Strains of Streptomyces verticillus native to the soil of the coal mining country of Fukuoka Prefecture, Japan can elaborate heterogeneous antibiotic substances (i.e., phleomycin and bleomycin) with a capacity to block DNA synthesis, inhibit proliferation of replicative RNA’s, and prevent higher cells from entering meiotic or mitotic division. These actions can occur separately, possibly because they depend on different specific compounds present in phleomycin and bleomycin. These actions were discovered at different times and in different laboratories during independent investigations. Reported separately, they created a confusing and conflicting literature on the action of phleomycin-bleomycin.


Antineoplastic Agent Minor Groove Levulinic Acid Penile Cancer Receptor Unit 
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© springer-Verlag Berlin-Heidelberg 1975

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  • Paul Pietsch

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