Zusammenfassung
Schaumzellen sind Makrophagen mit fremdem Inhalt. Sie kommen bei manchen Krankheiten vor und erscheinen im Paraffinschnitt als große Zellen mit hellem, körnigem oder „schaumigem“Zytoplasma und einem kleinen Kern. Im allgemeinen ist es nicht möglich, am Paraffinschnitt den Inhalt dieser Zellen und damit ihre Bedeutung abzuklären. Im folgenden wird eine Zusammenstellung generalisierter Prozesse, oft metabolischer Art, präsentiert. Damit sind alle lokalisierten Prozesse ausgeschlossen, wie z.B. echte Tumoren (Hypernephrom, alveoläres Weichteilsarkom, Myxom), Knochenveränderungen des Typs fibröse Dysplasie, nicht ossifizierende Fibrome sowie in den Nieren auftretende Schaumzellen lokalen Ursprungs, die bei vielen Krankheiten vorkommen können (Zollinger und Rohr, 1969).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Kamoshita, S., Landing, B. H.: Distribution of lesions in myenteric plexus and gastrointestinal mucosa in lipidoses and other neurological disorders in children. Amer. J. clin. Path. 49, 312 (1968).
Wolman, M.: Histochemistry of lipids in pathology. In Handbuch der Histochemie (Hrsg. Graumann & Neumann), vol. V: 2. Stuttgart: Gustav Fischer 1964.
Wolman, M.: Pigments in Pathology. New York: Academic Press 1969.
Yunis, E., Sherman, F. E.: Macrophages of the rectal lamina propria in children. Amer. J. clin. Path. 53, 580 (1970).
Zollinger, H. U., Rohr, H.-P.: Struktur und Bedeutung der renalen Schaumzellen. Vir-chows Arch. Abt. A 348, 205 (1969).
Ceroid
Fisher, E. R.: Pigmentation of intestinal tract. In Pigments in Pathology (Hrsg. Wolman, M.), S. 489. New York: Academic Press 1969.
Fisher, E. R., Hellström, H. R.: Ceroid-like colonic histiocytosis. Amer. J. clin. Path. 42, 581 (1964).
Oppenheimer, E., Andrews, Jr., E. A.: Ceroid storage disease in childhood, Pediatrics 23, 1091 (1959).
Chronische Granulomatose
Barnes, R. D., Bishun, N. P., Holliday, J.: Impaired lymphocyte transformation and chromosomal abnormalities in fatal granulomatous disease of childhood. Acta paediat. scand. 59, 403 (1970).
Clawson, C. C., Rodey, G. E., Good, R. A.: Ultrastructure of familial lipochrome histiocytosis. Lab. Invest. 22, 294 (1970).
Eschenbach, C.: Zur Aetiologie der progressiven septischen Granulomatose. Pediat. Res. 4, 493 (1970).
Eschenbach, C., Seebach, G.: Anomalie der Lysosomenmembran von neutrophilen Granu-locyten als Ursache der progressiven septischen Granulomatose. Virchows Arch. Abt. B 7, 16 (1971).
Heyne, K.: Progressive septische Granulomatose (chronic granulomatous disease) im Säuglingsalter. Acta paediat. Acad. Sci. hung. 12, 137 (1971).
Hitzig, W. H., Molz, G., Plüss, H. J., Renner, R.: Progressive septische Granulomatose. Helv. paediat. Acta 24, 246 (1969).
Johnston, R. B., Baehner, R. L.: Chronic granulomatous disease: Correlation between pathogenesis and clinical findings. Pediatrics 48, 730 (1971).
Krěpela, K., Zástava, V., Kučerová, M., Bukva, V., Hamanová, J.: Fatal familial granulomatosis in children. Helv. paediat. Acta 25, 428 (1970).
Quie, P. G.: Chronic granulomatous disease of childhood. Advanc. Pediat. 16, 287 (1969).
Symchych, P. S., Wanstrup, J., Andersen, V.: Chronic granulomatous disease of childhood. A morphologic study. Acta path. microbiol. scand. 74, 179 (1968).
Thompson, E. N., Soothill, J. F.: Chronic granulomatous disease: Quantitative clinicopa-thological relationships. Arch. Dis. Childh. 45, 24 (1970).
Cortison-Lipidose
Breckenridge, R. T., Moore, R. D., Ratnoff, O. D.: A study of thrombocytopenia. New histologic criteria of the differentiation of idiopathic thrombocytopenia and the thrombocytopenia associated with disseminated lupus erythematosus. Blood 30, 39 (1967).
Dollberg, L., Casper, J., Djaldetti, M., Klibansky, Ch., De Vries, A.: Lipid-laden histiocytes in the spleen in thrombocytopenic purpura. Amer. J. clin. Path. 43, 16 (1965).
Hill, J. M., Speer, R. J., Gedikoglu, H.: Secondary lipidosis of spleen associated with thrombocytopenia and other blood dyspasias treated with cortisone. Amer. J. clin. Path. 39, 607 (1963).
Landing, B. H., Strauss, L., Crocker, A. C., Braunstein, H., Henley, W. L., Will, J. R., Sanders, M.: Thrombocytopenic purpura with histiocytosis of the spleen. New Engl. J. Med. 265, 572 (1961).
Speer, R. J., Ridgway, H., Hill, J. M.: Lipids of the human spleen. Amer. J. clin. Path. 38, 297 (1962).
Essentielle Hypercholesterinaemie und Lipaemie
Borrie, P.: Essential hyperlipemia and idiopathic hypercholesterolaemic xanthomatosis. Brit. med. J. 11, 911 (1957).
Ferrans, V. J., Buja, L. M., Roberts, W. C., Fredrickson, D. S.: The spleen in type I hyperlipoproteinemia. Amer. J. Path. 64, 67 (1971).
Goodman, M., Shuman, H., Goodman, S.: Idio-pathic lipemia with secondary xanthomatosis, hepatosplenomegaly, and lipemia retinate. J. Pediat. 16, 598 (1940).
Kinsell, L. W., Schlierf, G., Kahlke, W., Schettler, G.: Essential hyperlipemia. In Lipids and Lipidoses (Hrsg. G. Schettler), S. 446. Berlin-Heidelberg-New York: Springer 1967.
Schettler, G., Kahlke, W., Schlierf, G.: Essential hypercholesterolemia. In Lipids and Lipidoses (Hrsg. G. Schettler), S. 412. Berlin-Heidelberg-New York: Springer 1967.
Fabry’sche Glykolipidose
Brady, R. O., Gal, A. E., Bradley, R. M., Mårtensson, E.: The metabolism of ceramid trihexosides. J. biol. Chem. 242, 1021 (1967).
Brady, R. O., Gal, A. E., Bradley, R. M., Mårtensson, E., Warshaw, A.L., Laster, L.: Enzymatic defect in Fabry’s disease. New Engl. J. Med. 276, 1163 (1967).
Desnick, R. J., Sweeley, C. C., Krivit, W.: A method for the quantitative determination of neutral glycosphingolipids in urine sediment. J. Lipid Res. 11, 31 (1970).
Francois, J., Snacken, J., Stockmans, L.: Fabry’s disease (glycolipid lipidoses). Path. europ. 3, 347 (1968).
Kint, J. A.: Fabry’s disease: Alpha-galactosidase deficiency. Science 167, 1268 (1970).
Malmqvist, E., Ivemark B. I., Lindsten, K. J., Maunsbach, A., Mårtensson, E.: Histochemical, electronmicroscopical and biochemical studies on Fabry’s disease in a family with evidence of linkage with the sex-linked blood group Xg. Lab. Invest. 25, 1 (1971).
Philippart, M., Sarlieve, L., Mancorda, A.: Urinary glycolipids in Fabry’s disease. Their examination in the detection of atypical variants and the pre-symptomatic state. Pediatrics 43, 201 (1969).
Sweeley, C. C., Klionsky, B., Desnick, R. J., Krivit, W.: Fabry’s disease: Glycosphingolipid lipidosis. In The Metabolic Basis of Inherited Disease (Hrsg. Stanbury et al.), 3. Aufl. New York: MacGraw-Hill 1972.
Farbersche Lipogranulomatose
Crocker, A. C., Cohen, J., Farber, S.: The „lipogranulomatosis“syndrome; Review with report of patient showing milder involvement. In Inborn Disorders of Sphingolipid Metabolism (Hrsg. Aronson & Volk), S. 485. Oxford: Pergamon 1967.
Eleftheriou, D., Vlachos, J., Billis, A.: Fatal li-pogranulomatosis with atrial pseudotumour, intrahepatic sclerosing cholangitis and lymphoreticular proliferation simulating malignant lymphoma. Path. europ. 5, 348 (1970).
Molz, G.: Farbersche Krankheit. Pathologischanatomische Befunde. Virchows Arch. Abt. A 344, 86 (1968).
Moser, H. W., Prensky, A. L., Wolfe, H. J., Rosman, N. P.: Farber’s lipogranulomatosis. Report of a case and demonstration of an excess of free ceramide and ganglioside. Amer. J. Med. 47, 869 (1969).
Samuelsson, K., Zetterström, R.: Ceramides in a patient with lipogranulomatosis (Farber’s disease) with chronic course. Scand. J. clin. Lab. Invest. 27, 393 (1971).
Samuelsson, K., Zetterström, R., Ivemark, B. I.: Studies on a case of lipogranulomatosis (Farber’s disease) with protracted course. 4th International Symposium on Sphingoli-pids, Sphingolipidoses and Allied Disorders. New York: Plenum Press 1972.
Gangliosidose
O’Brien, J. S.: Generalized gangliosidoses. J. Pediat. 75, 167 (1969).
Schettler, G., Kahlke, W.: Neurovisceral gangliosidoses. In Lipids and Lipidoses (Hrsg. Schettler), S. 242. Berlin-Heidelberg-New York: Springer 1967.
Scott, C. R., Lagunoff, D., Trump, B. F.: Familial neurovisceral lipidosis. J. Pediat. 71, 357 (1967).
Suzuki, K.: Cerebral GM-1 gangliosidosis: Chemical pathology of visceral organs. Science 159, 1471 (1968).
Melanose und Mukoidophagen
Azzopardi, J. G., Evans, D. J.: Mucoprotein-containing histiocytes (muciphages) in the rectum. J. clin. Path. 19, 368 (1966).
Morbus Gaucher
Fredrickson, D. S.: Cerebroside lipidosis: Gaucher’s Disease. In The Metabolic Basis of Inherited Disease (Hrsg. Stanbury et al.), S. 730. New York: McGraw-Hill 1972.
Niemann-Picksche Krankheit
Fredrickson, D.: Sphingomyelin lipidosis: Niemann-Pick disease. In The Metabolic Basis of Inherited Disease (Hrsg. Stanbury et al.), S. 586. New York: McGraw-Hill 1966.
Ivemark, B. I., Svennerholm, L., Thorén, C., Tunell, R.: Niemann-Pick disease in infancy. Report of two siblings with clinical, histologic and chemical studies. Acta paediat. 52, 391 (1963).
Schettler, G., Kahlke, W.: Niemann-Pick disease. In Lipids and Lipidoses (Hrsg. Schettler), S. 288, Berlin-Heidelberg-New York: Springer 1967.
Schaumzellen bei Thalassaemie
Gordon, G. B., Hyun, B. H., Kuhn, M. L.: Pathogenesis of the foam cell in thalassemia. Lab. Med. Bull Path. 10, 398 (1969).
Schaumzellen in den Nieren
Zollinger, H. U., Rohr, H.-P.: Struktur und Bedeutung der renalen Schaumzellen. Vir-chows Arch. Abt. A 348, 205 (1969).
Sulfatidose
Kohn, R.: Papillomatosis of the gallbladder in metachromatic leukodystrophy. Amer. J. clin. Path. 52, 737 (1969). (Siehe auch Kap. 5.)
Tangiersche Krankheit
Bale, P. M., Clifton-Bligh, P., Benjamin, B. N. P., Whyte, H. M.: Pathology of Tangier disease. J. clin. Path. 24, 609 (1971).
Fredrickson, D.: Familial high-density lipoprotein deficiency: Tangier disease. In The Metabolic Basis of Inherited Disease (Hrsg. Stanbury, Wyngaarden & Fredrickson), S. 520, 3. Aufl. New York: McGraw-Hill 1972.
Kahlke, W.: Tangier disease. In Lipids and Lipidoses (Hrsg. Schettler), S. 401. Berlin-Heidelberg-New York: Springer 1967.
Whipplesche Krankheit
Aust, C. H., Smith, E. B.: Whipple’s disease in a 3-month-old infant with involvement of the bone marrow. Amer. J. clin. Path. 37, 66 (1962).
Maizel, H., Ruffin, J. M., Dobbins, W. O.: Whipple’s disease. A review of 19 patients from one hospital and a review of the literature since 1950. Medicine (Baltimore) 49, 175 (1970).
Phillips, M. J., Finlay, J. M.: Bacilli-lipid associations in Whipple’s disease. J. Path. Bact. 94, 131 (1967).
Roberts, D. M., Themann, H., Knust, F.-J., Preston, F. E., Donaldson, J. R.: An electron-microscope study of bacteria in two cases of Whipple’s disease. J. Path. 100, 249 (1970).
Rowlands, D. T., Landing, B. H.: Colonic histiocytosis in children. Report of a form resembling that seen in Whipple’s disease. Amer. J. Path. 36, 201 (1960).
Wolmansche Krankheit
Kahana, D., Berant, M., Wolman, M.: Primary familial xanthomatosis with adrenal involvement (Wolman’s disease). Report of a further case with nervous system involvement and pathogenetic considerations. Pediatrics 42, 70 (1968).
Lake, B. D., Patrick, A. S.: Wolman’s disease: Deficiency of E 600-resistant acid esterase activity with storage of lipids in lysosomes. J. Pediat. 76, 262 (1970).
Lough, J., Fawcett, J., Wiegensberg, B.: Wolman’s disease. An electron microscopic, histochemical, and biochemical study. Arch. Path. 89, 163 (1970).
Marshall, W. C., Ockenden, B. G., Fosbrocke, A. S., Cumings, J. N.: Wolman’s disease. A rare lipidosis with adrenal calcification. Arch. Dis. Childh. 44, 331 (1969).
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1974 Biörn Ivemark und Almqvist & Wiksell Förlag AB, Stockholm
About this chapter
Cite this chapter
Ivemark, B. (1974). Schaumzellanalyse. In: Kinderpathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65723-8_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-65723-8_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-65724-5
Online ISBN: 978-3-642-65723-8
eBook Packages: Springer Book Archive