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Muscle Relaxants and Respiration

  • F. F. Foldes
Conference paper
Part of the Anaesthesiology and Resuscitation / Anaesthesiologie und Wiederbelebung / Anesthésiologie et Réanimatión book series (A+I, volume 80)

Abstract

Muscle relaxants may influence respiration by depressing the respiratory center, inhibiting neuromuscular (n. m.) transmission of the respiratory muscles, or altering airway resistance and/or compliance. Of these three possibilities the first and the third are relatively unimportant from the clinical point of view and require only brief consideration.

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References

  1. 1.
    Bendixen, H. H., Surtees, A. D., Oyama, T., Bunker, J. P.: Postoperative disturbances in Ventilation following the use of muscle relaxants in Anesthesia. Anesthesiology 20, 121 (1959).CrossRefGoogle Scholar
  2. 2.
    Christie, T. H., Churchill-Davidson, H. C.: The St. Thomas’ Hospital nerve stimulator in the diagnosis of prolonged apnoea. Lancet 1, 776 (1958).PubMedCrossRefGoogle Scholar
  3. 3.
    Churchill-Davidson, H. C.: A portable peripheral nerve-stimulator. Anesthesiology 26, 224 (1965).PubMedCrossRefGoogle Scholar
  4. 4.
    Comroe, J. H., Dripps, R. D.: The histamine-like action of curare and tubocurarine injected intracutaneously and intra-arterially in man. Anesthesiology 7, 260 (1946).PubMedCrossRefGoogle Scholar
  5. 5.
    Corrado, A. P.: Respiratory depression due to antibiotics: calcium in treatment. Anesth. Analg. Curr. Res. 42, 1 (1963).Google Scholar
  6. 6.
    Dripps, R. D., Severinghaus, J. W.: General anesthesia and respiration. Physiol. Rev. 35, 741 (1955).PubMedGoogle Scholar
  7. 7.
    Doughty, A. G., Wylie, W. F.: Antidotes to “true” curarizing agents including a report on RO2–3198 (Tensilon). Brit. J. Anaesth. 24, 67 (1952).CrossRefGoogle Scholar
  8. 8.
    Dundee, J. W.: Influence of controlled respiration on dosage of thiopentone and d-tubocurarine chloride required for abdominal surgery. Brit. med. J. 2, 893 (1952).PubMedCrossRefGoogle Scholar
  9. 9.
    Elam, J. O.: A method of maximally assisted ventilation. Int. Anes. Clin. 3, 297 (1965).CrossRefGoogle Scholar
  10. 10.
    Ellis, C. H., Morgan, W. V., De Beer, E. J.: Central depressant actions of certain myoneurol blocking agents. J. Pharmacol. exp. Ther. 106, 353 (1952).PubMedGoogle Scholar
  11. 11.
    Fellini, A. A., Bernstein, R. L., Zauder, H. L.: Bronchospasm due to suxamethonium. Brit. J. Anaesth. 35, 657 (1963).PubMedGoogle Scholar
  12. 12.
    Foldes, F. F.: The use of mytolon chloride in anesthesiology. Ann. N. Y. Acad. Sci. 54, 503 (1951).PubMedCrossRefGoogle Scholar
  13. 13.
    Foldes, F. F., Baarr, N., Shanor, S. P., Erdos, E. G.: The inhibitory effect of neuromuscular blocking agents and their antagonists on human cholinesterase s. Anesthesiology 18, 163 (1957).CrossRefGoogle Scholar
  14. 14.
    Foldes, F. F.: Narcotic-induced controllable apnea. Amer. J. med. Sci. 233, I (1957).Google Scholar
  15. 15.
    Foldes, F. F.: Factors which alter the effects of muscle relaxants. Anesthesiology 20, 464 (1959).PubMedCrossRefGoogle Scholar
  16. 16.
    Foldes, F. F.: Remarks on the potentiation of succinylcholine by hexafluorenium. Anesth. Analg. Curr. Res. 39, 47 (1960).Google Scholar
  17. 17.
    Foldes, F. F.: The pharmacology of neuromuscular blocking agents in man Clin. Pharmacol Ther. 1, 345 (1960).Google Scholar
  18. 18.
    Foldes, F. F.: The human pharmacology and clinical use of narcotic antagonists. Med. Clin. N. Amer. 48, 421 (1964).PubMedGoogle Scholar
  19. 19.
    Foldes, F. F., Advantages and disadvantages of assisted and controlled respiration during anesthesia. Proc. Internat’l. Anesthesiology Symp., Prague, p. 158, 1965.Google Scholar
  20. 20.
    Foldes, F. F., The Choice and Mode of Administration of Relaxants. In: Foldes, F. F. (Ed.): Muscle Relaxants, Clinical Anesthesia, p. 1. Philadelphia: F. A. Davis Co. 1966.Google Scholar
  21. 21.
    Foldes, F. F., Duncalf, D., Robbins, R. S., D’Sovza, P. B., Conte, A. A.: Production of controllable apnea in anesthesia. J. Amer. med. Ass. 166, 325 (1958).Google Scholar
  22. 22.
    Foldes, F. F., Monte, A. P., Bruinent, H. M., Wolfson, B.: Studies with muscle relaxants in unanesthetized subjects. Anesthesiology 22, 230 (1961).PubMedCrossRefGoogle Scholar
  23. 22.
    Foldes, F. F., Monte, A. P., Bruinent, H. M., Wolfson, B.: The influence of exercise on the neuromuscular activity of relaxant drugs. Canad. Anaesth. Soc. J. 8, 118 (1961).PubMedCrossRefGoogle Scholar
  24. 24.
    Foldes, F. F., Swerdlow, M., Siker, E. S: Narcotcis and Narcotic Antagonists. Springfield, Ill.: Charles C. Thomas 1964.Google Scholar
  25. 25.
    Foldes, F. F., Duncalf, F., Kuwabara, S.: The respiratory, circulatory, and narcotic antagonistic effects of nalorphine, levallorphan and naloxone in anaesthetized subjects. Canad. Anaesth. Soc. J. 16, 152 (1969).CrossRefGoogle Scholar
  26. 26.
    Foldes, F. F., Klonymus, D. H., Maisel, W., Sciammas, F., Pan, T.: Studies of Pancuronium in Conscious and Anesthetized Man. Anesthesiology 35, 496 (1971).PubMedCrossRefGoogle Scholar
  27. 27.
    Gray, T. C.: Curare and relaxant drugs. In: British Encyclopaedia of Medical Practice, ed. 2, p. 78. London: William Blackwood and Sons, Ltd. 1950.Google Scholar
  28. 28.
    Harvey, A. M.: The action of quinine methochloride on neuromuscular transmission. Bull. Johns Hopk. Hosp. 66, 52 (1940).Google Scholar
  29. 29.
    Hunter, A. R.: Tensilon: A new anticurare agent. Brit. J. Anaesth. 24, 175 (1952).PubMedCrossRefGoogle Scholar
  30. 30.
    Landmesser, C. M., Converse, J. G., Harmel, M. H.: Quantitative Evaluation of the Bronchoconstrictor Action of Curare in the Anesthetized Patient: A Preliminary Report. Anesthesiology 13, 275 (1952).PubMedCrossRefGoogle Scholar
  31. 31.
    Massion, W. H., White, J. M.: The effect of anesthesia and muscle relaxants on the elastic properties of the human thorax. Anesthesiology 20, 134 (1959).CrossRefGoogle Scholar
  32. 32.
    Papadopoulos, C. N., Keats, A. S.: Specific and nonspecific antagonism of morphine-induced respiratory depression. Anesthesiology 23, 86 (1962).PubMedCrossRefGoogle Scholar
  33. 33.
    Paton, W. D. M., Zaimis, E. J.: The methonium compounds. Pharmacol. Rev. 4, 219 (1952).PubMedGoogle Scholar
  34. 34.
    Pittinger, C. B.: Antagonists of Muscle Relaxants. In: Artusio, J. F., Jr., M. D. (Ed.): Clinical Anesthesia, p. 95. Philadelphia: F. A. Davis Co. 1966.Google Scholar
  35. 35.
    Rees, L. T., Davidson, M. H. A.: Suxamethonium and respiration. Investigation of a possible central action of suxamethonium chloride during clinical anaesthesia. Anesthesia 12, 57 (1957).CrossRefGoogle Scholar
  36. 36.
    Robertazzi, R. W.: Discussion of paper on “The use of mytolen chloride in anesthesiology” by FOLDES, F. F. Ann. N. Y. Acad. Sci. 54, 509 (1951).Google Scholar
  37. 36a.
    Rosner, V., Kepes, E. R., Foldes, F.F.: The effects of atropine and neostigmine on heart rate and rhythm: Recommendation for their use to reverse residual neuromuscular block. Brit. J. Anaesth. 43, 1066 (1971).PubMedCrossRefGoogle Scholar
  38. 37.
    Safar, P., de Kornfeld, T. J.: Effects of d-tubocurarine and gallamine on the lungs and circulation in dogs and man. Proceedings of the Internat’l. Symp. on Curare and Curare-like Agents, Venice, Italy, p. 346. Sept. 12, 1958.Google Scholar
  39. 38.
    Selvin, B., Howland, W. S.: Bronchospasm associated with the use of a combination of succinylcholine and mylaxen to produce muscular relaxation. Anesth. Analg. Curr. Res. 38, 332 (1959).Google Scholar
  40. 39.
    Smith, N. L.: Histamine release by suxamethonium. Anaesthesia 12, 293 (1957).PubMedCrossRefGoogle Scholar
  41. 40.
    Smith, J. C., Foldes, V. M., Foldes, F. F.: Distribution of cholinesterase in normal human muscle. Canad. J. Biochem. 41, 1713 (1963).PubMedCrossRefGoogle Scholar
  42. 41.
    Stovner, J., Lund, I.: Dose-response curves for tubocurarine, alloferine and pancuronium. Acta anaesth. scand. Suppl. 37, 238 (1970).Google Scholar

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© Springer-Verlag Berlin Heidelberg 1974

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  • F. F. Foldes

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