Elimination of Cholesterol as Bile Acids in Hyperlipoproteinemias Type II and IV
Several studies indicate that cholesterol metabolism is regulated differently in hyperlipoproteinaemia type II and type IV (cf. Miettinen, 1973). Data on the turn-over of the two bile acids synthesized in the liver (cholic acid and chenodeoxycholic acid) show that the formation of bile acids in patients with a type II lipoprotein pattern is lower than in those with type IV (Kottke, 1969; Einarsson and Hellström, 1972; Wollenweber and Stiehl, 1972). This difference is mainly due to a subnormal synthesis of cholic acid in type II and an abnormally high formation of this bile acid in most subjects with type IV (Einarsson and Hellström, 1972). Further evidence that these two types of hyperlipoproteinaemia represent different entities of diseases affecting bile acid metabolism was obtained by studying the effect of hypolipemic drugs.
KeywordsBile Acid Pool Size Cholic Acid Chenodeoxycholic Acid Total Bile Acid
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