Abstract
In some aspects mitochondria behave like endosymbiontic bacterial cells because they proliferate by division, growth and distribution to the progeny [1, 2] and because they contain a circular genome which is replicated and expressed by a mitochondrion-specific genetic apparatus of bacterial nature [3]. However, this genome is at least ten times smaller than the genome of the smallest free-living cells like Mycoplasm. The mitochondrion is therefore far from being autonomous in the genetic sense but depends heavily on nuclear genes of its “host” cell for growth and reproduction. The proteins of the outer membrane and the matrix seem all to be determined by nuclear genes and to be synthesized on cytoplasmic ribosomes whereas the biosynthesis of the inner membrane is controlled by both nuclear and mitochondrial genes [4].
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Küntzel, H., Barath, Z., Ali, I., Kind, J., Althaus, H.H., Blossey, H.C. (1973). Expression of the Mitochondrial Genome in Wild Type and in an Extranuclear Mutant of Neurospora Crassa . In: Bautz, E.K.F., Karlson, P., Kersten, H. (eds) Regulation of Transcription and Translation in Eukaryotes. Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1973 in Mosbach/Baden, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65725-2_11
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DOI: https://doi.org/10.1007/978-3-642-65725-2_11
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