Regional Cerebral Blood Flow. Evaluation of the Microsphere Technique

  • K. Shulman
  • M. Furman
  • R. Rosende


The present study describes a relatively simple technique for the resolution of regional flow in the cat using 15 ± 5 μ microspheres and the reference sample method of flow quantification. If one does not wish to measure cardiac output (5, 9, 10, 11) nor be concerned with residual isotope in syringe and tubing, it is possible to determine flow by employing an independent flow method to a reference organ (FK) and the radioactivity (CK) in that organ. Since the microsphere method implies that the ratio of flow and radioactivity will be the same in all organs, one can determine brain organ flow (FB) by measuring the activity of the entire brain (CB) and solving the equation
$$ {F_{{\left( B \right)}}} = {F_{{\left( K \right)}}} \times \frac{{{C_{{\left( B \right)}}}}}{{{C_{{\left( K \right)}}}}} $$


Regional Cerebral Blood Flow Pyridine Nucleotide Entire Brain Lactate Pyruvate Arterial Carbon Dioxide Tension 
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© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • K. Shulman
  • M. Furman
  • R. Rosende

There are no affiliations available

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