Interactions of Ionic Mechanisms in the Regulation of the Resistance of Pial Vessels
The most convincing arguments for the action of pharmacological, physiological, or pathological stimuli on the smooth muscle cells of brain vessels can be obtained by direct observations of the vascular diameters. To examine the local control mechanisms for the vascular resistance of pial vessels we combined local microperfusion of the extravascular space of small pial arteries and arterioles using mock CSF of various Ca++ and K+ concentrations and varying pH with electrical stimulation of the vessels by tiny electrodes attached directly to the outside of a vessel.
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