Effects of Local Increases of Venous Pressure on Canine Cerebral Hemodynamics
Increasing venous pressure locally while maintaining perfusion pressure constant is associated with a rise in precapillary resistance in several vascular beds (1, 3–6, 8, 9, 12, 13, 15, 16, 18–20, 22). This phenomenon has been labeled the venous-arteriolar response since it results from active vasoconstriction of precapillary vessels and is apparently independent of intrinsic or extrinsic neural control. The mechanism of this response is apparently myogenic (12), and it is thought to function physiologically to help maintain capillary hydrostatic pressure within normal limits during fluctuation in venous pressure (6, 12).
KeywordsCerebral Blood Flow Venous Pressure Cerebral Perfusion Pressure Transmural Pressure Renal Vascular Resistance
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