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Studies of Flux Rates at the Glucose 6-Phosphate Crossover

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Central Nervous System

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Abstract

The special case of the metabolism of the rat brain after application of 6-aminonicotinamide (6-AN) was described in the preceding chapter by Herken. The main facts are: 6-AN leads to the formation of 6-aminonicotinamide adenine dinucleotide phosphate (6-ANADP) which, by inhibiting 6-phosphogluconate deydrogenase results in a large accumulation, up to about 2 mM, of 6-phosphogluconate. This is sufficient to inhibit the glucose phosphate isomerase severely, and it may influence the glycolytic rate in the brain.

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Author information

Authors and Affiliations

  1. Pharmakologisches Institut, Freien Universität Berlin, Western Germany

    K. Lange, K. Keller & H. Kolbe

Authors
  1. K. Lange
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  2. K. Keller
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  3. H. Kolbe
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Turin, Corso Raffaello, 30, I-10125, Turin, Italy

    E. Genazzani

  2. Pharmakologisches Institut, Freien Universität Berlin, D-1000, Berlin 33, Thielallee 69/73, Germany

    H. Herken

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© 1974 Springer-Verlag Berlin · Heidelberg

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Lange, K., Keller, K., Kolbe, H. (1974). Studies of Flux Rates at the Glucose 6-Phosphate Crossover. In: Genazzani, E., Herken, H. (eds) Central Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65714-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-65714-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65716-0

  • Online ISBN: 978-3-642-65714-6

  • eBook Packages: Springer Book Archive

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