Association of Blood Flow and Acid-Base Change in Brain during Afferent Stimulation

  • L. G. Salford
  • T. E. Duffy
  • F. Plum


Since the experiments of Serota and Gerard (4) it has been known that stimulation of brain pathways induces a change in cerebral blood flow (CBF). However, the mechanism of the couple between the stimulus and the response is unknown. We have approached this problem by combining physiologic recordings with analysis of the respiratory gases in the cerebral arterial and venous blood. We also performed direct biochemical measurements on brain tissue.


Lactate Platinum Titration Pyruvate Bicarbonate 


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Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • L. G. Salford
  • T. E. Duffy
  • F. Plum

There are no affiliations available

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