Zusammenfassung
Die Chemotherapie maligner Tumoren ist wegen der unspezifischen Natur der heutigen Zytostatika nur in einem relativ schmalen Dosisbereich aussichtsreich. Einerseits sollten wegen der Dosisabhängigkeit der Tumorhemmwirkung möglichst hohe Dosen verwendet werden, andererseits sind dem durch die sogenannten Nebenwirkungen Grenzen gesetzt. Die wichtigste dosislimitierende Nebenwirkung betrifft das blutbildende Gewebe, im besonderen die Leukopoese.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
ALEKSANDROWICZ, J., BLICHARSKI, J.: Leucémie chez deux soeurs jumelles (Monozygotes), essai de traitment par la transfusion de la moelle osseuse. Extrait du Sang 31, 49 (1960).
ALTSCHULER, H., NADEL, E.M.: Comparison of storage at -20°C and at -190°C with lactic dehydrogenase (LDH) measurements on fresh serum. Cryobiology 3, 385/85 (1967).
AMATO, D., BERGSAGEL, D.E., CLARYSSE, A.M., COWAN, D.H., ISCOVE, N.N., MCCULLOCH, E.A., MILLER, R.G., PHILLIPS, R.A., RAGAB, A.H., SENN, J.S.: Review of bone marrow transplants at the Ontario cancer institute. Transplantation Proceedings 3 397 (1971).
AMIEL, J.L., SCHWARZENBERG, L., MATHE, G.: Bone marrow grafts and histocompatibility. Transplantation Proceedings 3, 1072 (1971).
ARIEL, I.M., PACK, G.T.: Treatment of disseminated melanoma by systemic Melphalan, Methotrexate and autogenous bone marrow transplants. Cancer (Philad.) 20, 77 (1967).
ARIENT, M., SKALA, E., POTMESIL, M., PALA, F., DUFEK, V.: On the treatment of acute leukemia by massive whole body irradiation combined with subsequent bone marrow transfusion. A case report. Neoplasma (Bratisl.) 7, 295 (1960).
BACH, F.H., ALBERTINI, R.J., ANDERSON, J.L., JOO, P., BORTIN, M.M.: Bone-marrow transplantation in a patient with the Wiskott-Aldrich-syndrome. Lancet 1968 II, 1364.
BEARD, A.G., BARNHARD, H.J., ROSS, S.W., CONLIN, F.D.: Acute leukemia treated by irradiation and marrow transplant. J. Pediat. 55, 42 (1959).
BEKKUM, D.W. VAN: Mitigation of acute secondary disease by treatment of the recipient with antilymphocytic serum before grafting of allogeneic hemopoietic cells. Exp. Hemat. 20, 3 (1970).
BEKKUM, D.W. VAN: Bone marrow transplantation. Transplantation Proceedings 3, 53 (1971).
BEKKUM, D.W. VAN, DICKE, K.A., BALNER, H., HOLLANDER, C.F., PUTTEN, L.M. VAN: Failure to obtain take of allogeneic bone marrow grafts in monkeys following pretreatment with Cyclophosphamide. Exp. Hemat. 20, 27 (1970).
BOECKL, O., HEITZ, N., KARRER, K., MANNHEIMER, E.: Methodik der autologen Knochenmarkstransplantation bei forcierter zytostatischer Therapie. Wien. klin. Wschr. 75, 349 (1963).
BOECKL, O., HEITZ, N., KARRER, K., MANNHEIMER, E.: Über die Möglichkeiten der Therapie bösartiger Tumoren mit hochdosierten Cytosta-tica. Arzneimittel-Forsch. 14, 797 (1964).
BORTIN, M.M.: A compendium of reported human bone marrow transplants. Transplantation 9, 571 (1970).
BORTIN, M.M., SALTZSTEIN, E.C., WAISBREN, B.A., KAY, S.A., HONG, R., BACH, F.H.: Bone marrow transplantation for aplastic anemia. Establishment of chimerism using multiple HL-A-identical donors following pretreatment with Caclophosphamide. Transplantation 12, 573 (1971).
BUCKNER, CD., EPSTEIN, R.B., RUDOLPH, R.H., CLIFT, R.A., STORB, R., THOMAS, E.D.: Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia. Blood 35, 741 (1970).
BUCKNER, CD., RUDOLPH, R.H., FEFER, A., CLIFT, R.A., EPSTEIN, R.B., FUNK, D.D., NEIMAN, P.E., SLICHTER, S.J., STORB, R., THOMAS, E.D.: High-dose Cyclophosphamide therapy for malignant disease. Toxicity, tumor response, and the effects of stored autologous marrow. Cancer (Philad.) 29, 357 (1972).
CHATAING, B., REVILLARD, J.P.: Bone marrow grafts. Cah. Med. Lyon. 44, 3061 (1968).
COLARUSSO, A.: Die Übertragung von Knochenmark bei einigen Blutkrankheiten. Rif. med. 15.8.1959.
CONGDON, C.C.: Summary of discussions. AET-bone marrow conference. Oak Ridge/Tennessee January 9 and 10, 1959.
CONGDON, C.C.: Cooperative group on bone marrow transplantation in man. Human and large-animal marrow grafts attempted in 1968 – 69 with Cyclophosphamide. Exp. Hemat. 20, 97 (1970).
CONGDON, C.C.: MITCHELL, T.J., GARDINER, D.A., KASTENBAUM, M.A., TOYA, R.E.: Secondary disease mortality in rat-mouse radiation chimeras. J. nat. Cancer Inst. 45, 1055 (1970).
DICKE, K.A.: Bone marrow transplantation after separation by discontinuous albumin density gradient centrifugation. Exp. Hemat. 20, 126 (1970).
ECKHARDT, A.: Über die Frage der Knochenmarkstransplantation. Orv. Hetil. 100, 1864 (1959).
EINSPRUCH, B.C.: Present status of marrow transplantation for Leukemia. Tex. St. J. Med. 56, 367 (1960).
EYRE, H.J., GOLDSTEIN, I.M., PERRY, S., GRAW, R.G., JR.: Leukocyte transfusion: Function of transfused granulocytes from donors with chronic myelocytic leukemia. Blood 36, 432 (1970).
FERREBEE, J.W., THOMAS, E.D.: Radiation injury and marrow replacement: Factors affecting survival of the host and the homograft. 39th Ann. Sess. Amer. Coll. of Physicans, Atlantic City/N.Y., May 1, 1958. Ann. Intern. Med. 49, 987 (1958).
FIALA, O., KASPAR, M., VORTEL, V.: Possibilities of intensive cytostatic therapy with transfer of autogenous bone marrow in sarcomas of the bone. Bratisl. lek. Listy 54, 452 (1970).
FURUSHO, K., NOZOE, N.: Bone marrow transplantation to a leukemic child with preparative treatment of large-dose of Prednisolone, Gold-Sol and 6-Mercaptopurine. Ann. pediat. jap. 13, 271 (1967).
GILBEY, D.B.: Liquid nitrogen and living cells. Bio-med. Eng. 1, 20 (1965).
GRAW, R.G., BROWN, J.A., YANKEE, R.A., LEVENTHAL, B.G., WHANG-PENG, J., ROGENTINE, G.N., JR., HENDERSON, E.S.: Transplantation of HL-A identical allogeneic bone marrow to a patient with acute lymphocytic leukemia. Blood 36, 736 (1970a).
GRAW, R.G., LEVENTHAL, B.G., YANKEE, R.A., ROGENTINE, G.N., WHANG-PENG, J., GINNIS, M.H., HERZIG, G.P., HALTERMAN, R.H., HENDERSON, E.S.: Hl-A and mixed leukocyte culture matched allogenic bone marrow transplantation in patients with acute leukemia. Transplantation Proceedings 13, 405 (1971).
GRAW, R.G., ROGENTINE, G.N., JR., LEBENTHAL, B.G., HALTERMAN, R.H., BERARD, C, HERZIG, G.P., YANKEE, R.A., WHANG-PENG, J., KRÜGER, G.: Graft-versus-host reaction complicating Hl-A matched bone-marrow transplantation. Lancet 1970 II, 1053 (b).
GRAW, R.G., WHANG-PENG, J., KRÜGER, G., BUCKNER, CD., LEVENTHAL, B.G., BERARD, C, HENDERSON, E.S.: Complication of bone marrow transplantation. Graft-versus-host disease resulting from chrnonic-myelo-genous leukemia leukocyte transfusion. Lancet 1970 II, 338 (c).
HALTERMAN, R.H., LEVENTHAL, B.G., GRAW, R.G., JR., YANKEE, R.A., ROGENTINE, G.N., JR., HERZIG, G.P., HENDERSON, E.S.: Immunocompen-tence of patients following HL-A matched bone marrow transplantation. Experimental Hematology Meeting, Pittsburgh:Penns., Nov. 13, 1970.
HOLT, J.A.G., WOODLIFF, H.J., DAVIS, R.E., NEAL, J.R.: Radiation and marrow infusion in leukemia. Observations on a patient with chronic granulocytic leukemia treated with whole-body radiation and infusion of isogenic marrow. Aust. Radiol. 11, 63 (1967).
ISHIBASHI, Y.: Cancer chemotherapy followed by homologous bone marrow transplantation. Acta haemat. jap. 24, 668 (1961).
JACOBSON, L.O., SIMMONS, E.L.: Comparison of the effects of isologous, homologous and heterologous hematopoietic tissues on post-irradiation survival. Radiology 75, 6 (1960).
KALINITSCHEWA, W.I., ROSANOWA, L.M., RAFALSON, D.I., NIKOLAJEWA, L.K.: Übertragung von Knochenmark zur Heilung schwerer Leukosen bei Kindern. Probleme der Hämatologie und Bluttransfusion, Bd. 2 (1961).
KAROW, A.M., WEBB, W.R.: Tissue freezing. A theory for injury and survival. Cryobiology 2, 99 (1965).
KASPAR, M., FIALA, O.: Cytostatic therapy of generalized forms of malignant tumours with transplantation of bone marrow. Bratisl. lekarske Listy 54, 435 (1970).
KOLAR, V., KADLECOVA, D.: Treatment of malignant tumours with high doses of nitrogen mustard (TS 160) and/or high doses of ionizing radiation under the protection of autologous bone marrow (evaluation after a period of 7 years). Neoplasma (Bratisl.) 17, 535 (1970).
KOLAR, A., MECHL, Z., SAKALOVA, J., SVABENIKOVA, L.: Attempt to treat malignant tumours with large doses of nitrogen mustard or X-rays and autologous bone marrow grafts. Folia biol. (Praha) 9, 34 (1963).
KORINTH, E.: Sterno-sternale Knochenmarkstransplantation und Chemotherapie bei myeloischen Leukämien. Münch. med. Wschr. 102, 2622 (1960).
KURNICK, N.B.: VIII. Intern. Congr. Hematol., Tokyo 1960.
KURNICK, N.B.: Summary of proceedings of the conference on chemical protection and bone marrow transplantation. Blood 16, 1499 (1960).
KURNICK, N.B., FEDER, B.H., MONTANO, A., GERDES, J.C., NAKAMURA, R.: Some observations on the treatment of postirradiation hematopoietic depression in man by the infusion of stored autogenous bone marrow. Ann. intern. Med. 51, 1204 (1959).
KURNICK, N.B., NOKAY, N.: Repopulation of the bone marrow in mice:
Number and type of cells required for post-X-irradiation protection. Radiat. Res. 25, 53 (1965).
KURNICK, J.E., WARD, H.P., SUVATTE, V.: Allogenic marrow infusion in aplastic anemia. Exp. Hematol. 20, 29 (1970).
LEVEY, R.H., GELFAND, E.W., BATCHELOR, J.R., KLEMPERER, M.R., SANDERSON, A.R., BERKEL, A.I., ROSEN, F.S.: Bone marrow transplantation in severe combined immunodeficiency syndrome. Lancet 1971, 571.
MALININ, T.I., PEGG, D.E., PERRY, V.P., BRODINE, C.E.: Long-term storage of bone marrow cells at liquid nitrogen and dry ice temperatures. Cryobiology 7, 65 (1970).
MATHE, G.: Transfusion et greffe de moelle osseuse homologue chez l’homme. Med. et Hyg. (Genève) 17, 491 (1959b).
MATHE, G.: Apllication of hematopoietic cell grafts to the treatment of leukemias and allied disease. A critical review. Blood 16, 1073 (1960).
MATHE, G., AMIEL, J.L., SCHWARZENBERG, L., CATTAN, A., SCHNEIDER, M., DE VRIES, M.J., TUBIANA, M., LALANNE, C, BINET, J.L., PAPIERNIK, M., SEMAN, G., MATSUKURA, M., MERY, A.M., SCHWARZMANN, V., FLAIS-LER, A.: Successful allogenic bone marrow transplantation in man: Chimerism, induced specific tolerance and possible anti-leukemic effects. Blood 25, 179 (1965).
MATHE, G., AMIEL, J.L., SCHWARZENBERG, L., CHOAY, J., TROLARD, P., SCHNEIDER, M., HAYAT, M., SCHLUMBERGER, J.R., JASMIN, C: Bone marrow graft in man after conditioning by antilymphatic serum. Brit. med. J. 5702/2, 131 (1970).
MATHE, G., AMIEL, J.L., SCHWARZENBERG, L., CHOAY, J., TROLAND, P., SCHNEIDER, M., HAYAT, M., SCHLUMBERGER, J.R., JASMIN, C: Bone marrow graft in man after conditioning by antilymphocytic serum. Transplantation Proceedings 3, 325 (1971).
MATHE, G., SCHWARZENBERG, L., LARRIEU, M.J.: Transfusion et greffe de moelle osseuse chez l’homme: Technique. Extrait du Sang, Tome 30, 784 (1959a).
MATHE, G., SCHWARZENBERG, L., DE VRIES, M.J., AMIEL, J.L., CATTAN, A., SCHNEIDER, M., BINET, J.L., TUBIANA, M., LALANNE, C., SCHWARZMANN, V., NORDMANN, R.: Les divers aspects du syndrome secondaire compliquant les transfusions allogéniques de moelle osseuse ou de leucocytes chez des sujets atteints d’héopathies malignes. Europ. J. Cancer 1, 75 (1965).
MCFARLAND, W., GRANVILLE, N.B., DAMESHEK, W.: Autologous bone marrow infusion as an adjuvant in therapy of malignant disease. Blood 14, 503 (1959).
MEYER, L.M., FLIEDNER, T.D., CRONKITE, E.P.: Autologous bone marrow transfusion following chemotherapy. Ann. N.Y., Acad. Sci. 114, 499 (1964).
MEZA, C, LARRAIN, C, OBERHAUSER, E., ASALGADO, N.: The treatment of cancer and lymphomas with massive dosis of nitrogen mustard and bone marrow transplants. Rev. med. Chile 90, 328 (1962).
MILLER, D.G.: Remission prolongée après irradiation X et transfusion de moelle osseuse chez un malade atteint de lymphosarcome. Revue franç. Étud., clin. biol. 10, 84 (1965).
MORTON, H.J., MORGAN, J.F., PARKER, R.C.: Nutrition of animal cells in tissue culture. Proc. Soc. exp. Biol. (N.Y.) 74., 22 (1950).
NEWTON, K.A., HUMBLE, J.G., WILSON, C.W., PEGG, D.E., SKINNER, M.E.G.: Brit. med. J. 1959 I, 531.
OWENS, A.H., SANTOS, G.W.: The induction of graft versus host disease in mice treated with Cyclophosphamide. J. exp. Med. 128, 277 (1968).
PEGG, D.E.: The hematological side effects of Caclophosphamide and a discussion of autologous bone marrow grafting after cancer chemotherapy. Cancer Chemother. Rep. 27, 39 (1963).
PEGG, D.E.: Freezing of bone marrow for clinical use. Cryobiology 1, 64 (1964).
PESCHL, L., REIMER, E.E.: Zur Anwendung hochdosierter zytostatischer Stoßtherapie und autologer KM-Übertragung bei malignen Erkrankungen des Lymphoretikulums. Krebsarzt 17, 147 (1962).
PHILLIPS, R.A., MILLER, R.G.: Physical separation of hemopoietic stem cells from cells involved in graft-versus-host disease. Exp. Hemat. 20, 7 (1970).
POLGE, C, SMITH, A.U., PARKES, A.S.: Revival of spermatozoes after vitrification and dehydration at low temperatures. Nature (London) 164, 666 (1949).
PUTTEN, L.M. VAN, BALNER, H., MULLER-BERAT, C.N., DE VRIES, M.J., BEKKUM, D.W. VAN: Progress in the treatment and prevention of secondary disease after homologous bone marrow transplantation in monkeys. Effects of chemotherapy and of donor selection by histocompatibility testing. In: Proc. 11th Congr. int. Soc. Blood Transf., Sidney 1966, Bibl. haemat. (Basel) 2, 574 (1968).
SANTOS, G.W.: Application of marrow grafts in human disease. Amer. J. Path. 65, 653 (1971).
SANTOS, G.W., SENSENBRENNER, L.L., BURKE, P.J., COLVIN, O.M., OWENS, S.H., JR., BIAS, W., SLAVIN, R.: Marrow transplants in man utilizing Cyclophosphamide: Summary of Baltimore experience. Exp. Hemat. 20, 78 (1970).
SANTOS, G.W., SENSENBRENNER, L.L., BURKE, P.J., COLVIN, M., OWENS, A.H., JR., BIAS, W.B., SLAVIN, R.E.: Marrow transplantation in man following Cyclophosphamide. Transplantation Proceedings 3, 400 (1971).
SEIDL, S., HEYDEN, V. VON DER, KNOCH, H., SONNEBORN, R.: Untersuchung zur Tiefkühlkonservierung von Blut. I. Die Verwendung niedriger Glyzerin-Konzentrationen bei Temperaturen von — 196C. Blut 20, 148 (1970).
SÖDERSTRÖM, N., NILLROTH, L.W.: Remissions following bone marrow transfusions in two cases of pancytopenia. Persönliche Mitteilung.
SPECK, B., DOOREN, L.J., KONING, J. DE, BEKKUM, D.W. VAN, BERNISSE, J.G., ELKERBOUT, F., VOSSEN, J.M., ROOD, J.J. VAN: Clinical experience with bone marrow transplantation: Failure and success. Transplantation Proceedings 3 409 (1971).
THOMAS, E.D., RUDOLPH, R.H., FEFER, A., STORB, R., SLICHTER, S., BUCKNER, C.D.: Insogeneic marrow grafting in man. Organisat. Meeting of the Exp. Hematol. Soc., Pittsburgh, Nov. 1970.
THOMAS, E.D., STORB, R.: Technique for human marrow grafting. Blood 36, 507 (1970).
THOMAS, E.D., STORB, R., FEFER, A., SLICHTER, S.J., BRYANT, J.I.,
BUCKNER, C.D., NEIMAN, P.E., CLIFT, R.A., FUNK, D.D., LERNER, K.E.: Aplastic anemia treated by marrow transplantation. Lancet 1972, 284.
TREMBLAY, E.C: Économie de transfusion dans les leucoses par les fractionnements Hématopoiétiques. Quelques observations particulièrement significatives. In: Proc. 7th Congr. Internat. Soc. Blood Transfusion, Rome 1958.
VADLAMUDI, S., PDARATHSINGH, M., BONMASSAR, E., GOLDIN, A.: Effect of combination treatment with cyclophosphamide and isogeneic or allogeneic spleen and bone marrow cells in leukemic (L1210) mice. Int. J. Cancer 7, 160 (1971).
WESTBURY, C, HUMBLE, J.G., NEWTON, K.A., SKINNER, M.E.G., PEGG, D.E.: Disseminated malignant melanoma. Response to treatment by massive dosage of a cytotoxic agent combined with autogenous marrow replacement. Lancet 1959, 968.
WITTE, S.: Die Behandlung der zytostatisch bedingten hämatologischen Nebenwirkungen durch Knochenmarktransfusion. Münch. med. Wschr. 102, 1251 (1960).
WYBRAN, P.J.: Étude de la conservation des lymphocytes en azote liquide. Nouv. Rév. franç. Hémat. 9, 627 (1969).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Karrer, K., Mannheimer, E. (1975). Autologe Knochenmarks-Transfusion bei hochdosierter Chemotherapie maligner Tumoren. In: Kärcher, K.H. (eds) Krebsbehandlung als interdisziplinäre Aufgabe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65936-2_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-65936-2_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-65937-9
Online ISBN: 978-3-642-65936-2
eBook Packages: Springer Book Archive