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Immunotherapy of Malignant Disease

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Geschwülste · Tumors I

Part of the book series: Handbuch der allgemeinen Pathologie ((1712,volume 6 / 5))

Zusammenfassung

The problem of cancer is the treatment of disseminated disease. Local lesions and strictly local spread can, in most cases, be adequately controlled by radiotherapy and surgery but with very few exceptions current treatments of cancer are unable to eradicate disseminated disease. This failure must be attributed to the lack of selectivity of radiotherapy and of the available forms of cancer chemotherapy. These cytotoxic agents are unable to discriminate between normal and malignant cells in an absolute sense. Consequently, any attempt at total elimination of disseminated cancer cells is lethal to the host due to the destruction of normal cells in vital organs. It is the prospect of achieving true selectivity that makes an immunological approach to the treatment of cancer attractive. This line of reasoning is not new and the first attempts at immunotherapy of human malignant disease were made nearly one hundred years ago. The realization that there was immunity to bacterial infections was quickly extended to tumours by making—without proof—the postulate that these possessed distinct antigens capable of eliciting host reactions. From 1880 onwards there swept across Europe a wave of cancer treatments with vaccines and sera. While the first attempts at the immunotherapy of cancer were not well documented, the response of a large series of patients to treatment with immune sera was described in 1895 (Hericourt and Richet).

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  1. Peter Alexander
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  1. Münster, Germany

    Ekkehard Grundmann

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Alexander, P. (1974). Immunotherapy of Malignant Disease. In: Grundmann, E. (eds) Geschwülste · Tumors I. Handbuch der allgemeinen Pathologie, vol 6 / 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65895-2_10

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