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Enhancement of Cholesterol Metabolism by Colestipol Hydrochloride in Experimental Animals

  • Thomas M. Parkinson
  • Thomas Honohan
  • John C. SchneiderJr.
  • Gary Elfring
  • William A. Phillips
Conference paper

Abstract

Colestipol hydrochloride (Colestid®, The Upjohn Company), a polyethylenepolyamine polymer with l-chloro-2,3-epoxypropane, is a new bile acid sequestrant which lowers serum cholesterol levels in experimental animals (Parkinson et al., 1969; Marmo et al., 1970) and in man (Parkinson et al., 1969; Ryan and Jain, 1972; Glueck et al., 1972; Nye et al., 1972). Although type II, III and IV hyperlipo-proteinemic subjects respond to the drug, it appears to be most effective in those with elevated serum cholesterol and normal or only slightly elevated triglycerides (type II). Triglyceride levels generally are not significantly affected by colestipol. HCl therapy.

Keywords

Bile Acid Bile Acid Synthesis Bile Acid Sequestrant Bile Acid Excretion Elevated Serum Cholesterol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1974

Authors and Affiliations

  • Thomas M. Parkinson
  • Thomas Honohan
  • John C. SchneiderJr.
  • Gary Elfring
  • William A. Phillips

There are no affiliations available

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