Oxygen Pneumonitis in Man

A Summary of Histological, Ultrastructural and Morphometric Findings
  • Y. Kapanci
  • R. Tosco
  • J. Eggermann
  • V. E. Gould
Conference paper
Part of the Anaesthesiology and Resuscitation / Anaesthesiologie und Wiederbelebung / Anesthésiologie et Réanimatión book series (A+I, volume 80)


During the last 10 years, because of extensive development of intensive care medicine and the use of artificial atmosphere in space travel, the interest in lung lesions produced by high concentrations of oxygen breathing has been continuously increasing. The early studies of Pratt [1] and later those of Nash et al. [2] demonstrated alveolar damage in patients given high concentrations of oxygen. A detailed description of our findings is given in three recent articles [3, 4, 5].


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  1. 1.
    Pratt, P. C.: Pulmonary capillary prc liferation induced by oxygen inhalation. Amer. J. Path. 34, 1033–1049 (1958).PubMedGoogle Scholar
  2. 2.
    Nash, G., Blennerhassett, J. B., Pantoppidan, H.: Pulmonary lesions associated with oxygen therapy and artificial ventilation. New Engl. J. Med. 276, 368–374 (1967).Google Scholar
  3. 3.
    Kapanci, Y., Weibel, E. R., Kaplan, H. P., Robinson, F. R.: Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies. Lab. Invest. 20, 101–118 (1969).PubMedGoogle Scholar
  4. 4.
    Gould, V. E., Tosco, R., Wheelis, R., Gould, N. S., Kapanci, Y.: Oxygen Pneumonitis in man. Ultrastructural observations on the development of alveolar lesions. Lab. Invest. 26, 499–508 (1972).PubMedGoogle Scholar
  5. 5.
    Kapanci, Y., Tosco, R., Eggerman, J., Gould, V. E.: Oxygen pneumonitis in man. Light and electron microscopic morphometric studies. Chest 62, 162–169 (1972).PubMedCrossRefGoogle Scholar
  6. 6.
    Caldwell, P. R. B., Lee, W. H., Schildkraut, H. S., Archibald, E. R.: Changes in lung volume diffusion capacity and blood gases in men breathing oxygen. J. appl. Physiol. 21, 1477–1483 (1966).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1974

Authors and Affiliations

  • Y. Kapanci
  • R. Tosco
  • J. Eggermann
  • V. E. Gould

There are no affiliations available

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