Effects of Hypercapnia on Pupillary Size, ICP and Cerebral Venous PO2 during Experimental Brain Compression

  • J. Douglas Miller
Conference paper


When active cerebral vasodilatation occurs during progressive supratentorial brain compression it causes increasingly large rises in ICP. It has been suggested that such episodes of intracranial hypertension produced by vasodilatation may produce neurological deterioration either through cerebral ischaemia consequent on a fall in cerebral perfusion pressure (1) or by promoting tentorial herniation of the brain (2).This investigation was directed towards this problem.

Key word

Hypercapnia intracranial pressure brain shift 


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  1. 1.
    JENNETT, W.B., BARKER, J., FITCH, W., MCDOWALL, D.G.: The effect of anaesthesia on intracranial pressure in patients with space-occupying lesions. Lancet i, 61–64 (1969).Google Scholar
  2. 2.
    FITCH, W., MCDOWALL, D.G.: Effect of halothane on intracranial pressure gradients in the presence of intracranial space-occupying lesions. Brit. J. Anaesth. 43, 904–912 (1971).PubMedCrossRefGoogle Scholar
  3. 3.
    KETY, S.S., SCHMIDT, C.F.: The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J. Clin. Invest. 27, 484–492 (1948).CrossRefGoogle Scholar
  4. 4.
    REID, W.L., CONE, W.V.: The mechanism of fixed dilatation of the pupil resulting from ipsilateral cerebral compression. J. Amer. Med. Ass. 112, 2030–2034 (1939).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • J. Douglas Miller

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