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Altered Quantitative Expression of Immunoglobulin Allotypes in Rabbits

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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

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Abstract

In 1962, Dray showed that the quantitative expression of allelic allotypes in heterozygous rabbits was affected by exposure of the neonatal rabbits to maternal isoantibodies directed against the antigenic type inherited from the father (Dray, 1962). This phenomenon has become known as allotype suppression. During the decade since the discovery of the phenomenon, a considerable body of information has accumulated about the genetics, structure and localization of the genetically controlled antigenic variants of rabbit immunoglobulins (immunoglobulin allotypes) (reviewed by Mage et al., 1973a). This review will summarize our knowledge of allotype suppression in the light of current concepts of immunoglobulin structure and cellular immunology.

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Authors
  1. Rose G. Mage
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Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. Freiburg, Germany

    R. Haas

  3. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  4. Martinsried, Germany

    P. H. Hofschneider

  5. Copenhagen, Denmark

    O. Maaløe

  6. Gießen, Germany

    R. Rott

  7. Wilhelmshaven, Germany

    H. G. Schweiger

  8. Rehovot, Israel

    M. Sela

  9. Prague, Czech Republic

    L. Syruček

  10. Seattle, USA

    P. K. Vogt

  11. Würzburg, Germany

    E. Wecker

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Mage, R.G. (1974). Altered Quantitative Expression of Immunoglobulin Allotypes in Rabbits. In: Arber, W., et al. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65775-7_4

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