Abstract
This review has several purposes, (1) to cell attention to a newly defined form of surgically correctable hypertension and to describe in detail the components of this clinical syndrome, (2) to review the cases that have been published to date, and to mention several unpublished cases which have come to the attention of the author, (3) to outline present criteria which may lead to a preoperative diagnosis and (4) to discuss several’points of physiological interest which have evolved from careful study of this syndrome.
From the Department of Internal Medicine (Division of Endocrinology and Metabolism and the Metabolism Research Unit) University of Michigan Medical Center, Ann Arbor, Michigan 48104.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
CONN,J.W., COHEN,E.L., LUCAS,C.P., MCDONALD,W. J., MAYOR,G.H., BLOUGH,W.M., EVELAND,W. C., BOOKSTEIN, J. J., LAPIDES,J.: Hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors. Arch, intern. Med. 130, 682–696 ( 1972 ), ( Copyright 1972, American Medical Association).
ROBERTSON, P. W., KLIDJIAN,A., HARDING, L.K., WALTERS, G., LEE,M.R., ROBB-SMITH,A.H.T.: Hypertension due to a renin-secreting renal tumor. Amer. J. Med. 43, 963–976 (1967).
KIHARA,I., KITAMURA,S., HOSHINO,T., HITOSHI,S., WATANABE, T.: A hitherto unreported vascular tumor of the kidney: A proposal of “juxtaglomerula cell tumor”. Acta path. jap. 18, 197–206 (1968).
BONNIN, J.M., HODGE, R.L., LUMBERS, E. R.: A reninsecreting renal tumor associated with hypertension. Aust. N. Z. J. Med. 2, 178–181 (1972).
SCHAMBELAN, M., HOWES, E.L., Jr., STOCKIGT, J. R., NOAKES,C.A., BIGLIERI,E.G.: Role of renin and aldosterone in hypertension due to a renin-secreting tumor. Amer. J. Med. 55, 86–92 (1973).
CONN et al. (unpublished).
HIROSE,M., ARAKAWA,K., KAWASAKI, K., OMOTO, T., KIKUCH,M., KATO,H., NAGA-YAMA,T.: A case of primary reninism with a strange renal histology (in preparation, Fukuoka, Japan).
MACCALLUM, D. K., CONN, J. W., BAKER, B.L.: Ultrastructure of a renin-secreting juxtaglomerular cell tumor of the kidney. J. invest. Urology (in press).
VOUTE,P.A., Jr., VAN DER MEER, J., STAUGART-KLOOSTERZIEL,W.: Plasma renin activity in wilms’ tumor. Acta Endocr. 67, 197–202 (1971).
MITCHELL,J.D., BAXTER,T.J., BLAIR-WEST,J.R., MCCREDIE,D.A.: Renin levels in nephroblastoma (wilms’ tumor). Arch. Dis. Child. 45, 376–384 (1970).
LUETSCHER, J.A., GANGULY,A., GRIBBLE, J.T., KEMPSON,R.L., TUNE,B.: To be published. Personal communication, September 29, 1972.
MAROSVARI, KONTOR,I.E., KALLAY,K.: Renin-secreting WILMS’ tumor. Lancet 19721, 1180.
SPERGEL,G., BORIS,L., LEVY,L. J., ERTEL,N.H.: Studies of hypertension and carbohydrate intolerance associated with wilms’ tumor. Ann. intern. Med. 70, 565–569 (1969).
EDDY,R.L., SANCHEZ, S. A.: Renin-secreting renal neoplasm and hypertension with hypokalemia. Ann. intern. Med. 75, 725–729 (1971).
COHEN, E.L., CONN, J. W., LUCAS, C. P., MCDONALD, W. J., GRIM,C.E., MAYOR, G.H., SALTMAN,S.E., CALDWELL, J.W.: Radioimmunoassay for angiotensin I: Measurement of plasma renin activity, plasma renin concentration, renin substrate concentration, and angiotensin I, in normal and hypertensive people. In: GENEST,J., Koiw,E. (Eds.): Hypertension “72”, pp. 569–582. Berlin-Heidelberg-New York: Springer 1972.
PINCOFFS,M.C., BRADLEY, J. E.: The association of adenosarcoma of the kidney (wilms’ tumor) with arterial hypertension. Trans. Ass. Amer. Phys. 52, 320.
BRADLEY, J. E., PINCOFFS,M.C.: The association of adenomyosarcoma of the kidney (WILMS’ tumor) with arterial hypertension. Ann. intern. Med. 11, 1613.
DANIEL,W.E.: The hypertensive factor in wilms’ tumor. S. Afr. med. J. 32, 1014
BRADLEY, J. E., DRAKE,M.E.: The effect of preoperative roentgen-ray therapy on arterial hypertension in embryoma (kidney). J. Pediat. 35, 710.
WALDHAUSL,W.K., LUCAS, C. P., CONN, J. W., LUTZ,J.H., COHEN, E.L.: Studies on the partial isolation of human renin. Biochim. biophys. Acta (Amst.) 221, 536–548 (1970).
BARAJAS,L.: The development and ultrastructure of the juxtaglomerular cell granule. J. ultrastruct. Res. 15, 400–413 (1966).
BIAVA, C. G., WEST,M.: Fine structure of normal human juxtaglomerular cells: II. Specific and nonspecific cytoplasmic granules. Amer. J. Path. 49, 955–979 (1966).
BLAIR-WEST, J. R., CAIN,M., CATT,K., COGHLAN, J. P., DENTON,D. A., FUNDER,J.W., SCOGGINS,B. A., WRIGHT, R.D.: Inhibition of renin secretion by systemic and intra- adrenal angiotensin infusion. J. Physiol. (Lond.) 220, 1309–1315 (1971).
VANDER,A. J.: Control of renin release. Physiol. Rev. 47, 359–382 (1967).
ROBB-SMITH,A.H.T.: Renin-secreting kidney tumors. Lancet 1971 II, 493.
BUHLER, F. R., BAER,L., VAUGHAN,E.D., BRUNNER,H.R., LARAGH, J.H.: Inhibition of renin secretion by propranolol: A specific treatment for renal hypertension? (abstracted). Amer. Soc. Clin. Invest., p. 17a. 64th Annual Meeting, Atlantic City, N. J., (May 1, 1972 ).
SCHAUDEL, P. J., BEVERIDGE, J., STOKES, G. S.: Increased plasma renin activity, secondary aldosteronism, and hypertension. Amer. J. Dis. Child 119, 159–163 (1970).
BROWN,J. J., FRASER,R., LEVER,A.F., MORTON,J. J., ROBERTSON,J.I.S.: Primary excess and deficiency of renin. In: Eisenbach,G.M. (Ed.): Proceedings of the First Symposium of Nephrology at Hannover 1973. Med. School, Hannover, Germany 1973.
Editor information
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Conn, J.W. (1974). Primary Reninism, A Surgically Curable Form of Hypertension. In: Frick, P., von Harnack, GA., Martini, G.A., Prader, A., Schoen, R., Wolff, H.P. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde. Ergebnisse der Inneren Medizin und Kinderheilkunde. Neue Folge Advances in Internal Medicine and Pediatrics, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65746-7_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-65746-7_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-65748-1
Online ISBN: 978-3-642-65746-7
eBook Packages: Springer Book Archive