEN, C., ZWETNOW, N.N.: The pressure-volume curve of the cerebrospinal fluid space in dogs. Acta neurol. scand. 49, 557–574 (1973).

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  3. LÖFGREN, J., ZWETNOW, N.N.: Cranial and spinal components of the cerebrospinal fluid pressure-volume curve. Acta neurol. scand. 49, 575–585 (1973).

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  4. LÖFGREN, J.: Effects of variations in arterial pressure and arterial carbon dioxide tension on the cerebrospinal fluid pressure-volume relationships. Acta neurol. scand. 49, 586–598 (1973).

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  5. LöFGREN, J., ZWETNOW, N.N.: Influence of a supratentorial expanding mass on intracranial pressure-volume relationships. Acta neurol. scand. 49, 599–612 (1973).

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© 1975 Springer-Verlag Berlin Heidelberg

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Löfgren, J. (1975). Mechanical Basis of the CSF Pressure-Volume Curve. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_16

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  • DOI: https://doi.org/10.1007/978-3-642-66086-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66088-7

  • Online ISBN: 978-3-642-66086-3

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