Necrogenic Agent Obtained from Cholesterol Used in Dietary Experiments

  • K. T. Lee
  • H. Imai
  • N. T. Werthessen
  • C. B. Taylor

Abstract

Necrosis of arterial smooth muscle cells is one of the important anatomic manifestations of atherosclerosis. We have in the past conducted a short-term experiment of five days in the swine and rhesus monkey and ascertained the necrogenic effect of crystalline cholesterol on the arterial smooth muscle cell. The objective of the current study was to determine if these short-term necrogenic effects could be due to cholesterol per se or to contaminants of the cholesterol, such as spontaneous oxidation products.

Keywords

Cholesterol Sucrose Foam Steam Citrate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1974

Authors and Affiliations

  • K. T. Lee
  • H. Imai
  • N. T. Werthessen
  • C. B. Taylor

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