Abnormalities of rCBF in Chronic Schizophrenia with Mental Deterioration
So far it has not been possible to find any specific morphological or biochemical changes in the brains of patients suffering from chronic schizophrenia. Furthermore, several studies have shown that the oxygen uptake and blood flow in this mental disorder are normal (5). Despite this, we have carried out rCBF studies in a group of chronic schizophrenics with a multi-detector system in order to investigate two problems: (1) whether the rCBF distribution in the dominant hemisphere at rest is normal, and (2) whether attempts at mental activation in highly deteriorated patients elicit activation patterns of the rCBF such as those seen in normals (3, 7). These problems have not been possible to study before.
KeywordsRegional Cerebral Blood Flow Chronic Schizophrenia Mental Deterioration Flow Level Dominant Hemisphere
Unable to display preview. Download preview PDF.
- 1.Gustafson, L., and Risberg, J.: “Regional cerebral blood flow related to psychiatric symptoms in dementia with onset in the presenile period.” Acta Psychiat. Scand. Submitted for publication, 1973.Google Scholar
- 2.Heath, R. G.: Studies in Schizophrenia. Cambridge, Mass.: Harvard University Press (1956).Google Scholar
- 5.Ingvar, D. H., and Franzen, G.: “Abnormalities of regional cerebral blood flow in patients with mental deterioration due to chronic schizophrenia.” J Psychiat. Res. Submitted for publication, 1973.Google Scholar
- 6.Lassen, N. A., and Ingvar, D. H.: “Radioisotopic assessment of regional cerebral blood flow.” Progr. Nucl. Med. 1:376 (1972).Google Scholar