Mechanism of Action of Mitomycins

  • H. Kersten
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 38 / 2)


The mitomycins were discovered by Hata et al. (1956) in Streptomyces caespitosus and isolated by Wakaki et al. (1958) as deep violet crystals. Porfiromycin produced by Streptomyces ardus (DeBoer et al., 1961) also belongs to the group of mitomycin antibiotics. The two unidentified antibiotics, G 253 B and G 253 C, from Streptomyces reticuli var. shimofasuensis described by Hata et al. (1966) resemble the mitomycins in molecular weight, absorption spectra, and elemental analysis.


Thymidine Kinase Nitrogen Mustard Rous Sarcoma Virus Aziridine Ring Interstrand Crosslinking 
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