Zusammenfassung
Es würde zu weit führen, die sehr umstrittenen Fragen nach der Spezifität biologischer oder immunologischer Insulin-Bestimmungsverfahren sowie laboratoriums- und anwendungsbezogene Vorteile und Nachteile einzelner Methoden selbst hier im einzelnen zu diskutieren. Immunchemisch wird im Serum sicher nur Insulin und, abhängig von der Spezifität der verwendeten Antiseren, zugleich auch Proinsulin gemessen. Die üblicherweise durch Immunisierung von Meerschweinchen gewonnenen Antiinsulinseren erfassen außer Proinsulin sehr wahrscheinlich auch — soweit diese im Serum oder Plasma vorkommen — weitere Insulinvorstufen, wie Desdipeptid-Proinsulin und die Arginin-Insuline. Außer immunchemisch reagierendem Insulin (IRI) bzw. Insulin-ähnlichem immunoreaktivem Material kann in Serum oder Plasma biologisch Insulin-ähnliche Aktivität (ILA) nachgewiesen werden.
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Frerichs, H. (1975). Die Sekretion des Insulins. Stimulierung und Hemmung. In: Cerasi, E., et al. Diabetes mellitus · A. Handbuch der inneren Medizin, vol 7 / 2 / A. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66033-7_4
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