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A Computer Model of CSF Dynamics

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CSF production per time unit (F) is linearly proportional to the pressure gradient between choroidal vessels and CSF space (1, 2). Thus, the following formula holds true:

$$ F = {{K}_{1}} \cdot \left( {{{P}_{A}} - {{P}_{{CSF}}} - {{\pi }_{{PL}}}} \right) $$

, where PA = pressure in the choroidal vessels, π PL = oncotic pressure of the blood, PCSF = CSF pressure, and K1 = a factor representing metabolic influences. The CSF pressure/absorption relationship was examined experimentally. The resulting curve for CSF pressure/ absorption relationship was transformed into a polynomial by regression analysis:

$$ A = {{a}_{o}} + {{a}_{l}}\left( {{{P}_{{CSF}}} - {{P}_{S}}} \right) + \ldots + {{a}_{n}}{{\left( {{{P}_{{CSF}}} - {{P}_{S}}} \right)}^{n}} $$

, where A = absorption of CSF per time unit, PS = sinus pressure. The CSF volume (∆V) is given by

$$ V = \int\limits_{o}^{t} {\left( {F - A} \right)} \cdot dt $$


Key words

  • CSP dynamics
  • computer model
  • CSF pressure
  • CSF production
  • CSF drainage

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  • DOI: 10.1007/978-3-642-66086-3_13
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© 1975 Springer-Verlag Berlin Heidelberg

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Hofferberth, B., Matakas, F., Fritschka, E. (1975). A Computer Model of CSF Dynamics. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg.

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66088-7

  • Online ISBN: 978-3-642-66086-3

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