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Initiation of Protein Synthesis in Prokaryotes

  • Conference paper
Regulation of Transcription and Translation in Eukaryotes

Abstract

Initiation of protein synthesis appears to be a process of great complexity in both prokaryotic and eukaryotic systems. A possible reason for such complexity, particularly in comparison with the process of elongation of nascent proteins, may reside in gene regulation operating through the selection of mRNA or cistrons by ribosomes and protein factors. It is known that in prokaryotes the main control occurs at the transcriptional level. However, for polycistronic mRNA’s there are a few facts consistent with a regulation at the translational level, and this is particularly shown in the case of RNA phage infection of E. coli (MS2, Qß, R17) where the three cistrons of the phage RNA are translated with different frequencies in vivo [1] although they are present in equal concentrations. Therefore, it is conceivable that a control exists at the translational level which might have a specific function in fine regulation of bacterial protein synthesis.

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Author information

Authors and Affiliations

  1. Institut de Biologie Physico-chimique, Paris, France

    M. Grunberg-Manago, Th. Godefroy-Colburn, A. D. Wolfe, P. Dessen, D. Pantaloni, M. Springer, M. Graffe, J. Dondon & A. Kay

  2. Laboratoire d’Enzymologie du C.N.R.S., Gif-sur-Yvette, France

    P. Dessen & D. Pantaloni

Authors
  1. M. Grunberg-Manago
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  2. Th. Godefroy-Colburn
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  3. A. D. Wolfe
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  4. P. Dessen
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  5. D. Pantaloni
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  6. M. Springer
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  7. M. Graffe
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  8. J. Dondon
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  9. A. Kay
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Editor information

Editors and Affiliations

  1. Institut für Molekulare Genetik, Zoologisches Institut der Universität, D-6900, Heidelberg, Neuenheimer Feld, Federal Republic of Germany

    E. K. F. Bautz

  2. Physiologisch-Chemisches Institut der Universität, D-3550, Marburg, Federal Republic of Germany

    P. Karlson

  3. Physiologisch-Chemisches Institut der Universität, D-8520, Erlangen, Federal Republic of Germany

    H. Kersten

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© 1973 Springer-Verlag Berlin · Heidelberg

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Grunberg-Manago, M. et al. (1973). Initiation of Protein Synthesis in Prokaryotes. In: Bautz, E.K.F., Karlson, P., Kersten, H. (eds) Regulation of Transcription and Translation in Eukaryotes. Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1973 in Mosbach/Baden, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65725-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-65725-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65727-6

  • Online ISBN: 978-3-642-65725-2

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