Abstract
Increasing experimental and clinical evidence has been accumulated on the efficacy of steroids in the treatment of brain edema since the first reports of GALICICH and FRENCH in 1961. Based on a large clinical study, this group showed that dexamethasone often resulted in the rapid and dramatic relief of symptoms and signs of increased intracranial pressure and neurological dysfunction associated with cerebral edema (11, 12,20). Since this enthusiastic report subsequent workers were able to demonstrate the correctness of most of these statements, using more refined techniques. The present report is an attempt to summarize these recent findings and to evaluate critically this mode of treatment of brain edema.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
BAETHMANN, A., A. van HARREVELD: Physiolgical and biochemical findings in the central nervous system of adrenalectomized rats and mice. In: Steroids and Brain Edema, pp 195–202, Berlin-Heidelberg-New York, Springer 1972
BAETHMANN, A.: Pathophysiology of cerebral edema, chemical aspects. Vortrag Kongress Deutsche Gesellschaft für Neurochirurgie in Mainz, April/ Mai 1973
BEKS, J. W. F., H. DOORENBOS, G. J. M. WALSTRA: Clinical experiences with steroids in neurosurgical patients. In: Steroids and Brain Edema, pp 233–238, Berlin-Heidelberg-New York, Springer 1972
BROCK, M., A. HADJIDIMOS, J. P. DERUAZ, and K. SCHüRMANN: Regional cerebral blood flow and vascular reactivity in cases of brain tumor. In: Brain and Blood Flow, oo 281–284, London, Pittman Medical and Scientific Publishing & Co. 1971
BUCY, T. C. and P. K. IELSMA: The treatment of glioblastoma multiforme. Excerpta Med. Int. Congr. Series, No. 193 (1969)
CANTU, R. U., H. AMIR-AHMADI and A. PRIETO: Evaluation of the increased risk of gastro-intestinal bleeding following intracranial surgery in patients receiving high steroid dosages in the immediate post-operative period.. Int. Surg. Dig. 50, 325–335 (1968)
FEIGIN, I., and M. ADACHI: Cerebral oedema and the water content of normal white matter. J. Neurol. Neurosurg. Psychiatr. 29, 446–450, (1966)
FEIGIN, J., G. BUDZILOVICH and J. OGATA: Edema of the grey matter of the human brain. J. Neuropath, exp. Neurol. 30., 206–215, (1971)
FREI, H. J., Th. WALLENFANG, W. PöLL, H. J. FREI, R. SCHUBERT and M. BROCK: Regional cerebral blood flow and regional metabolism in cold induced brain edema. Acta Neurochirurg. (in press).
FRENCH, L. A. and J. H. GALICICH: The use of steroids for control of cerebral edema. Clinical Neurosurgery, 212–223 (1964)
GALICICH, J. H., A. A. FRENCH and J. C. MELBY: Use of dexamethasone in treatment of cerebral edema associated with brain tumors. J. Lancet, 31, 46–53 (1961)
GALICICH, J. H. and L. A. FRENCH: Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery. Amer. Practit, 12, 169–174 (1961)
HADJIDIMOS, A., M. BROCK, M. HADJIDIMOS, J. P. DERUAZ and K. SCHüRMANN: Die fokale und perifokale örtliche Hirndurchblutung bei cerebralen Tumoren. Prognostische Möglichkeiten durch Vergleich prä- und postoperativer Befunde im extratumoralen Hirngewebe. In: Ergebnisse der klinischen Nuklearmedizin, pp, 1020–1029, Stuttgart-New York, Schattauer 1971
HADJIDIMOS, A., U. STEINGASS, F. FISCHER, H. J. REULEN and K. SCHüRMANN: The effects of dexamethasone on rCBF and cerebral vasomotor response in brain tumors. Preliminary Communication, Europ. Neurol., 10, 25–30,(1973)
HERRMANN, H. D., D. NEUENFELDT, J. DITTMANN and H. PALLESKE: The influence of dexamethasone on water content, electrolytes, BBB and glucose metabolism in cold injury edema. In: Steroids and Brain Edema, pp, 77–85, Berlin-Heidelberg-New York, Springer 1972
KULLBERG, G.: Clinical studies on the effect of corticosteroids on the ventricular fluid pressure. In: Steroids and Brain Edema, pp 253–258, Berlin-Heidelberg-New York, Springer 1972
KLATZO, I.: Pathological Aspects. Vortrag Kongress Deutsche Gesellschaft für Neurochirurgie im Mainz, April/Mai 1973
LASSEN, N. A.: The luxury perfusion syndrome and its possible relation to acute metabolic acidosis localized within the brain. Lancet 2, 1113–1115 (1966)
LONG, D. M., J. F. HARTMANN and L. A. FRENCH: The response of human cerebral edema to glucosteroid administration. Neurology, 16, 521–528 (1966).
MAXWELL, R. E., D. M. LONG and L. A. FRENCH: The clinical effects of a synthetic gluco-corticoid used for brain edema in the practice of neurosurgery In: Steroids and Brain Edema, pp 219–232, Berlin-Heidelberg-New York: Springer 1972
MAXWELL, R. E., D. M. LONG and L. A. FRENCH: The effects of glucosteroids upon cold-induced brain edema. In: Gross morphological and vascular permeability changes. J. Neurosurg. 34, 477–487 (1971)
MEINIG, G., H. J. REULEN and Ch. MAGAWLY: Regional cerebral blood flow and cerebral perfusion pressure in global cerebral edema induced by water intoxication. Acta neurochirurg. (in press)
MÜCKE, R.: Discussion in: Steroids and Brain Edema, pp 282–283, Berlin-Heidelberg-New York, Springer 1972
PALVÖGYI, R.: Regional cerebral blood flow in patients with cerebral tumors J. Neurosurg. 31, 149–163 (1969)
RANSOHOFF, J.: The effects of steroids on brain edema in man. In: Steroids and Brain Edema, pp 211–217, Berlin-Heidelberg-New York, Springer 1972
REULEN, H. J., A. HADJIDIMOS, and K. SCHÜRMANN: The effect of dexamethasone on water and electrolyte content and on rCBF in perifocal brain edema in man. In: Steroids and Brain Edema, pp 239–252, Berlin-Heidelberg-New York, Springer 1972
REULEN, H. J. and H. G. KREYSCH: Measurement of brain tissue pressure in cold induced brain edema. Acta Neurochir. (in press)
REULEN, H. J., F. MEDZIHRADSKY, R. ENZENBACH, F. MARGUTH and W. BRENDEL: Electrolytes, fluids and energy metabolism in cerebral edema in man. Arch, Neurol. 21, 517–525 (1969)
SCHMIEDEK, P., A. BAETHMANN, E. SCHNEIDER, W. ÖTTINGER, R. ENZENBACH, F. MARGUTH and W. BRENDEL: The effect of aldosterone and an aldosterone antagonist on the metabolism of perifocal brain edema in man. In: Steroids and Brain Edema, pp. 203–210, Berlin-Heidelberg-New York, Springer, 1972
Sparachio, R., T. H. Linn and A. W. Cook: Methylprednisolone sodium succinate in acute craniocerebral trauma. Surg. Gynecol. Ostetr. 121,1– 516, (1965)
STEWARD-WALLACE, A. M.: A biochemical study of cerebral tissue and of the changes in cerebral edema. Brain, 62, 426–438, (1939)
WITHROW, C. D. and D. M. WOODBURY: Some aspects of the pharmacology of adrenal steroids and the central nervous system. In: Steroids and Brain Edema, pp 41–55, Berlin-Heidelberg-New York, Springer 1972
ZüLCH, K. J.: Hirnschwellung und Hirnödem. Dtsch. Zschr. Nervenheilk. 170, 179–208 (1953)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Reulen, H.J., Hadjidimos, A., Hase, U. (1973). Steroids in the Treatment of Brain Edema. In: Schürmann, K., Brock, M., Reulen, HJ., Voth, D. (eds) Brain Edema / Cerebello Pontine Angle Tumors. Advances in Neurosurgery, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65734-4_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-65734-4_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-06486-2
Online ISBN: 978-3-642-65734-4
eBook Packages: Springer Book Archive