Skip to main content
  • 135 Accesses

Abstract

By its participation in the structural buildup of the skeleton, calcium forms the metallic frame of the body. More than a kilogram of calcium is found in the human body; 99% of it is in bone, and the remainder is in the body fluids and soft tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Scott, B.L.: The occurrence of specific cytoplasmic granules in the osteoclast. J. Ultrastruct. Res. 19, 417–431 (1967)

    Article  PubMed  CAS  Google Scholar 

  2. Vincent, J.: Recherches sur la constitution de l’os adulte. Bruxelles: Editions Arscia 1955

    Google Scholar 

  3. Neuman, W.F., Neuman, M.W.: The chemical dynamics of bone mineral. Chicago: University of Chicago Press 1958

    Google Scholar 

  4. Young, R.A.: Dependence of apatite properties on crystal structural details. Trans. N.Y. Acad. Sci. 29 (series 2), 949–959 (1967)

    PubMed  CAS  Google Scholar 

  5. Bourne, G. (ed.): The biochemistry and physiology of bone. New York: Academic Press 1956

    Google Scholar 

  6. Glimcher, M., Andrikides, A., Kossiva, D.: Studies of the mechanism of calcification. I. The alteration of amino acid side chain groups of collagen and its effect on in vitro calcification. In: Structure and function of connective and skeletal tissue. Proc. Symp. NATO Advanced Study Institute, p. 342. London: Butterworth and Co., Ltd. (1964)

    Google Scholar 

  7. Glimcher, M.: The macromolecular aggregation state of collgen and biological specificity. In: Calcification, connective tissue, thrombosis and atherosclerosis (Page, I., ed.), p. 97–141. New York: Academic Press 1959

    Google Scholar 

  8. Bell, N.H.: Dynamics of bone metabolism. Annu. Rev. Med. 18, 299–312 (1967)

    Article  PubMed  CAS  Google Scholar 

  9. Saville, P.D.: Water fluoridation: effect on bone fragility and skeletal calcium content in the rat. J. Nutr. 91, 353–357 (1967)

    PubMed  CAS  Google Scholar 

  10. Wasserman, R.H., Corradino, R.A.: Metabolic role of vitamins A and D. Ann. Rev. Biochem. 40, 501–532 (1971)

    Article  PubMed  CAS  Google Scholar 

  11. Olson, E.B., DeLuca, H.F.: 25-Hydroxycholecalciferol: direct effect on calcium transport. Science 165, 405–407 (1969)

    Article  PubMed  CAS  Google Scholar 

  12. Horsting, M., DeLuca, H.F.: In vitro production of 25-hydroxycholecalci-ferol. Biochem. biophys. Res. Commun. 36, 251–256 (1969)

    Article  PubMed  CAS  Google Scholar 

  13. Tanaka, Y., DeLuca, H.F., Omdahl, J., Holick, M.: Mechanism of action of 1,25-dihydroxycholecalciferol on intestinal calcium transport. Proc. nat. Acad. Sci. (Wash.) 68, 1286–1288 (1971)

    Article  CAS  Google Scholar 

  14. Brickman, A.S., Coburn, J.W., Norman, A.W.: Action of 1,25-dihydroxy-cholecalciferol, a potent kidney-produced metabolite of vitamin D in uremic man. New Engl. J. Med. 287, 891–895 (1972)

    Article  PubMed  CAS  Google Scholar 

  15. Mawer, E.B., Taylor, C.M., Backhouse, J., Lumb, G., Stanbury, S.: Failure of formation of 1,25-dihydroxycholecalciferol in chronic renal insufficiency. Lancet 1, 626–628 (1973)

    Article  PubMed  CAS  Google Scholar 

  16. Trummel, C.L., Raisz, L.G., Blunt, J.W., DeLuca, H.F.: 25-Hydroxycholecalciferol: stimulation of bone resorption in tissue culture. Science 163, 1450–1451 (1969)

    Article  PubMed  CAS  Google Scholar 

  17. Schachter, D., Kowarski, S., Finkelstein, J.D.: Vitamin D3: direct action on the small intestine of the rat. Science 143, 143–144 (1964)

    Article  PubMed  CAS  Google Scholar 

  18. Dent, C.: Rickets and osteomalacia. In: Bone metabolism in relation to clinical medicine (Sissons, H., ed.). Proc. Symp., p. 78–87. London: Pitman Medical Publishing 1963

    Google Scholar 

  19. Arnstein, A.R., Frame, B., Frost, H.M.: Recent progress in osteomalacia and rickets. Ann. intern. Med. 67, 1296–1330 (1967)

    PubMed  CAS  Google Scholar 

  20. Greep, R.O., Talmage, R., eds.: The parathyroids. Proc. Symp. on Advances in Parathyroid Research. Springfield, Illinois: Charles C. thomas Publisher 1961

    Google Scholar 

  21. Park, E.A.: The imprinting of nutritional disturbances on the growing bone. Pediatrics 33 (Suppl.) 815–862 (1964)

    PubMed  Google Scholar 

  22. Aurbach, G.D., Potts, J.T., Jr.: The parathyroids. Advanc. Metab. Disord. 1, 45–93 (1964)

    CAS  Google Scholar 

  23. Aurbach, G.D., Potts, J.T., Jr.: Parathyroid hormones, editorial. Amer. J. Med. 42, 1–8 (1967)

    Article  PubMed  CAS  Google Scholar 

  24. Stoerk, H.C., Carnes, W.H.: Relation of dietary calcium-phosphorus ratio to serum calcium and to parathyroid volume. J. Nutr. 29, 43–50 (1945)

    CAS  Google Scholar 

  25. Aurbach, G.D., Chase, L.R.: Cyclic 3′, 5′-adenylic acid in bone and the mechanism of action of parathyroid hormone. Fed. Proc. 29, 1179–1182(1970)

    PubMed  Google Scholar 

  26. Urist, M.R.: Osteoporosis. Ann. Rev. Med. 13, 273–286 (1962)

    CAS  Google Scholar 

  27. Editorial: Nutrition and metabolic bone disease in the elderly. Nutr. Rev. 25, 71–72(1967)

    Google Scholar 

  28. Nordin, B.: Osteoporosis. Advanc. Metab. Disord. 1, 125–151 (1964)

    CAS  Google Scholar 

  29. Potts, J.T., Jr.: Recent advances in thyrocalcitonin research. Fed. Proc. 29, 1200–1205 (1970)

    PubMed  CAS  Google Scholar 

  30. Munson, P.L., Gray, T.K.: Function of thyrocalcitonin in normal physiology. Fed. Proc. 29, 1206–1208 (1970)

    PubMed  CAS  Google Scholar 

  31. Munson, P.L., Hirsch, P.F., Brewer, H.B., Reisfeld, R.A., Cooper, C.W., Wasthed, A.B., Orimo, H., Potts, J.T., Jr.: Thyrocalcitonin. Recent Progr. Hormone Res. 24, 589–650 (1968)

    CAS  Google Scholar 

  32. Marx, S.J., Woodard, C.J., Aurbach, G.D.: Calcitonin receptors of kidney and bone. Science 178, 999–1001 (1972)

    Article  PubMed  CAS  Google Scholar 

  33. Gatter, R.A., McCarty, D.J.: Pathological tissue calcifications in man. Arch. Path. 84, 346–353 (1967)

    Google Scholar 

  34. Giacomelli, F., Spiro, D., Wiener, J.: A study of metastatic renal calcification at the cellular level. J. Cell Biol. 22, 189–206 (1964)

    Article  PubMed  CAS  Google Scholar 

  35. Borle, A.B.: Calcium and phosphate metabolism. In: Annual review of physiology (Comroe, J.H., Jr., Sonnenschein, R.R., and Zierler, K.L., eds.), vol. 36, p. 361–390. Palo Alto, Calif: Annual Reviews Inc. 1974

    Google Scholar 

  36. Holick, M.F., DeLuca, H.F.: Vitamin D metabolism. In: Annual review of medicine (Creger, W.P., Coggins, C.H., and Hancock, E.W., eds.), vol. 25, p. 349–367. Palo Alto, Calif.: Annual Reviews Inc. 1974

    Google Scholar 

  37. Haymovits, A., Rosen, J.F.: Calcitonin in metabolic disorders. In: Advances in metabolic disorders (Levine, R., and Luft, R., eds.), vol. 6, p. 177–212. New York: Academic Press 1972

    Google Scholar 

  38. Rasmussen, H., Bordier, P. (eds.): The physiological and cellular basis of metabolic bone disease. Baltimore: The Williams & Wilkins Company 1974

    Google Scholar 

  39. Anderson, H.C.: Calcium-accumulating vesicles in the intercellular matrix of bone. In: Hard tissue growth, repair and remineralization. Ciba Symp. 11, p. 213–226. Amsterdam: Associated Scientific Publishers 1973

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Van Lancker, J.L. (1976). Calcium and Phosphorus Metabolism. In: Molecular and Cellular Mechanisms in Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65967-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-65967-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65969-0

  • Online ISBN: 978-3-642-65967-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics