Zusammenfassung
Die histologischen Grundeigenschaften des Inselgewebes der Bauchspeicheldrüse wurden vor allem aufgrund der Arbeiten von Langerhans (1893), Lane (1907) and Bensley (1911) genauer bekannt. Auf Basis dieser älteren Arbeiten und zahlreicher neuer eigener Unterlagen veröffentlichte Bargmann (1939) eine ausgezeichnete Zusammenfassung unserer Kenntnisse auf dem Gebiet der Normalhistologie des endokrinen Pankreas.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Ahronheim, J.H.: The nature of the hyaline material in the pancreatic islands in diabetes mellitus. Amer. J. Path. 19, 873–882(1943).
Arey, B.: Nature of hyaline material in the pancreatic islands in diabetes mellitus. Arch. Path. 36, 32–38(1943).
Assche, A. van: The fetal endocrine pancreas. Proefschrift. Katholieke Universiteit Leuven 1970.
Barboni, E., Manocchio, I.: Alterazioni pancreatiche in Bovini con diabete mellito post aftoso. Arch. vet. ital. 13, 477–489(1962).
Bargman, W.: Die Langerhansschen Inseln des Pankreas. In Handbuch der Mikroskopischen Anatomie des Menschen, Bd. VI/2. Innersekretorische Drüsen, I. Berlin: Springer 1939.
Barnett, H.R.J., Marshall, R.B., Seligman, A.M.: Histochemical demonstration of insulin in the islets of Langerhans. Endocrinology 57, 419–438(1955).
Bastenie, P.: Cortico-surrénale et diabète humain. Paris: Masson & Cie. 1956.
Baum, J., Simons, B.E., Unger, R.H., Madison, L.S.: Localization of glucagon in the alpha cells in the pancreatic islet by immunofTuorescent technic. Diabetes 11, 371–374(1962).
Bell, E.T.: Carcinoma of the pancreas: A clinical and pathologic study of 609 necropsied cases: The relation of carcinoma of the pancreas to diabetes mellitus. Amer. J. Path. 33, 499–523. (1957).
Bencosme, S.A., Liepa, E., Lazarus, S.S.: Glucagon content of pancreatic tissue devoid of alpha cells. Proc. Soc. exp. Biol. (N.Y.) 90, 387–392(1955).
Bensley, R.R.: Studies on the pancreas of the guinea-pig. Amer. J. Anat. 12, 297–388(1911/12).
Berson, S.A., Yalow, R.S.: Some current controversies in diabetes research. Diabetes 14, 549–572(1965).
Björkman, N., Hellerström, C., Hellman, B., Petersson, B.: The cell types in the endocrine pancreas of the human fetus. Z. Zellforsch. 72, 425–445(1966).
Bloom, W.: A new type of granular cell in the islets of Langerhans of man. Anat. Rec. 49, 363–371(1931).
Büchner, F.: Inselzellen Adenom des Pankreas mit Hypoglykämie bei Diabetes. Klin. Wschr. 11, 1494–1496(1932).
Campenhout, E. van, Cornelis, G.: Destruction expérimentale des cellules alpha des ilots endocrines du pancréas chez le cobaye. C.R. Soc. Biol. (Paris) 145, 933–935(1951).
Capella, C., Solcia, E., Vassallo, G.: Identification of six types of endocrine cells in the gastrointestinal mucosa of the rabbit. Arch. histol. jap. 30, 479–495(1969).
Cavallero, C., Solcia, E.: Cytological and cytochemical aspects of islet pathology in the Zollinger-Ellison syndrome. Rev. int. Hepat. 15, 517–526(1965).
Cerasi, E., Luft, R.: Plasma insulin response to glucose in healthy subjects and in diabetes mellitus. Acta. endocr. (Kbh.) 55, 278–304(1967).
Cerasi, E., Luft, R.: Further studies on healthy subjects with high and low insulin response to glucose infusion. Acta endocr. (Kbh.) 55, 305–329(1967).
Cerasi, E., Luft, R.: Insulin response to glucose infusion. Acta endocr. (Kbh.) 55, 330–345(1967).
Cerasi, E., Luft, R.: “What is inherited hypothesis for the pathogenesis-what is added” of diabetes mellitus. Diabetes 16, 615–627(1967).
Christensen, N.O., Schambye, P.: On diabetes mellitus hos kvaeg. Nord. Vet.-Med. 2, 863–900(1950).
Church, R.E., Crane, W.A.J.: A cutaneous syndrome associated with islet cell carcinoma of the pancreas. Brit. J. Derm. 74, 284–286(1967).
Cole, L.: Diabetes mellitus in children. Lancet 1934 I, 947.
Conroy, M.J.: Quantitative and qualitative changes in the islands of Langerhans in diabetes mellitus. J. metab. Res. 2, 367–384(1922).
Craighead, J.E.: Virus induction of diabetes mellitus in mice. Amer. J. Path. 52, 56 (Abstr.) (1968)
Creutzfeldt, W.: Zur Deutung des Silberzellbildes und anderer Pankreasbefunde beim Diabetes mellitus und Inseladenome. Beitr. path. Anat. 113, 133–168(1953).
Creutzfeldt, W., Theodossiou, A.: Die Relation der A-und B-Zellen in den Pankreasinseln bei Nichtdiabetikern und Diabetikern. Beitr. Path. Anat. 117, 235–252(1957).
Crome, L., Erdohazi, M., Rivers, R.P.A.: Fulminating diabetes with lymphocytic thyroiditis. Arch. Dis. Childh. 42, 677–681(1967).
Deconinck, J., Potvliege, P.R., Gepts, W.: The ultrastructure of the human pancreatic islets. I. The islets of adults. Diabetologia 7, 266–282, 1971.
Dixit, P.K., Lowe, I., Lazarow, A.: Effect of alloxan on the insulin content of microdissected mammalian pancreatic islets. Nature (Lond.) 195, 388–389(1962).
Dourov, N., Buyl-Strouvens, M.L.: Agenesie du pancreas. Observation anatomoclinique d’un cas de diabéte sucrè, avec stéatorrhée et hypotrophie chez un nouveau-né. Arch. franc. Pediat. 26, 641–650(1969).
Ehrlich, J.C., Ratner, J.M.: Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and non-diabetic individuals. Amer. J. Path. 38, 49–59(1961).
Epple, A.: Zur vergleichenden Zytologie des Inselorgans. Verh. dtsch. Zool. Ges. 1963. Erganz. z. Zool. Anz. 27, 461–470(1964).
Faller, A.: Elektronmikroskopische Differenzierung verschiedener Inselzelltypen im Pankreas normaler Albino-Ratten. Z. Zellforsch. 97, 226–248(1969).
Ferner, H.: Über die Entwicklung der Langerhansschen Inseln nach der Geburt und die Bedeutung der versilberbaren Zellen im Pankreas des Menschen. Z. mikr.-Anat. Forsch. 44, 451–488(1938).
Ferner, H.: Beiträge zur Histobiologie der Langerhansschen Inseln des Menschen mit besonderer Beräcksichtigung der Silberzellen und ihrer Beziehung zum Pankreasdiabetes. Virchows Arch. path. Anat. 309, 87–136(1942).
Ferner, H.: Das Inselsystem des Pankreas. Stuttgart: Georg Thieme 1952.
Forssmann, W.G., Orci, L., Pictet, R., Renold, A.E., Rouiller, C.: The endocrine cells in the epithelium of the gastrointestinal mucosa of the rat. An electron microscope study. J. Cell Biol. 40, 692–715(1968).
Forssmann, W.G., Orci, L., Rouiller, C.: The problem of gastrin producing-cells. J. Cell Biol. 39, 167a (1968).
Freytag, G.: Histologische und autoradiographische Untersuchungen am Inselsystem der Maus beim Insulinantikorper-Diabetes. Beitr. path. Anat. 131, 121–148(1968).
Freytag, G., Klöppel, G.: Experimented Insulitis und Pankreatitis nach Immunseren gegen Pankreasextrakte verschiedener Reinheitsgrade. Beitr. path. Anat. 139, 138–160(1969).
Fujita, T.: D-cell, the third endocrine element of the pancreatic islet. Arch. histol. jap. 29, 1–40 (1968).
Gamble, D.R., Kinsley, M.L., Fitzgerald, M.G., Bolten, R., Taylor, K.W.: Viral antibodies in diabetes mellitus. Brit. med. J. 1969 III, 627–630.
Gellerstedt, N.: Die elektive insuläre (Para-)Amyloidose der Bauchspeicheldruse. Beitr. path. Anat. 101, 1–12(1938).
Gepts, W.: Contribution á l’étude morphologique des ilots de Langerhans au cours du diabete. Bruxelles: Acta Medica Belgica 1957.
Gepts, W.: Die histopathologischen Veränderungen der Langerhansschen Inseln und ihre Bedeutung in der Frage der Pathogenese des menschlichen Diabetes. Endokrinologie 36, 185–211(1958).
Gepts, W.: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14, 619–633 (1965).
Gepts, W., Gregoire, F.: Quantitative histochemistry of the endocrine pancreas. In: Recent advances in quantitative histo-and cytochemistry: methods and applications (eds. Dubach, U.C., Schmidt, U.). Bern-Stuttgart-Vienna: Hans Huber 1971.
Gepts, W., Gregoire, F., Assche, A. van, Gasparo, M. de: Quantitative enzyme pattern and insulin content of human islets. In. The structure and metabolism of the pancreatic islets, (eds.: Falkmer, S., Hellman, B., Täljedal, B.). Oxford: Pergamon Press 1970.
Gepts, W., Toussaint, D.: Spontaneous diabetes in dogs and cats. A pathological study. Diabetologia 3, 249–265(1967).
Glenner, G.G., Lillie, R.D.: The histochemical demonstration of indole derivatives by the postcoupled dimethylaminobenzylidine reaction. J. Histochem. Cytochem. 5, 279–296(1957).
Gossner, W.: Zur Enzymhistochemie der Langerhansschen Inseln. Verh. dtsch. Ges. Path. 42, 125–130(1959).
Gossner, W.: Die Enzymhistochemie der Langerhansschen Inseln: In: Fortschritte der Diabetesforschung (Oberdisse, K., Jahnke, K., Hrsg.). Stuttgart: Georg Thieme 1963.
Gössner, W., Korting, G.W.: Metastasierendes Inselzellcarcinom vom A-Zelltyp bei einem Fall von Pemphigus foliaceus mit Diabetes renalis. Dtsch. med. Wschr. 85, 434–437(1960).
Gömori, G.: Studies on the cells of the pancreatic islets. Anat. Rec, Suppl. 74, 439–459(1939).
Gömori, G.: Observations with differential stains on human islets of Langerhans. Amer. J.Path. 17, 395–406(1941).
Gömori, G.: Pathology of the pancreatic islets. Arch. Path. 36, 217–232(1943).
Gömori, G.: A new stain for elastic tissue. Amer. J. clin. Path. 20, 665–666(1950).
Gregory, R.A., Tracy, H.J.: The constitution and proporties of two gastrins extracted from hog antral mucosa. Gut 5, 103–114(1964).
Greider, M.H., Bencosme, S.A., Lechago, J.: The human pancreatic islet cells and their tumors: 1. The normal pancreatic islets. Lab. Invest. 22, 344–354(1970).
Greider, M.H., Elliott, D.W.: Electron microscopy of human pancreatic tumors of islet origin. Amer. J.Path. 44, 663–678(1964).
Grimelius, L.: A silver nitrate stain for α2-cells in human pancreatic islets. Acta Soc. Med. Upsalien. 73, 243–270(1968).
Gundersen, E.: Is diabetes of infectious origin? J.infect. Dis. 41, 197–202(1927).
Gusek, W., Kracht, J.: Elektronenmikroskopische Untersuchungen über Inselwachstum und acinoinsuläre Transformation. Frankfurt: Z. Path. 70, 98–106(1959).
Haarstad, J.: Hormone producing insulumo in diabetes mellitus. Acta med. scand. 159, 247–249(1957).
Hammar, A.J.: Ein Fall von Aplasie der Gallenblase und des Pankreas ventrale, sowie von Überentwicklung der primaren Gallengangsplatte bei einem 7,2 mm langen Menschenembryo. Z. mikr. anat. Forsch. 5, 90–94(1925).
Hartroft, W.S.: Islet pathology in diabetes. Diabetes 5, 98–104(1956).
Heiberg, K.: Studien über die pathologischen anatomischen Grundlage des Diabetes mellitus. Virchows Arch. path. Anat. 204, 175–189(1911).
Hellerström, C.: Effects of steroid diabetes on the pancreatic islets of guinea pigs with special reference to the A1 cells. Acta Soc. Med. Upsalien. 68, 1–16(1963).
Hellerström, C., Hellman, B.: Some aspects of silver impregnation of the islets of Langerhans in the rat. Acta endocr. (Kbh.) 35, 418–532(1960).
Hellerström, C., Hellman, B., Petersson, B., Alm, G.: The two types of pancreatic A-cells and their relation to the glucagon secretion. In: The structure and metabolism of the pancreatic islets (eds. Brolin, S.E., Hellman, B., Knutson, H.). Oxford: Pergamon Press 1964.
Hellerström, C., Westman, I.: Oxygen consumption of the B-cells in relation to the insulin release. In: The structure and metabolism of the pancreatic islets (eds. Falkmer, I., Hellman, B., Täljedal, B.). Oxford: Pergamon Press 1970.
Hellman, B.: Actual distribution of the number and volume of the islets of Langerhans on different size classes in non-diabetic humans of varying ages. Nature (Lond.) 184, 1498 (1959).
Hellman, B.: Islet morphology and glucose metabolism in relation to the specific function of the pancreatic B-cells. In: Diabetes. Proceedings of the sixth Congress of the International Diabetes Federation (eds. Östman, J.). Amsterdam: Excerpta Medica Foundation 1969.
Hellman, B.: Methodological approaches to studies on the pancreatic islets. The Minkowsky Award lecture. Diabetologia 6, 110–120(1970).
Hellman, B., Hellerström, C.: Histology and histophysiology of the islets of Langerhans in man. In: Diabetes mellitus (ed. Pfeiffer E.F.),Band I. München: J.F.Lehmann 1966.
Hellman, B., Lernmark, A.: Evidence for an inhibitor of insulin release in the pancreatic islets. Diabetologia 5, 22–24(1969).
Hellman, B., Petersson, B.: Long-term changes of the A2-cells in the islets of Langerhans of rats with alloxan diabetes. Endocrinology 72, 238–242(1963).
Hellman, B., Wallgren, A., Hellerström, C.: The identification of a specifica type of A-cell located in the central part of the pancreatic islets of the horse. Gen. comp. Endocr. 2, 558–564(1962).
Hensler, L., Hartmann, H.: Diabetes mellitus, kompensiert durch Beta-Zelladenom des Pankreas. Schweiz. med. Wschr. 86, 630–631(1956).
Herman, L., Sato, T., Fitzgerald, P.J.: The pancreas. In: Electron microscopic anatomy (ed. Kurtz, S.M.). New York and London: Academic Press 1964.
Hinden, E.: Mumps followed by diabetes. Lancet 19621, 1381.
House, E.L.: A histological study of the pancreas, liver and kidney both during and after recovery from alloxan diabetes. Endocrinology 62, 189–200(1958).
Hughes, H.: Cyclical changes in the islets of Langerhans in the rat pancreas. J. Anat. (Lond.) 81, 82–92(1947).
Hultquist, G.T., Dahlen, M., Helander, C.G.: Über die Technik der Darstellung und Zahlung der sog. Silberzellen in den Langerhansschen Inseln. Schweiz. Z. Path. Bakt. 11, 570–588(1948).
Hultquist, G.T., Tegner, B.: Beitrag zur Methodik bei Farbung von Granula in den Zellen der Langerhansschen Inseln. Schweiz. Z. Path. Bakt. 12, 717–722(1949).
Johnson, D.D.: Alloxan administration in the guinea pig. A study of the regenerative phase in the islands of Langerhans. Endocrinology 47, 393–398(1950).
Kawanishi, H., Akazawa, Y., Machii, B.: Islets of Langerhans in normal and diabetic humans. Ultrastructure and histochemistry, with special reference to hyalinosis. Acta path. jap. 16, 177–197(1966).
Kern, H.F., Kern, D.: Das A-Zellensystem des Menschen und der Wirbeltiere. In: Nebenschilddnise und endokrine Regulationen des Calcium-Stoffwechsels. Spontan-Hypoglykämie Glucagon (Kracht, H.J., Hrsg.). Berlin-Heidelberg-New York: Springer 1968.
Kipnis, D.M.: Insulin antagonism and diabetes mellitus. In: Diabetes Proceedings of the sixth Congress of International Diabetes Federation (eds.: Östman, J.). Amsterdam Excerpta Medica Foundation 1969.
Kobayashi, S., Fujita, T., Sasagawa, T.: The endocrine cells of human duodenal mucosa. An electron microscope study. Arch. histol. jap. 31, 477–494(1970).
Kracht, J.: Immunhistologische Untersuchungen mit Insulin am Inselorgan. In: Nebenschilddrüse und endokrine Regulationen des Calciumstoffwechsels. Spontan-Hypoglykämie Glucagon. Berlin-Heidelberg-New York: Springer 1968.
Kraus, E.J.: Die pathologisch-anatomischen Veränderungen des Pankreas beim Diabetes Mellitus. In: Handbuch der speziellen pathologischen Anatomie (Hrsg. Henke, F., Lubarsch, O.), Bd. 5/2. Berlin: Springer 1929.
Kremer, H.U.: Juvenile diabetes as a sequel to mumps. Amer. J. Med. 3, 257–258(1947).
Lacy, P.E.: The pancreatic B-cell. In: The aetiology of diabetes mellitus and its complications (eds. Cameron, M.P., O’Conner, M.). London: Churchill 1964.
Lacy, P.E., Davies, J.: Demonstration of insulin in mammalian pancreas by the fluorescent antibody method. Stain Technol. 34, 85–89(1959).
Lacy, P.E., Williamson, J.R.: Quantitative histochemistry of the islets of Langerhans. II. Insulin content of dissected B-cells. Diabetes 11, 101–104(1962).
Landing, B.H., Pettit, M.D., Wiens, R.L., Knowles, H., Guest, G.M.: Antithyroid antibody and chronic thyroiditis in diabetes. J. clin. Endocr. 23, 119–120(1963).
Lane, M.A.: The cytological characteristics of the areas of Langerhans. Amer. J. Anat. 7, 409–421(1907).
Langerhans, P.: Beiträge zur mikroskopischen Anatomie der Bauchspeicheldruse. Dissertation. Berlin 1869.
Lazarus, S.S., Volk, B.W.: Histochemical and electron microscopic studies of a functional insulinoma. Lab. Invest. 11, 1279–1294(1962).
Lazarus, S.S., Volk, B.W.: The pancreas in human and experimental diabetes. New York-London: Grune & Stratton 1962.
LeCompte, P.M.: “Insulitis” in early juvenile diabetes. Arch. Path. 66, 450–457(1958).
LeCompte, P.M., Legg, M.A.: Insulitis (lymphocytic infiltration of pancreatic islets) in late-onset diabetes. Diabetes 21, 762–769(1972).
LeCompte, P.M., Merriam, J.C.: Mitotic figures and enlarged nuclei in the islands of Langerhans in man. Diabetes 11, 35–39(1962).
LeCompte, P.M., Steinke, J., Soeldner, J.S., Renold, A.E.: Changes in the islets of Langerhans in cows injected with heterologous and homologous insulin. Diabetes 15, 586–596(1966).
Leduc, E.H., Jones, E.E.: Acinar-islet transformation in mouse pancreas. J. Ultrastruct. Res. 24, 165–169(1968).
Like, A.A.: The ultrastructure of the secretory cells of the islets of Langerhans in man. Lab. Invest. 16, 937–951(1967).
Logothetopoulos, J.: Diskussion — Bemerkung zu Orci, L., Rufener, C., Pictet, R., Renold, A.E., Rouiller, CH..: Present state of the evidence for mixed endocrine and exocrine pancreatic cells in spiny mice. In: The structure and metabolism of the pancreatic islets, (eds. Falkmer, S., Hellman, B., Täljedal, LB.) Pergamon Press: New York 1970.
Logothetopoulos, J., Bell, E.G.: Histological and autoradiographic studies of the islets of mice injected with insulin antibody. Diabetes 15, 205–211(1966).
Logothetopoulos, J., Kaneko, M., Wrenshall, G.A., Best, C.H.: Zinc granulation and extractable insulin of islet cells following hyperglycemia or prolonged treatment with insulin. In: The structure and metabolism of the pancreatic islets, (eds. Brolin, I., Hellman, B., Knusson, H.). Oxford: Pergamon Press 1964.
Lomsky, R., Langer, F., Vortel, V.: Immunohistochemical demonstration of gastrin in mammalian islets of Langerhans. Nature (Lond.) 223, 618–619(1969).
Lowry, O.H.: The quantitative histochemistry of the brain. Histological sampling. J. Histochem. Cytochem. 1, 420–428(1953).
Lowry, O.H., Passoneau, J.V., Rock, M.K.: The measurement of pyridine nucleotides by enzymatic cycling. J. biol. Chem. 236, 2746–2755(1961).
Ludwig, G., Heitner, H.: Zur Häufigkeit der Insel-Amyloi’dose des Pankreas beim Diabetes mellitus. Z. ges. inn. Med. 22, 814–819(1967).
Lukens, F.D.W.: The possible dangers of hyperglycemia. Proc. Amer. diab. Ass. 10, 103–115 (1950).
Lukens, F.D.W., Dyer, W.W.: Relation between the appearance and behaviour of the islands of Langerhans in man. Amer. J. med. Sci. 231, 313–319(1956).
Maclean, N., Ogilvie, R.F.: Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes 4, 367–376(1955).
Maclean, N., Ogilvie, R.F.: Observations on the pancreatic islet tissue of young diabetic subjects. Diabetes 8, 83–91(1959).
Mancini, R.M., Costanzi, G., Zampa, G.A.: Human insulin antibodies detected by immunofluorescence. Lancet 1964 I, 726.
Manocchio, S.: The metachromatic A-cells in the pancreatic islets of dogs of different age. In: The structure and metabolism of the pancreatic islets (eds. Brolin, S.E., Hellman, B., Knutson, H.). Oxford: Pergamon Press 1964.
Marble, A.: Cancer and diabetes. In: The treatment of diabetes mellitus (eds. Joslin, E.P., Root, H.F., White, P., Marble, A.). Philadelphia: Lea & Febiger 1959.
Masi, A.T., Hartmann, W.H., Hahn, B.H., Abbey, H., Shulman, L.E.: Hashimoto’s disease. A clinicopathological study with matched controls: lack of significant associations with other “auto immune” disorders. Lancet 1965 I, 123–126.
Matchinsky, F.M.: Quantitative histochemistry in the islets of Langerhans: In: Recent advances in qualitative histo-and cytochemistry. Methods and applications (eds. Dubach V.C., Schmidt U.). Bern-Stuttgart-Vienna: Hans Huber 1971.
Matchinsky, F.M., Ellerman, J.E.: Metabolism of glucose in islets of Langerhans. J. biol. Chem. 243, 2730–2736(1968).
McGavran, M.H., Hartroft, W.S.: The predilection of pancreatic beta cells for pigment deposition in hemochromatosis and hemosiderosis. Amer. J.Path. 32, 631 (abstr.) (1956).
McGavran, M.H., Unger, R.H., Recant, L., Polk, H.C., Kelo, C., Levin, M.E.: A glucagon secretory alpha-carcinoma of the pancreas. New Engl. J. Med. 274, 1408–1413(1966).
Melin, K., Ursing, B.: Diabetes mellitus somm komplikation till parotitis epidemica. Nord. med. 60, 1715–1717(1958).
Meyenburg, H. von: Über „Insulitis“ bei Diabetes. Schweiz. med. Wschr. 21, 554–537(1940).
Moore, R.A.: Congenital aplasia of islands of Langerhans with diabetes mellitus. Amer. J. Dis. Child. 52, 627–632(1936).
Moschowitz, E.: The pathogenesis of the hyalinisation of the islands of Langerhans. Arch. Path. 61, 136–142(1956).
Nakamura, N.: Untersuchungen über das Pankreas bei Foeten, Neugeborenen, Kindern und im Pubertatsalter. Virchows Arch. path. Anat. 253, 286–349(1924).
Nilsson, L.R., Doniach, D.: Autoimmune thyroiditis in children and adolescents. I. I. Clinical studies. Acta paediat. (Uppsala) 53, 255–268(1964).
Opie, E.L.: The relation of diabetes mellitus to lesions of the pancreas. J. exp. Med. 5, 527–540 (1900/01).
Orci, L., Pictet, R., Forssmann, W.G., Renold, A.E., Rouiller, CH.: Structural evidence of glucagon producing cells in the intestinal mucosa of the rat. Diabetologia 4, 56–67(1968).
Orci, L., Rufener, C., Pictet, R., Renold, A.E., Rouiller, CH.: Present state of the evidence for mixed endocrine and exocrine pancreatic cells in spiny mice: In: structure and metabolism of the pancreatic islets (eds. Falkmer, S., Hellman, B., Täljedal, I.B.). Pergamon Press: New York 1970.
Paget, G.E.: Aldehyde-thionin: a stain having similar proporties to aldehyde-fuchsin. Stain Technol. 34, 223–226(1959).
Pav, J., Jeskova, Z., Skhra, F.: Insulin antibodies. Lancet 1963 II, 221–222.
Pearse, A.G.E.: The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J. Histochem. Cytochem. 17, 303–313(1969).
Perley, M., Kipnis, D.M.: Plasma insulin response to glucose and tolbutamide of normal weight and obese diabetic and non-diabetic subjects. Diabetes 15, 867–874(1966).
Petersson, B., Hellerström, C., Hellman, B.: Some characteristics of the two types of A-cells in the islets of Langerhans of guinea-pigs. Z. Zellforsch. 57, 559–566(1962).
Pfeiffer, E.F.: Dynamik der Insulinsekretion. In: Fortschritte der Diabetesforschung (Hrsg. Oberdisse, K., Jahnke, K.). Stuttgart: G. Thieme 1963.
Pfeiffer, E.F., Ditschuneit, H., Ziegler, R.: Über die Bestimmung von Insulin im Blut am epididymalen Fettanhang der Ratte mit Hilfe markierter Glukose. Klin. Wschr. 39, 415–426(1961).
Porta, E.A., Yerry, R., Scott, R.F.: Amyloidosis of functionary islet cell adenomas of the pancreas. Amer. J. Path. 41, 623–627(1962).
Potvliege, P.R., Carpent, G., Gepts, W.: Über das Vorkommen von Mitosen in den Inselzellen des menschlichen Pankreas. Beitr. path. Anat. 128, 335–346(1963).
Renold, A.E.: Immunological studies with homologous and heterologous pancreatic insulin in the cow. In: Ciba Foundation Colloquia on Endocrinology. The aetiology of diabetes mellitus and its complications. Churchill: London 1964.
Rinehart, J.F., Toreson, W.E., Abul-Haj, S.K.: Histochemical studies of the hyaline in diabetes (Abstr.). Amer. J. Med. 17, 124(1954).
Rutter, W.J., Kemp, J.D., Bradshaw, W.S., Clark, W.R., Ronzio, R.A., Sanders, T.G.: Regulation of specific protein synthesis in cytodifferenciation. J. cell. comp. Physiol. 72, Suppl. 1, 1–18 (1968).
Schätzle, W.: Histochemie des Inselapparates. Acta histochem. (Jena) 6, 93–132(1958).
Schiebler, T.H., Schiessler, S.: Über den Nachweis von Insulin mit metachromatisch reagierenden Pseudoisocyaninen. Z. Zellforsch. 1, 445–465(1959).
Seifert, G.: Die pathologische Morphologie der Langerhansschen Inseln besonders beim Diabetes mellitus des Menschen. Verh. dtsch. Ges. Path. 18, 50–84(1959).
Seltzer, H.I., Allen, E.W., Herren, A.L., jr., Brennan, M.T.: Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J. clin. Invest. 46, 323–335(1967).
Seltzer, H.I., Harris, V.L.: Exhaustion of insulinogenic reserve in maturity onset diabetic patients during prolonged and continuous hyperglycemic stress. Diabetes 13, 6–13(1964).
Sheldon, J.H.: Hemochromatosis. London: Oxford University Press 1935.
Shibasaki, S., Ito, T.: Electron microscopic study of the human pancreatic islets. Arch. histol. jap. 31, 119–154(1969).
Shorr, S.S., Bloom, F.E.: Acino-insular cells in normal rat pancreas. Yale J. Biol. Med. 43, 47–49 (1970).
Solcia, E., Sampietro, R.: Cytologic observations on the pancreatic islets with reference to some endocrine-like cells of the gastro-intestinal mucosa. Z. Zellforsch. 68, 689–698(1965).
Solcia, E., Vassallo, G., Capella, C.: Studies on the G-cells of the pyloric mucosa, the probable origin of gastrin secretion. Gut 10, 379–388(1969).
Solcia, E., Vassallo, G., Sampietro, R.: Endocrine cells in the antro-pyloric mucosa of the stomach. Z. Zellforsch. 81, 474–486(1967).
Stampel, B.: Das Zink in den Langerhansschen Inseln verschiedener Tierarten. Verh. dtsch. Ges. Path. 42, 137–139(1959).
Steiner, H.: Insulitis beim perakuten Diabetes des Kindes. Klin. Wschr. 46, 417–421(1968).
Stöckenius, W.: Diskussion — Bemerkung zu W. Creutzfeldt. Verh. dtsch. Ges. Path. 42, 111 (1958).
Sutherland, E.W., Duve, Ch. de: Origin and distribution of the hyperglycemicglycogenolytic factor of the pancreas. J. biol. Chem. 175, 663–674(1948).
Thiery, J.P., Bader, J.: Ultrastructure des ilots de Langerhans du pancreas humain normal et pathologique. Ann. Endocr. (Paris) 27, 625–646(1966).
Toreson, W.E.: Glycogen infiltration (so-called hydropic degeneration) in the pancreas in human and experimental diabetes mellitus. Amer. J. Path. 27, 327–347(1951).
Toreson, W.E., Lee, J.C., Grodsky, G.M.: The histopathology of immune diabetes in the rabbit. Amer. J. Path. 52, 1099–1115(1968).
Unger, R.H.: The organ of Langerhans in new perspective. Amer. J. med. Sci. 260, 79–81(1970).
Vassalo, G., Solcia, E., Capella, C.: Light and electron microscopic identification of several types of endocrine cells in the gastrointestinal mucosa of the cat. Z. Zellforsch. 98, 333–356(1969).
Volk, B.W., Goldner, M.G., Frank-Crowley, H.: The effect of prolonged growth hormone administration on the pancreatic alpha cells in normal and hypophysectomized rats (use of a modification of Davenport’s silver impregnation method). Metabolism 4, 491–502 (1955).
Volk, B.W., Lazarus, S.S.: Ultramicroscopic evolution of B-cell destruction in diabetic dogs: In: The structure and metabolism of the pancreatic islets (eds. Brolin, S.E., Hellman, B., Knutson, H.). Oxford: Pergamon Press 1964.
Vries, A. de, Rachmilewitz, M., Schumert, M.: Pheochromocytoma with diabetes and hypertension. Amer. J. Med. 6, 51–59(1949).
Warren, SH., LeCompte, Ph. M., Legg, M.A.: The pathology of diabetes mellitus. Philadelphia Lea & Febiger 1966.
Weichert, R.F.: The neural ectodermal origin of the peptide secreting endocrine glands. Amer. J. Med. 49, 232–241(1970).
Weichselbaum, A.: Über die Veränderungen des Pankreas bei Diabetes mellitus. S.-B. kaiserl. Akad. Wiss. math.-nat. Kl. 119, 73–281(1910).
Yalow, R.S., Berson, S.A.: Plasma insulin concentrations in non-diabetic and early diabetic subjects. Diabetes 9, 254–260(1960).
Yalow, R.S., Berson, S.A.: Immuno-assay of plasma insulin in man. Diabetes 10, 339–344(1961).
Yoshinaga, T., Okuno, G., Skinji, Y., Tsujii, T., Nishikawa, N.: Pancreatic A-cell tumor associated with severe diabetes mellitus. Diabetes 15, 709–713(1966).
Zagury, D., Brux, J. de, Ancla, J., Leger, L.: Étude des ilots de Langerhans du pancréas humain au microscope électronique. Presse méd. 69, 887–890(1961).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Gepts, W. (1975). Die normale und pathologische Morphologie des Inselsystems. In: Cerasi, E., et al. Diabetes mellitus · A. Handbuch der inneren Medizin, vol 7 / 2 / A. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66033-7_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-66033-7_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66034-4
Online ISBN: 978-3-642-66033-7
eBook Packages: Springer Book Archive