Association of Blood Flow and Acid-Base Change in Brain during Afferent Stimulation

  • L. G. Salford
  • T. E. Duffy
  • F. Plum


Since the experiments of Serota and Gerard (4) it has been known that stimulation of brain pathways induces a change in cerebral blood flow (CBF). However, the mechanism of the couple between the stimulus and the response is unknown. We have approached this problem by combining physiologic recordings with analysis of the respiratory gases in the cerebral arterial and venous blood. We also performed direct biochemical measurements on brain tissue.


Cerebral Blood Flow Superior Sagittal Sinus Tail Artery Sinus Blood Physiologic Recording 
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  1. 1.
    Howse, D., Caronna, J., Duffy, T. E., Plum, F.: “Alterations in cerebral energy metabolism, brain pH, and cerebral blood flow during Indokloninduced seizures in the cat.” In Cerebral Circulation and Metabolism (this volume, p. 368).Google Scholar
  2. 2.
    Kaasik, A. E., Nilsson, L., and Siesjö, B. K.: “The effect of asphyxia upon the lactate, pyruvate, and bicarbonate concentration of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine and adenine nucleotides in anesthetized rats.” Acta Physiol. Scand. 78:433 (1970).PubMedCrossRefGoogle Scholar
  3. 3.
    Lowry, O. H., and Passonneau, J. V.: A Flexible System of Enzymatic Analysis. New York: Academic Press (1972).Google Scholar
  4. 4.
    Serota, H. M., Gerard, R. W.: “Localized thermal changes in cat’s brain.” J. Neurophysiol. 1:115 (1938).Google Scholar
  5. 5.
    Williamson, D. H., Lund, P., and Krebs, H. A.: “The redox state of free nicotinamide adenine dinucleotide in the cytoplasm and mitochondria of rat liver.” Biochem. J. 103:514 (1967).PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • L. G. Salford
  • T. E. Duffy
  • F. Plum

There are no affiliations available

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